Anger as feeling, as expression and as harm to others.
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Qurʾān
القرآن6 shownVerses named for this subject by hand come first. The rest are found by the subject’s own Arabic and English senses and are shown as lexical matches, not as anchors anyone has confirmed.
Qur'ān 3:134Arabic sense: الغيظ, غيظ | English sense: anger, restrain | named: named for theme_bridge theme anger-restraint
ٱلَّذِينَ يُنفِقُونَ فِي ٱلسَّرَّآءِ وَٱلضَّرَّآءِ وَٱلۡكَٰظِمِينَ ٱلۡغَيۡظَ وَٱلۡعَافِينَ عَنِ ٱلنَّاسِۗ وَٱللَّهُ يُحِبُّ ٱلۡمُحۡسِنِينَ
who give, both in prosperity and adversity, who restrain their anger and pardon people- God loves those who do good
Qur'ān 42:37English sense: angry | Arabic sense: غضب | named: named for theme_bridge theme anger-restraint
وَٱلَّذِينَ يَجۡتَنِبُونَ كَبَٰٓئِرَ ٱلۡإِثۡمِ وَٱلۡفَوَٰحِشَ وَإِذَا مَا غَضِبُواْ هُمۡ يَغۡفِرُونَ
who shun great sins and gross indecencies; who forgive when they are angry
Qur'ān 7:154Arabic sense: الغضب, غضب | English sense: anger
وَلَمَّا سَكَتَ عَن مُّوسَى ٱلۡغَضَبُ أَخَذَ ٱلۡأَلۡوَاحَۖ وَفِي نُسۡخَتِهَا هُدࣰ ى وَرَحۡمَةࣱ لِّلَّذِينَ هُمۡ لِرَبِّهِمۡ يَرۡهَبُونَ
When Moses’ anger abated, he picked up the Tablets, on which were inscribed guidance and mercy for those who stood in awe of their Lord
Qur'ān 20:86Arabic sense: غضب | English sense: anger, angry
فَرَجَعَ مُوسَىٰٓ إِلَىٰ قَوۡمِهِۦ غَضۡبَٰنَ أَسِفࣰ اۚ قَالَ يَٰقَوۡمِ أَلَمۡ يَعِدۡكُمۡ رَبُّكُمۡ وَعۡدًا حَسَنًاۚ أَفَطَالَ عَلَيۡكُمُ ٱلۡعَهۡدُ أَمۡ أَرَدتُّمۡ أَن يَحِلَّ عَلَيۡكُمۡ غَضَبࣱ مِّن رَّبِّكُمۡ فَأَخۡلَفۡتُم مَّوۡعِدِي
Moses returned to his people, angry and aggrieved. He said, ‘My people, did your Lord not make you a gracious promise? Was my absence too long for you? Did you want anger to fall on you from your Lord and so broke your word to me?’
Qur'ān 3:119Arabic sense: الغيظ, غيظ
هَٰٓأَنتُمۡ أُوْلَآءِ تُحِبُّونَهُمۡ وَلَا يُحِبُّونَكُمۡ وَتُؤۡمِنُونَ بِٱلۡكِتَٰبِ كُلِّهِۦ وَإِذَا لَقُوكُمۡ قَالُوٓاْ ءَامَنَّا وَإِذَا خَلَوۡاْ عَضُّواْ عَلَيۡكُمُ ٱلۡأَنَامِلَ مِنَ ٱلۡغَيۡظِۚ قُلۡ مُوتُواْ بِغَيۡظِكُمۡۗ إِنَّ ٱللَّهَ عَلِيمُۢ بِذَاتِ ٱلصُّدُورِ
This is how it is: here you are, you love them, but they do not love you; you believe in all the Scriptures and when they meet you, they say, ‘We believe,’ but when they are alone, they bite their fingertips in rage at you. [Prophet], say, ‘Die of rage [if you wish]!’ God knows exactly what is in everyone’s hearts
Qur'ān 7:71Arabic sense: غضب | English sense: anger
قَالَ قَدۡ وَقَعَ عَلَيۡكُم مِّن رَّبِّكُمۡ رِجۡسࣱ وَغَضَبٌۖ أَتُجَٰدِلُونَنِي فِيٓ أَسۡمَآءࣲ سَمَّيۡتُمُوهَآ أَنتُمۡ وَءَابَآؤُكُم مَّا نَزَّلَ ٱللَّهُ بِهَا مِن سُلۡطَٰنࣲۚ فَٱنتَظِرُوٓاْ إِنِّي مَعَكُم مِّنَ ٱلۡمُنتَظِرِينَ
He said, ‘You are already set to receive your Lord’s loathing and anger. Are you arguing with me about mere names you and your forefathers invented, names for which God has given no sanction? Just wait; I too am waiting.’
Research library, full list
151 to 175 of 770Exogenous testosterone enhances responsiveness to social threat in the neural circuitry of social aggression in humans.
Background: In a range of species, the androgen steroid testosterone is known to potentiate neural circuits involved in intraspecific aggression. Disorders of impulsive aggression in humans have likewise been associated with high testosterone levels, but human evidence for the link between testosterone and aggression remains correlational and inconclusive.
Methods: Twelve female participants underwent functional magnetic resonance imaging during three sessions while viewing stimuli differing in social threat value: angry and happy facial expressions. The first session served to establish associations between baseline hormone levels and neural activation. Participants were retested in a second and third session after placebo-controlled sublingual administration of .5 mg testosterone.
Results: Findings demonstrate consistent activation to angry versus happy faces in areas known to be invol…
matched on Aggression (mesh)
Behavioral and mood effects of snoezelen integrated into 24-hour dementia care.
Objectives: To investigate the effectiveness of snoezelen, integrated in 24-hour daily care, on the behavior and mood of demented nursing home residents.
Design: Quasiexperimental pre- and posttest design.
Setting: Twelve psychogeriatric wards of six nursing homes, spread over different parts of the Netherlands.
Participants: One hundred twenty-five patients with moderate to severe dementia and care dependency were included in the pretest and 128 in the posttest; 61 were completers (included in both pre- and posttest).
Intervention: Experimental subjects received an individual 24-hour snoezel program, based on family history taking and stimulus preference screening. Caregivers were trained, and (organizational) adaptations were made to fulfill the conditions for resident-oriented snoezel care. The control group received usual nursing home care.
Measurements: Observations were made on the…
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Anger Rumination as a Moderator of the Association between Factor 2 of Psychopathy and Proactive Aggression.
Objective: Scholars have identified psychopathic traits as facilitators of intimate partner violence (IPV). Analyzing anger management strategies might clarify how these personality traits contribute to violence proneness. One potential moderator to consider is the tendency to ruminate about anger (or anger rumination). However, the pattern of association between psychopathic traits and violence proneness differs depending on psychopathy factors and the subtypes of violence expression (reactive or proactive). Therefore, the main objective of this study was to examine whether the two factors of psychopathy and/or the total score would explain the expression of violence subtype (reactive and proactive), introducing anger rumination as a moderator and controlling the effect of potential confounding factors. Method: A total of 125 healthy men (64 IPV perpetrators and 61 controls) were recrui…
matched on Anger (mesh), Aggression (mesh), Rumination, Cognitive (mesh), anger management (text), anger rumination (text)
Impact of dialectical behavior therapy versus community treatment by experts on emotional experience, expression, and acceptance in borderline personality disorder.
Evidence suggests that heightened negative affectivity is a prominent feature of Borderline Personality Disorder (BPD) that often leads to maladaptive behaviors. Nevertheless, there is little research examining treatment effects on the experience and expression of specific negative emotions. Dialectical Behavior Therapy (DBT) is an effective treatment for BPD, hypothesized to reduce negative affectivity (Linehan, 1993a). The present study analyzes secondary data from a randomized controlled trial with the aim to assess the unique effectiveness of DBT when compared to Community Treatment by Experts (CTBE) in changing the experience, expression, and acceptance of negative emotions. Suicidal and/or self-injuring women with BPD (n = 101) were randomly assigned to DBT or CTBE for one year of treatment and one year of follow-up. Several indices of emotional experience and expression were asses…
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Pornography and teenagers: the importance of individual differences.
This article focuses on the effects of exposure to pornography on teenagers, particularly males, and concentrates on sexually aggressive outcomes and on the characteristics of the individual as crucial in determining whether pornography consumption may or may not lead to sexually aggressive outcomes. In future work, it is important not to use an overly simplistic lens of focus in which pornography exposure is seen as generally harmful or not. Depending on particular constellations of personality characteristics, the effects of pornography may differ considerably among different teenagers as well as within different cultures. The research suggests that particular concerns may be needed for those who are highly frequent consumers of pornography, those who seek out sexually violent content, and those who also have other risk factors.
matched on Aggression (mesh), Hostility (mesh)
Measures of morally injurious experiences: A quantitative comparison.
A recent body of literature has examined the psychological effects of perpetrating or failing to prevent acts that violate one's sense of right and wrong. The objective of this study was to examine and compare correlations between the two most widely used instruments measuring this construct in a sample of military veterans and relevant psychosocial variables. Individuals (N = 182) who reported military combat experience completed the Moral Injury Events Scale and the Moral Injury Questionnaire-Military Version, along with measures of combat exposure, depression, posttraumatic stress disorder, alcohol concerns, anger, guilt, and shame. Results indicate similar correlations between the morally injurious experiences instruments and negative psychosocial variables, but different correlations with combat exposure. Implications for further research in the conceptualization and treatment of mo…
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Di Giunta L, Iselin AR, Eisenberg N, Pastorelli C, Gerbino M, Lansford JE, Dodge KA, Caprara GV, Bacchini D, Uribe Tirado LM, Thartori E (2017)cohort or longitudinalMEDLINE-indexed journal, not yet read by usAssessment15 citations Measurement Invariance and Convergent Validity of Anger and Sadness Self-Regulation Among Youth From Six Cultural Groups.
The present study examined measurement invariance and convergent validity of a novel vignette-based measure of emotion-specific self-regulation that simultaneously assesses attributional bias, emotion-regulation, and self-efficacy beliefs about emotion regulation. Participants included 541 youth-mother dyads from three countries (Italy, the United States, and Colombia) and six ethnic/cultural groups. Participants were 12.62 years old ( SD = 0.69). In response to vignettes involving ambiguous peer interactions, children reported their hostile/depressive attribution bias, self-efficacy beliefs about anger and sadness regulation, and anger/sadness regulation strategies (i.e., dysregulated expression and rumination). Across the six cultural groups, anger and sadness self-regulation subscales had full metric and partial scalar invariance for a one-factor model, with some exceptions. We found …
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Negative emotions towards others are diminished in remitted major depression.
Background: One influential view is that vulnerability to major depressive disorder (MDD) is associated with a proneness to experience negative emotions in general. In contrast, blame attribution theories emphasise the importance of blaming oneself rather than others for negative events. Our previous exploratory study provided support for the attributional hypothesis that patients with remitted MDD show no overall bias towards negative emotions, but a selective bias towards emotions entailing self-blame relative to emotions that entail blaming others. More specifically, we found a decreased proneness for contempt/disgust towards others relative to oneself (i.e. self-contempt bias). Here, we report a definitive test of the competing general negative versus specific attributional bias theories of MDD.
Methods: We compared a medication-free remitted MDD (n=101) and a control group (n=70) wi…
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Impact of sleep quality on amygdala reactivity, negative affect, and perceived stress.
Objective: Research demonstrates a negative impact of sleep disturbance on mood and affect; however, the biological mechanisms mediating these links are poorly understood. Amygdala reactivity to negative stimuli has emerged as one potential pathway. Here, we investigate the influence of self-reported sleep quality on associations between threat-related amygdala reactivity and measures of negative affect and perceived stress.
Methods: Analyses on data from 299 participants (125 men, 50.5% white, mean [standard deviation] age = 19.6 [1.3] years) who completed the Duke Neurogenetics Study were conducted. Participants completed several self-report measures of negative affect and perceived stress. Threat-related (i.e., angry and fearful facial expressions) amygdala reactivity was assayed using blood oxygen level-dependent functional magnetic resonance imaging. Global sleep quality was assesse…
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The erosive effects of racism: reduced self-control mediates the relation between perceived racial discrimination and substance use in African American adolescents.
Perceived racial discrimination, self-control, anger, and either substance use or use cognitions were assessed in 2 studies conducted with samples of African American adolescents. The primary goal was to examine the relation between discrimination and self-control over time; a 2nd goal was to determine whether that relation mediates the link between discrimination and substance use found in previous research. Study 1, which included a latent growth curve analysis with 3 waves of data, indicated that experience with discrimination (from age 10 years to age 18 years) was associated with reduced self-control, which then predicted increased substance use. Additional analyses indicated anger was also a mediator of this discrimination to use relation. Study 2, which was experimental, showed that envisioning an experience involving discrimination was associated with an increase in substance-rel…
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The expression and regulation of anger in toddlers: relations to maternal behavior and mental representations.
Anger is an intense and adaptive approach emotion that undergoes significant development during the toddler years. We assessed the expression of anger and the strategies toddlers use to regulate it in relation to maternal behavior and mental representations. Seventy-four toddlers were observed in three anger-eliciting paradigms: toy removal (TR), still-face (SF), and delayed gratification (DG). Anger expression and three clusters of regulatory behaviors were micro-coded: putative regulatory behaviors, attention manipulation, and play behaviors. Maternal relational style was coded for sensitivity and intrusiveness, and mental representations of the mother-child relationship were assessed for joy and anger. Children expressed the most anger during the TR, less during the SF, and minimally during the DG. Use of putative regulatory behaviors was highest during the SF, whereas during the TR c…
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Two different faces of threat. Comparing the neural systems for recognizing fear and anger in dynamic body expressions.
Being exposed to fear or anger signals makes us feel threatened and prompts us to prepare an adaptive response. Yet, while fear and anger behaviors are both threat signals, what counts as an adaptive response is often quite different. In contrast with fear, anger is often displayed with the aim of altering the behavior of the agent to which it is addressed. To identify brain responses that are common or specific to the perception of these two types of threat signals, we used functional magnetic resonance imaging and asked subjects to recognize dynamic actions expressing fear, anger and neutral behaviors. As compared with neutral actions, the perception of fear and anger behaviors elicited comparable activity increases in the left amygdala and temporal cortices as well as in the ventrolateral and the dorsomedial prefrontal cortex. Whereas the perception of fear elicited specific activity …
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Sex differences in emotional and physiological responses to the Trier Social Stress Test.
Women are more likely than men to be diagnosed with depression and anxiety-related disorders, and it has been hypothesized that this difference is related to sex differences in stress reactivity. Women typically report higher levels of negative affect than men in response to psychosocial stressors, but the evidence for sex differences in physiological reactivity to stressful situations is not consistent. The present study sought to expand this work by evaluating sex differences in reactivity to a social stress challenge across neuroendocrine, autonomic and affective response domains. Participants (32 women, 30 men) completed a standardized psychosocial stress challenge (i.e., the Trier Social Stress Test (TSST)), during which several physiological (e.g., cortisol reactivity, heart rate) and psychological (e.g., depression, irritability, anger, fear) measures were assessed. The findings d…
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Increased amygdala and insula activation during emotion processing in anxiety-prone subjects.
Objective: Increased amygdala reactivity during processing of certain types of emotional stimuli (e.g., fear, anger) has been observed in patients with anxiety disorders such as social phobia and posttraumatic stress disorder (PTSD). It is uncertain whether this heightened amygdala reactivity is specific to treatment-seeking patients with anxiety disorders or is a general feature of individuals with increased anxiety-related temperamental traits.
Method: Thirty-two physically healthy subjects 18-21 years old were recruited from a large pool of college students. Of these, 16 were chosen on the basis of scoring in the upper-15th percentile on a measure of trait anxiety (anxiety-prone group), and 16 were chosen on the basis of scoring in the normative range (40th-60th percentile). Subjects participated in functional magnetic resonance imaging (fMRI) during an emotion face assessment task th…
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Positive emotional change: mediating effects of forgiveness and spirituality.
We evaluated the efficacy of an emotional education program that seeks to reduce the intergenerational transmission of negative interaction patterns by increasing forgiveness and spirituality. We examined both reduction of psychological symptoms and increase in positive psychological outcomes over the course of a year, as well as the mediators of this change. At baseline, the sample consisted of 99 participants and 47 waiting list controls. Comparisons of scores from baseline (Time 1) to one week after the Hoffman Quadrinity Process (Time 2) showed large declines in negative affect (depressive symptoms) and increases in both positive outcomes (mastery, empathy, emotional intelligence, life satisfaction, forgiveness, and spiritual experience) and health and well-being. Over the course of a year, most of these gains were sustained, in comparison with the control group. Further, increases i…
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Self-reported discrimination and mental health status among African descendants, Mexican Americans, and other Latinos in the New Hampshire REACH 2010 Initiative: the added dimension of immigration.
Objectives: We examined whether self-reported racial discrimination was associated with mental health status and whether this association varied with race/ethnicity or immigration status.
Methods: We performed secondary analysis of a community intervention conducted in 2002 and 2003 for the New Hampshire Racial and Ethnic Approaches to Community Health 2010 Initiative, surveying African descendants, Mexican Americans, and other Latinos. We assessed mental health status with the Mental Component Summary (MCS12) of the Medical Outcomes Study Short Form 12, and measured discrimination with questions related to respondents' ability to achieve goals, discomfort/anger at treatment by others, and access to quality health care.
Results: Self-reported discrimination was associated with a lower MCS12 score. Additionally, the strength of the association between self-reported health care discriminat…
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Emotions during sexual activity: differences between sexually functional and dysfunctional men and women.
The present study investigated the differences in emotional response to automatic thoughts presented during sexual activity between sexually functional and dysfunctional men and women. A total of 376 participants (160 women and 120 men without sexual problems and 47 women and 49 men with a DSM-IV-TR diagnosis of sexual dysfunction) completed the Sexual Modes Questionnaire (SMQ male and female versions; P. J. Nobre & J. Pinto-Gouveia, 2000) and measures of sexual functioning: The International Index of Sexual Function (IIEF; R. C. Rosen et al., 1997), and The Female Sexual Function Index (FSFI; R. C. Rosen et al., 2000). The SMQ is a combined measure constituted by three interdependent subscales: Automatic Thought subscale (AT), Emotional Response subscale (ER), and Sexual Response subscale (SR). Emotions were assessed by the ER subscale, where participants endorsed emotional reactions (w…
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Role of Irrational Beliefs and Anger Rumination on Nurses' Anger Expression Styles.
The aim of this study was to identify whether certain cognitive factors, such as irrational beliefs and anger rumination, affect nurses' anger expression styles. A total of 335 nurses employed at four tertiary hospitals in Korea completed surveys between July 29 and September 25, 2015. The surveys included Shortened General Attitude and Belief Scale, the Korean Version of the Anger Rumination Scale, and the State-Trait Anger Expression Inventory-Korean version. Results revealed that higher levels of irrational beliefs and anger rumination were associated with more anger-in and anger-out, and less anger-control expressions. Findings indicate that the presence of specific cognitive characteristics could lead to maladaptive anger expressions. Active consideration of these cognitive risk factors is essential when developing anger-management programs for nurses.
matched on Anger (mesh), Hostility (keyword), Rumination, Cognitive (mesh), anger management (text), anger rumination (text), trait anger (text)
Krizan Z, Johar O (2015)MEDLINE-indexed journal, not yet read by usJournal of personality and social psychology56 citations Narcissistic rage revisited.
Narcissists are thought to exhibit "narcissistic rage," an explosive mix of anger and hostility arising from threats to narcissists' fractured sense of self. Building on clinical views of narcissism, we present empirical evidence on the nature and sources of narcissistic rage. Findings from 4 studies reveal narcissistic vulnerability (but not grandiosity) as a powerful driver of rage, hostility, and aggressive behavior, fueled by suspiciousness, dejection, and angry rumination. Consistent with theorizing about narcissistic rage, Study 1 showed that vulnerable (but not grandiose) narcissism predicted more anger internalization and externalization, as well as poorer anger control. Study 2 revealed vulnerable narcissism as a stronger indicator of shame and aggressiveness, especially hostility and anger. Study 3 identified distrust of others and angry rumination as key factors accounting for…
matched on Anger (mesh), Aggression (mesh), Hostility (mesh)
Rumination partially mediates the associations between perceived ethnic discrimination, emotional distress, and aggression.
Research suggests that perceived ethnic discrimination is associated with poor psychological and physiological health. Rumination, or perseverative thoughts about negative experiences, may constitute a maladaptive coping strategy that mediates the associations between perceived discrimination, emotional distress, and aggression. Our sample consisted of 170 ethnic minority and 134 White American participants. For ethnic minority participants, we found a pattern of correlations consistent with rumination partially mediating a causal link between perceived discrimination and depressive symptoms, hostility, anger, and aggression. In White participants, by contrast, the significant associations between perceived discrimination and these indices of emotional and behavioral distress were not statistically mediated by rumination. We discuss possible theoretical and clinical implications of these…
matched on Anger (mesh), Aggression (mesh), Hostility (mesh)
Trait and state hostile rumination facilitate alcohol-related aggression.
Objective: This investigation attempted to determine whether trait and state hostile rumination functioned as risk factors for the relation between acute alcohol intoxication and aggression.
Method: Participants were 516 social drinkers (252 men and 264 women). Trait hostile rumination was assessed using Caprara's Dissipation-Rumination Scale. Following the consumption of either an alcohol or a placebo beverage, participants were tested on a laboratory task in which electric shocks were received from and administered to a fictitious opponent under the guise of a competitive reaction-time task. Aggression was operationalized as the combined mean responses for shock intensity and duration across all trials. In a subset of the sample (n = 320), state hostile rumination was assessed following the aggression task using a self-report measure.
Results: As expected, both trait and state measures…
matched on Anger (mesh), Aggression (mesh), Hostility (mesh)
Could mindfulness decrease anger, hostility, and aggression by decreasing rumination?
Research suggests that rumination increases anger and aggression. Mindfulness, or present-focused and intentional awareness, may counteract rumination. Using structural equation modeling, we examined the relations between mindfulness, rumination, and aggression. In a pair of studies, we found a pattern of correlations consistent with rumination partially mediating a causal link between mindfulness and hostility, anger, and verbal aggression. The pattern was not consistent with rumination mediating the association between mindfulness and physical aggression. Although it is impossible with the current nonexperimental data to test causal mediation, these correlations support the idea that mindfulness could reduce rumination, which in turn could reduce aggression. These results suggest that longitudinal work and experimental manipulations mindfulness would be worthwhile approaches for furthe…
matched on Anger (mesh), Aggression (mesh), Hostility (mesh)
Cognitive and emotional differences between abusive and non-abusive fathers.
Objective: Abusive fathers perpetrate a substantial portion of child physical abuse. Despite this, little is known about how they differ from non-abusive fathers. This study compared a broad range of cognitive and affective factors between physically abusive and non-abusive fathers.
Methods: Abusive (n=24) and non-abusive (n=25) fathers completed standard measures assessing their experience and expression of anger, mental health, parenting stress, and their empathy and perceptions of children's socio-emotional signals.
Results: Abusive fathers differed from comparisons on almost all constructs. They experienced more anger and were more likely to express that anger aggressively. They reported more mental health concerns (such as depression, hostility, and paranoid ideation), more stress in parenting, and significantly less empathy for their children. They were also more likely to perceive…
matched on Anger (mesh), Aggression (mesh), Hostility (mesh)
Understanding clinical anger and violence: the anger avoidance model.
Although anger is a primary emotion and holds clear functional necessities, the presence of anger and its behavioral manifestations of aggression/violence can have serious emotional, health, and social consequences. Despite such consequences, the construct of clinical anger has to date suffered from few theoretical and treatment advancements and has received insufficient research attention. Thus, the purpose of this article is to introduce the Anger Avoidance Model, which is a new conceptualization of clinical anger and its behavioral manifestations. The Anger Avoidance Model suggests that among anger patients, a chronic early aversive history leads to information processing biases and emotion regulation deficits, which in turn result in intense efforts to avoid the experience of anger. This avoidance takes the form of hostile rumination (cognitive avoidance) and aggressive and violent b…
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Leibenluft E (2017)reviewMEDLINE-indexed journal, not yet read by usTrends in cognitive sciences134 citations Pediatric Irritability: A Systems Neuroscience Approach.
Irritability, defined as an increased propensity to exhibit increased anger relative to one's peers, is a common clinical problem in youth. Irritability can be conceptualized as aberrant responses to frustration (where frustration is the emotional response to blocked goal attainment) and/or aberrant 'approach' responses to threat. Irritable youth show hyper-reactivity to threat mediated by dysfunction in amygdala, medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), insula, striatum, and association cortex. Irritable youth also show abnormalities in reward learning, cognitive control, and responses to frustration. These abnormalities are mediated by circuitry that includes the inferior frontal gyrus (iFG), striatum, ACC, and parietal cortex. Effective treatments for irritability are lacking, but pathophysiological research could lead to more precisely targeted interventions.
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