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Anxiety and worry القلق

Anticipatory fear, worry and generalised anxiety.

Everything below was reached through this subject, not through the words you typed. Every row states how it was reached.

Qurʾān

القرآن6 shown

Verses named for this subject by hand come first. The rest are found by the subject’s own Arabic and English senses and are shown as lexical matches, not as anchors anyone has confirmed.

Qur'ān 16:112English sense: fear | Arabic sense: الخوف, خوف

وَضَرَبَ ٱللَّهُ مَثَلࣰ ا قَرۡيَةࣰ كَانَتۡ ءَامِنَةࣰ مُّطۡمَئِنَّةࣰ يَأۡتِيهَا رِزۡقُهَا رَغَدࣰ ا مِّن كُلِّ مَكَانࣲ فَكَفَرَتۡ بِأَنۡعُمِ ٱللَّهِ فَأَذَٰقَهَا ٱللَّهُ لِبَاسَ ٱلۡجُوعِ وَٱلۡخَوۡفِ بِمَا كَانُواْ يَصۡنَعُونَ

God presents the example of a town that was secure and at ease, with provisions coming to it abundantly from all places. Then it became ungrateful for God’s blessings, so God afflicted it with the garment of famine and fear, for what its people had done

Qur'ān 2:155English sense: fear | Arabic sense: الخوف, خوف

وَلَنَبۡلُوَنَّكُم بِشَيۡءࣲ مِّنَ ٱلۡخَوۡفِ وَٱلۡجُوعِ وَنَقۡصࣲ مِّنَ ٱلۡأَمۡوَٰلِ وَٱلۡأَنفُسِ وَٱلثَّمَرَٰتِۗ وَبَشِّرِ ٱلصَّٰبِرِينَ

We shall certainly test you with fear and hunger, and loss of property, lives, and crops. But [Prophet], give good news to those who are steadfast

Qur'ān 21:103English sense: fear | Arabic sense: الفزع, فزع

لَا يَحۡزُنُهُمُ ٱلۡفَزَعُ ٱلۡأَكۡبَرُ وَتَتَلَقَّىٰهُمُ ٱلۡمَلَٰٓئِكَةُ هَٰذَا يَوۡمُكُمُ ٱلَّذِي كُنتُمۡ تُوعَدُونَ

They will have no fear of the great Terror: the angels will receive them with the words, ‘This is the Day you were promised!’

Qur'ān 33:19English sense: fear | Arabic sense: الخوف, خوف

أَشِحَّةً عَلَيۡكُمۡۖ فَإِذَا جَآءَ ٱلۡخَوۡفُ رَأَيۡتَهُمۡ يَنظُرُونَ إِلَيۡكَ تَدُورُ أَعۡيُنُهُمۡ كَٱلَّذِي يُغۡشَىٰ عَلَيۡهِ مِنَ ٱلۡمَوۡتِۖ فَإِذَا ذَهَبَ ٱلۡخَوۡفُ سَلَقُوكُم بِأَلۡسِنَةٍ حِدَادٍ أَشِحَّةً عَلَى ٱلۡخَيۡرِۚ أُوْلَٰٓئِكَ لَمۡ يُؤۡمِنُواْ فَأَحۡبَطَ ٱللَّهُ أَعۡمَٰلَهُمۡۚ وَكَانَ ذَٰلِكَ عَلَى ٱللَّهِ يَسِيرࣰ ا

who begrudge you [believers] any help. When fear comes, you [Prophet] see them looking at you with eyes rolling like someone in their death throes; when fear has passed, they attack you with sharp tongues and begrudge you any good. Such men do not believe, and God brings their deeds to nothing- that is all too easy for God

Qur'ān 4:83Arabic sense: الخوف, خوف

وَإِذَا جَآءَهُمۡ أَمۡرࣱ مِّنَ ٱلۡأَمۡنِ أَوِ ٱلۡخَوۡفِ أَذَاعُواْ بِهِۦۖ وَلَوۡ رَدُّوهُ إِلَى ٱلرَّسُولِ وَإِلَىٰٓ أُوْلِي ٱلۡأَمۡرِ مِنۡهُمۡ لَعَلِمَهُ ٱلَّذِينَ يَسۡتَنۢبِطُونَهُۥ مِنۡهُمۡۗ وَلَوۡلَا فَضۡلُ ٱللَّهِ عَلَيۡكُمۡ وَرَحۡمَتُهُۥ لَٱتَّبَعۡتُمُ ٱلشَّيۡطَٰنَ إِلَّا قَلِيلࣰ ا

Whenever news of any matter comes to them, whether concerning peace or war, they spread it about; if they referred it to the Messenger and those in authority among them, those seeking its meaning would have found it out from them. If it were not for God’s bounty and mercy towards you, you would almost all have followed Satan

Qur'ān 41:30English sense: fear | Arabic sense: تحزنوا

إِنَّ ٱلَّذِينَ قَالُواْ رَبُّنَا ٱللَّهُ ثُمَّ ٱسۡتَقَٰمُواْ تَتَنَزَّلُ عَلَيۡهِمُ ٱلۡمَلَٰٓئِكَةُ أَلَّا تَخَافُواْ وَلَا تَحۡزَنُواْ وَأَبۡشِرُواْ بِٱلۡجَنَّةِ ٱلَّتِي كُنتُمۡ تُوعَدُونَ

As for those who say, ‘Our Lord is God,’ and take the straight path towards Him, the angels come down to them and say, ‘Have no fear or grief, but rejoice in the good news of Paradise, which you have been promised

Tafsīr

التفسير6 shown

Commentary on the verses above, at most two editions per verse.

en-asbab-al-nuzul-by-al-wahidi on 2:155en-asbab-al-nuzul-by-al-wahidicommentary on an ayah this subject surfaced

And We will indeed try you with something of fear and hunger, and decrease of wealth, souls, and fruits; and give good news to the patient. The custom of the Lord is that whenever He threatens the servant and shows harshness in a verse, then, right after that or before it, He caresses the servant and gives him hope. Thus in this verse He breaks the servant by mentioning those harsh things and varieties of trial. Then He gives good news, He caresses, and He says, “and give good news to the patient.” And, at the beginning of these verses He says, “Surely God is with the patient” [2:153]. Glory be to Him! How gentle and how merciful He is to His servants! And We will indeed try you. He says, “We will test you, sometimes with fear, sometimes with dread, sometimes with poverty, sometimes with hunger, sometimes with outward affliction, sometimes with inward sorrow.” The outward trial and evide

en-asbab-al-nuzul-by-al-wahidi on 21:103en-asbab-al-nuzul-by-al-wahidicommentary on an ayah this subject surfaced

The greatest terror shall not make them sorrow, and the angels will receive them: “This is the day that you were promised.” On the Day of Resurrection in the greatest gathering place and most tremendous courtyard, they will not hear from the angels the call “no good news” [25:22], nor the address, “Stand apart today, O offenders!” [36:59], nor the harsh call, “Slink into it, and do not talk to Me!” [23:108]. They will not hear the call of separation's pain, nor will they despair of mercy. Rather the angels will keep on coming, company after company, and they will give the good news: “This is the day that you were promised,” that is, “This is the day in which you have the promised reward.” Among them are those who will be received by the angels, and among them are those who will be addressed and made known by the King. God will say, “My servants, have you been yearning for Me?” He will sa

en-al-jalalayn on 16:112en-al-jalalayncommentary on an ayah this subject surfaced

And God strikes a similitude mathalan is substituted by the following qaryatan a town Mecca — meaning its inhabitants — secure from any raids never becoming agitated and peaceful without anyone ever needing to emigrate from it on account of anxiety or fear its provision coming to it plenteously abundantly from every place. But it rejected God’s graces by denying the Prophet s so God made it taste the garb of hunger and so they suffered seven years of drought and fear as a result of the raiding parties of the Prophet s all because of what they used to do.

en-al-jalalayn on 2:155en-al-jalalayncommentary on an ayah this subject surfaced

Surely We will try you with something of fear of an enemy and hunger by way of drought and diminution of goods as a result of destruction and lives as a result of slaughter death and disease and fruits by way of crop damage that is to say We will try you to see if you practise patience or not; yet give good tidings of Paradise to the patient during calamities;

en-al-jalalayn on 21:103en-al-jalalayncommentary on an ayah this subject surfaced

The Supreme Terror — which is that a servant be ordered off to the Fire shall not grieve them and the angels shall receive them upon their exiting from their graves saying to them ‘This is your day the one which you were promised’ during the life of the world.

en-tafisr-ibn-kathir on 16:112en-tafisr-ibn-kathircommentary on an ayah this subject surfaced

And Allah gives the example of a township (Makkah), it was secure and peaceful: its provision coming to it in abundance from every place, but it (its people) denied the favors of Allah. So Allah made it taste extreme hunger (famine) and fear, because of what they did (112)There has come to them a Messenger from among themselves, but they denied him, so the torment seized them while they were wrongdoers (113) The Example of Makkah This example refers to the people of Makkah, which had been secure, peaceful and stable, a secure sanctuary while men were being snatched away from everywhere outside of it. Whoever entered Makkah, he was safe, and he had no need to fear, as Allah said: وَقَالُوا إِن نَّتَّبِعِ الْهُدَىٰ مَعَكَ نُتَخَطَّفْ مِنْ أَرْضِنَا ۚ أَوَلَمْ نُمَكِّن لَّهُمْ حَرَمًا آمِنًا يُجْبَىٰ إِلَيْهِ ثَمَرَاتُ كُلِّ شَيْءٍ رِّزْقًا مِّن لَّدُنَّا (And they say: "If we follow th

Ḥadīth

الحديث4 shown

Sound narrations only, and never matched by text. A narration appears here because a compiler filed it under a chapter this subject maps to, or because someone read it and anchored it. Each row says which.

Sunan an-Nasa'i 5428Seeking Refuge With Allahfiled here by the compiler

أَخْبَرَنَا أَبُو عَبْدِ الرَّحْمَنِ، أَحْمَدُ بْنُ شُعَيْبٍ قَالَ أَنْبَأَنَا عَمْرُو بْنُ عَلِيٍّ، قَالَ حَدَّثَنَا أَبُو عَاصِمٍ، قَالَ حَدَّثَنَا ابْنُ أَبِي ذِئْبٍ، قَالَ حَدَّثَنِي أَسِيدُ بْنُ أَبِي أَسِيدٍ، عَنْ مُعَاذِ بْنِ عَبْدِ اللَّهِ، عَنْ أَبِيهِ، قَالَ أَصَابَنَا طَشٌّ وَظُلْمَةٌ فَانْتَظَرْنَا رَسُولَ اللَّهِ صلى الله عليه وسلم لِيُصَلِّيَ بِنَا ثُمَّ ذَكَرَ كَلاَمًا مَعْنَاهُ فَخَرَجَ رَسُولُ اللَّهِ صلى الله عليه وسلم لِيُصَلِّيَ بِنَا فَقَالَ ‏"‏ قُلْ ‏"‏ ‏.‏ فَقُلْتُ مَا أَقُولُ قَالَ ‏"‏ ‏{‏ قُلْ هُوَ اللَّهُ أَحَدٌ ‏}‏ وَالْمُعَوِّذَتَيْنِ حِينَ تُمْسِي وَحِينَ تُصْبِحُ ثَلاَثًا يَكْفِيكَ كُلَّ شَىْءٍ ‏"‏ ‏.‏

It was narrated from Mu'adh bin 'Abdullah that his father said:"It was raining and dark, and we were waiting for the Messenger of Allah [SAW] to lead us in prayer. Then the Messenger of Allah [SAW] came out to lead us in prayer and he said: 'Say.' I said: 'What should I say?' He said: 'Say: He is Allah, (the) One and Al-Mu'awwadhatain in the evening and in the morning, three times, and that will suffice you against everything

Sunan an-Nasa'i 5430Seeking Refuge With Allahfiled here by the compiler

أَخْبَرَنَا مُحَمَّدُ بْنُ عَلِيٍّ، قَالَ حَدَّثَنِي الْقَعْنَبِيُّ، عَنْ عَبْدِ الْعَزِيزِ، عَنْ عَبْدِ اللَّهِ بْنِ سُلَيْمَانَ، عَنْ مُعَاذِ بْنِ عَبْدِ اللَّهِ بْنِ خُبَيْبٍ، عَنْ أَبِيهِ، عَنْ عُقْبَةَ بْنِ عَامِرٍ الْجُهَنِيِّ، قَالَ بَيْنَا أَنَا أَقُودُ، بِرَسُولِ اللَّهِ صلى الله عليه وسلم رَاحِلَتَهُ فِي غَزْوَةٍ إِذْ قَالَ ‏"‏ يَا عُقْبَةُ قُلْ ‏"‏ ‏.‏ فَاسْتَمَعْتُ ثُمَّ قَالَ ‏"‏ يَا عُقْبَةُ قُلْ ‏"‏ ‏.‏ فَاسْتَمَعْتُ فَقَالَهَا الثَّالِثَةَ فَقُلْتُ مَا أَقُولُ فَقَالَ ‏"‏ ‏{‏ قُلْ هُوَ اللَّهُ أَحَدٌ ‏}‏ ‏"‏ ‏.‏ فَقَرَأَ السُّورَةَ حَتَّى خَتَمَهَا ثُمَّ قَرَأَ ‏{‏ قُلْ أَعُوذُ بِرَبِّ الْفَلَقِ ‏}‏ وَقَرَأْتُ مَعَهُ حَتَّى خَتَمَهَا ثُمَّ قَرَأَ ‏{‏ قُلْ أَعُوذُ بِرَبِّ النَّاسِ ‏}‏ فَقَرَأْتُ مَعَهُ حَتَّى خَتَمَهَا ثُمَّ قَالَ ‏"‏ مَا تَعَوَّذَ بِمِثْلِهِنَّ أَحَدٌ ‏"‏ ‏.‏

It was narrated that 'Uqbah bin 'Amir Al-Juhani said:"While I was leading the Messenger of Allah [SAW] on his mount on a military campaign, he said: 'O 'Uqbah, say!' I listened, then he said: 'O 'Uqbah, say!' I listened, then he said it a third time. I said: 'What should I say?' He said: 'Say: He is Allah, (the) One...' and he recited the Surah to the end. Then he recited: 'Say: I seek refuge with (Allah) the Lord of the daybreak...' and I recited it with him until the end. Then he recited: 'Say: I seek refuge with (Allah) the Lord of mankind...' and I recited it with him until the end. Then he said: 'No one ever sought refuge (with Allah) by means of anything like them

Jami' at-Tirmidhi 3370Remembrance, Supplication and Repentancefiled here by the compiler

حَدَّثَنَا عَبَّاسُ بْنُ عَبْدِ الْعَظِيمِ الْعَنْبَرِيُّ، وَغَيْرُ، وَاحِدٍ، قَالُوا حَدَّثَنَا أَبُو دَاوُدَ الطَّيَالِسِيُّ، حَدَّثَنَا عِمْرَانُ الْقَطَّانُ، عَنْ قَتَادَةَ، عَنْ سَعِيدِ بْنِ أَبِي الْحَسَنِ، عَنْ أَبِي هُرَيْرَةَ، رضى الله عنه عَنِ النَّبِيِّ صلى الله عليه وسلم قَالَ ‏ "‏ لَيْسَ شَيْءٌ أَكْرَمَ عَلَى اللَّهِ تَعَالَى مِنَ الدُّعَاءِ ‏"‏ ‏.‏ قَالَ أَبُو عِيسَى هَذَا حَدِيثٌ حَسَنٌ غَرِيبٌ لاَ نَعْرِفُهُ مَرْفُوعًا إِلاَّ مِنْ حَدِيثِ عِمْرَانَ الْقَطَّانِ وَعِمْرَانُ الْقَطَّانُ هُوَ ابْنُ دَاوَرَ وَيُكْنَى أَبَا الْعَوَّامِ ‏.‏ حَدَّثَنَا مُحَمَّدُ بْنُ بَشَّارٍ، حَدَّثَنَا عَبْدُ الرَّحْمَنِ بْنُ مَهْدِيٍّ، عَنْ عِمْرَانَ الْقَطَّانِ، بِهَذَا الإِسْنَادِ نَحْوَهُ ‏.‏

Abu Hurairah narrated that:The Prophet said: “There is nothing more honorable with Allah [Most High] than supplication.”

Jami' at-Tirmidhi 3372Remembrance, Supplication and Repentancefiled here by the compiler

حَدَّثَنَا أَحْمَدُ بْنُ مَنِيعٍ، حَدَّثَنَا مَرْوَانُ بْنُ مُعَاوِيَةَ، عَنِ الأَعْمَشِ، عَنْ ذَرٍّ، عَنْ يُسَيْعٍ، عَنِ النُّعْمَانِ بْنِ بَشِيرٍ، عَنِ النَّبِيِّ صلى الله عليه وسلم قَالَ ‏"‏ الدُّعَاءُ هُوَ الْعِبَادَةُ ‏"‏ ‏.‏ ثُمَّ قَرَأََ ‏:‏ ‏(‏وقالَ رَبُّكُمُ ادْعُونِي أَسْتَجِبْ لَكُمْ إِنَّ الَّذِينَ يَسْتَكْبِرُونَ عَنْ عِبَادَتِي سَيَدْخُلُونَ جَهَنَّمَ دَاخِرِينَ ‏)‏ ‏.‏ قَالَ هَذَا حَدِيثٌ حَسَنٌ صَحِيحٌ ‏.‏ وَقَدْ رَوَاهُ مَنْصُورٌ وَالأَعْمَشُ عَنْ ذَرٍّ وَلاَ نَعْرِفُهُ إِلاَّ مِنْ حَدِيثِ ذَرٍّ ‏.‏ هُوَ ذَرُّ بْنُ عَبْدِ اللَّهِ الْهَمْدَانِيُّ ثِقَةٌ وَالِدُ عُمَرَ بْنِ ذَرٍّ ‏.‏

An-Nu`man bin Bashir narrated that:The Prophet said: “The supplication, is worship.” Then he recited: And Your Lord said: “Call upon me, I will respond to you. Verily, those who scorn My worship, they will surely enter Hell humiliated

Classical works

كتب التراث6 shown

Arabic originals, reached through the subject’s Arabic senses. Interpretive sources, never proof of a ruling.

ruh §1508ruhArabic sense: الجزع, الهلع, جزع, هلع

حبس النفس عن الجزع والهلع والتشكي فيحبس النفس عن التسخط واللسان عن الشكوى والجوراح عما لا ينبغي فعله وهو ثبات القلب على الأحكام القدرية والشرعية

ruh §1492ruhArabic sense: الجزع, الهلع, جزع, هلع

وأما الشح فهو خلق ذميم يتولد من سوء الظن وضعف النفس ويمده وعد الشيطان حتى يصير هلعا والهلع شدة الحرص على الشيء والشره به فتولد عنه المنع لبذله والجزع لفقده كما قال تعالى @QB@ إن الإنسان خلق هلوعا إذا مسه الشر جزوعا وإذا مسه الخير منوعا @QE@

uddat-sabirin §930uddat-sabirinArabic sense: الجزع, الهلع, جزع, هلع

ويضاد الصبر الهلع وهو الجزع عند ورود المصيبة والمنع عند ورود النعمة قال تعالى @QB@ إن الإنسان خلق هلوعا إذا مسه الشر جزوعا وإذا مسه الخير منوعا @QE@ وهذا تفسير الهلوع قال الجوهرى الهلع أفحش الجزع وقد هلع بالكسر فهو هلع وهلوع وفى الحديث شر ما فى العبد شح هالع وجبن خالع

riyad-salihin §648riyad-salihinArabic sense: الجزع, الهلع, جزع, هلع

526 وعن عمرو بن تغلب بفتح التاء المثناة فوق وإسكان الغين المعجمة وكسر اللام رضي الله عنه أن رسول الله صلى الله عليه وسلم أتي بمال أو سبي فقسمه فأعطى رجالا وترك رجالا فبلغه أن الذين ترك عتبوا فحمد الله ثم أثنى عليه ثم قال أما بعد فوالله إني لأعطي الرجل وأدع الرجل والذي أدع أحب إلي من الذي أعطي ولكني إنما أعطي أقواما لما أرى في قلوبهم من الجزع والهلع وأكل أقواما إلى ما جعل الله في قلوبهم من الغني والخير منهم عمرو بن تغلب قال عمرو بن تغلب فوالله ما أحب أن لي بكلمة رسول الله صلى الله عليه وسلم حمر النعم رواه البخاري الهلع هو أشد الجزع وقيل الضجر

jawab-kafi §134jawab-kafiArabic sense: الجزع, الهلع, جزع, هلع

وأما السبعية فذنوب العدوان والغضب وسفك الدماء والتوثب على الضعفاء والعاجزين ويتولد منها أنواع أذي النوع الإنساني والجرأة على الظلم والعدوان وأما الذنوب البهيمية فمثل الشرة والحرص علي قضاء شهوة البطن والفرج ومنها يتولد الزنا والسرقة وأكل أموال اليتامى والبخل والشح والجبن والهلع والجزع وغير ذلك وهذا القسم أكثر ذنوب الخلق لعجزهم عن الذنوب السبعية والملكية ومنه يدخلون إلى سائر الأقسام فهو يجرهم إليها بزمام فيدخلون منه إلى الذنوب السبعية ثم إلي الشيطانية ثم منازعة الربوبية والشرك فى الوحدانية ومن تأمل هذا حق التأمل تبين له ان الذنوب دهليز الشرك والكفر ومنازعة الله ربوبية فصل

uddat-sabirin §56uddat-sabirinArabic sense: الجزع, الهلع, جزع, هلع

وفعل هذا الباب صبرت أصبر بالفتح في الماضي والكسر في المستقبل وأما صبرت أصبر بالضم في المستقبل فهو بمعنى الكفالة والصبير الكفيل كأنه حبس نفسه للغرم ومنه قولهم أصبرنى أي جعلني كفيلا وقيل أصل الكلمة من الشدة والقوة ومنه الصبر للدواء المعروف لشدة مرارته وكراهته قال الأصمعى إذا لقي الرجل الشدة بكمالها قيل لقيها بأصبارها ومنه الصبر بضم الصاد للأرض ذات الحصب لشدتها وصلابتها ومنه سميت الحرة أم صبار ومنه قولهم وقع القوم في أمر صبور بتشديد الباء أي أمر شديد ومنه صبارة الشتاء بتخفيف الباء وتشديد الراء لشدة برده وقيل مأخوذ من الجمع والضم فالصابر يجمع نفسه ويضمها عن الهلع والجزع ومنه صبرة الطعام وصبارة الحجارة

Research library

المكتبة البحثية4,916 works held

Peer-reviewed work held with its DOI and abstract, labelled with the study design its publication types report. None of it has been read or assessed, so nothing here may be cited as showing anything. Retracted work is held for the record but never listed; a review that a later version replaced is listed under its replacement and marked.

10.1016/j.euroneuro.2021.08.265European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (2021)MEDLINE-indexed journal, not yet read by us; matched on Anxiety, Anxiety Disorders, Anxiety, Separation, anxiety symptoms

The cognitive anxiety sensitivity treatment (CAST) in anxiety prevention - Focus on separation anxiety and interoception.: Given the high prevalence and considerable clinical and societal burden of anxiety disorders, preventive measures are urgently warranted to reduce their incidence and overall healthcare impact. Anxiety sensitivity (AS) - a key element in learning theories of anxiety disorders in the context of interoceptive conditioning - constitutes a malleable risk factor of particularly panic disorder and separation anxiety, which share developmental, nosological, epidemiological and pathomechanistic characte

10.1016/j.jad.2020.12.020Journal of affective disorders (2021)MEDLINE-indexed journal, not yet read by us; matched on Anxiety, Anxiety Disorders, anxiety symptoms, generalized anxiety, worry

Resistance exercise training among young adults with analogue generalized anxiety disorder.: Introduction: The objective of this randomized controlled trial (RCT) was to quantify the effects of eight weeks of World Health Organization and American College of Sports Medicine guidelines-based resistance exercise training (RET) among participants meeting criteria for subclinical, or analogue-GAD (AGAD) METHODS: Forty-four participants (mean age (y): 25.4.6±4.9.2) were randomized to either an eight-week, fully-supervised, one-on-one RET intervention or wait-list control. AGAD status was det

10.1038/s41380-023-02369-5Molecular psychiatry (2024)MEDLINE-indexed journal, not yet read by us; matched on Anxiety, Anxiety Disorders, anxiety symptoms, generalized anxiety, worry

A network model of depressive and anxiety symptoms: a statistical evaluation.: Background: Although network analysis studies of psychiatric syndromes have increased in recent years, most have emphasized centrality symptoms and robust edges. Broadening the focus to include bridge symptoms within a systematic review could help to elucidate symptoms having the strongest links in network models of psychiatric syndromes. We conducted this systematic review and statistical evaluation of network analyses on depressive and anxiety symptoms to identify the most central symptoms and

10.1016/j.janxdis.2014.09.022Journal of anxiety disorders (2014)MEDLINE-indexed journal, not yet read by us; matched on Anxiety, Anxiety Disorders, Phobic Disorders, generalized anxiety

Experience sampling and ecological momentary assessment for studying the daily lives of patients with anxiety disorders: a systematic review.: Anxiety disorders are highly prevalent. Symptoms may occur unpredictably (e.g., panic attacks) or predictably in specific situations (e.g., social phobia). Consequently, it may be difficult to assess anxiety and related constructs realistically in the laboratory or by traditional retrospective questionnaires. Experience sampling methods (ESM) and ecological momentary assessment (EMA) can deepen the understanding of the course of anxiety disorders by frequently assessing symptoms and other variab

10.1002/14651858.cd007505.pub2The Cochrane database of systematic reviews (2015)MEDLINE-indexed journal, not yet read by us; matched on Anxiety, Anxiety Disorders, anxiety symptoms, generalized anxiety

Pharmacotherapy for anxiety and comorbid alcohol use disorders.: Background: Anxiety disorders are a potentially disabling group of disorders that frequently co-occur with alcohol use disorders. Comorbid anxiety and alcohol use disorders are associated with poorer outcomes, and are difficult to treat with standard psychosocial interventions. In addition, improved understanding of the biological basis of the conditions has contributed to a growing interest in the use of medications for the treatment of people with both diagnoses. Objectives: To assess the effe

10.1016/j.janxdis.2023.102729Journal of anxiety disorders (2023)MEDLINE-indexed journal, not yet read by us; matched on Anxiety, Anxiety Disorders, generalized anxiety, worry

The impact of psychological treatment on intolerance of uncertainty in generalized anxiety disorder: A systematic review and meta-analysis.: Research has demonstrated a strong link between intolerance of uncertainty and generalized anxiety disorder (GAD). The current systematic review and meta-analysis aimed to evaluate how effective evidence-based psychological treatments are at reducing intolerance of uncertainty for adults with GAD. An extensive literature search identified 26 eligible studies, with a total of 1199 participants with GAD. Psychological treatments (k = 32 treatment groups) yielded large significant within-group effe

Research library, full list

4201 to 4225 of 4,916
Shekleton JA, Parcell DL, Redman JR, Phipps-Nelson J, Ponsford JL, Rajaratnam SM (2010)MEDLINE-indexed journal, not yet read by usNeurology159 citations

Sleep disturbance and melatonin levels following traumatic brain injury.

Objectives: Sleep disturbances commonly follow traumatic brain injury (TBI) and contribute to ongoing disability. However, there are no conclusive findings regarding specific changes to sleep quality and sleep architecture measured using polysomnography. Possible causes of the sleep disturbances include disruption of circadian regulation of sleep-wakefulness, psychological distress, and a neuronal response to injury. We investigated sleep-wake disturbances and their underlying mechanisms in a TBI patient sample. Methods: This was an observational study comparing 23 patients with TBI (429.7 +/- 287.6 days post injury) and 23 age- and gender-matched healthy volunteers on polysomnographic sleep measures, salivary dim light melatonin onset (DLMO) time, and self-reported sleep quality, anxiety, and depression. Results: Patients with TBI reported higher anxiety and depressive symptoms and slee

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Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls.

Accelerated leukocyte telomere shortening has been previously associated to self-perceived stress and psychiatric disorders, including schizophrenia and mood disorders. We set out to investigate whether telomere length is affected in patients with anxiety disorders in which stress is a known risk factor. We also studied the effects of childhood and recent psychological distress on telomere length. We utilized samples from the nationally representative population-based Health 2000 Survey that was carried out between 2000-2001 in Finland to assess major public health problems and their determinants. We measured the relative telomere length of the peripheral blood cells by quantitative real-time PCR from 321 individuals with DSM-IV anxiety disorder or subthreshold diagnosis and 653 matched controls aged 30-87 years, who all had undergone the Composite International Diagnostic Interview. Whi

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Lee MS, Kim JH, Park MS, Yang J, Ko YH, Ko SD, Joe SH (2010)MEDLINE-indexed journal, not yet read by usJournal of Korean medical science55 citations

Factors influencing the severity of menopause symptoms in Korean post-menopausal women.

We have relatively limited knowledge of symptomatic aspects of the postmenopause, rather than perimenopause. We tried to determine the factors associated with experiencing menopausal symptoms by Korean postmenopausal women. A total of 657 Korean women who underwent a natural menopause completed multiple questionnaires, which included questions regarding their attitudes to menopause, depressive symptoms, state anxiety, self-esteem, dyadic relationships, sociodemographic variables, and 11-item Menopause Rating Scale (MRS). Multiple regression analyses were performed to collectively examine the relative impact of each independent variable on the quality of life, as determined by the MRS. Decreased severity of menopausal symptoms was associated with more time spent in education, an employed status, a history of pregnancy, longer postmenopausal duration, positive attitudes to menopause, highe

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Simpson JA, Rholes WS, Winterheld HA (2010)MEDLINE-indexed journal, not yet read by usPsychological science24 citations

Attachment working models twist memories of relationship events.

The information that people remember about their relationships should be affected by their attachment orientations. This study investigated changes in individuals' memories of their own behavior during conflict-resolution discussions with their romantic partners. One week after each couple engaged in two videotaped conflict discussions, each partner's memory of the discussions was assessed. Memory biases were systematically related to attachment orientations. More avoidant individuals, for example, remembered being less supportive than they reported initially if they were relatively distressed during the discussions, whereas the opposite was true of less avoidant persons. More anxious individuals remembered being less emotionally distant than they reported initially if they were relatively distressed during the discussions, whereas the opposite was true of less anxious persons. We discus

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Jimenez C, Navia-Osorio PM, Diaz CV (2010)MEDLINE-indexed journal, not yet read by usJournal of advanced nursing158 citations

Stress and health in novice and experienced nursing students.

Aim: This paper is a report of a study conducted to identify the differences in novice and experienced nursing students' reports of stress and health. Background: Stress from clinical practice and its impact are international yet culturally mediated phenomena. Nursing students are under considerable stress during clinical practice periods, putting their education and health at risk. However, there is little or no empirical evidence about the stress suffered by nursing students and its impact on their health throughout clinical practice. Methods: We performed cross-sectional research using standard information gathering tools. This study was carried out with 357 students from all 3 years of a nursing diploma programme at a Spanish nursing college (71% response rate). The data were collected over an 8-month period in 2004-2005. Findings: We identified three types of stressors (clinical, ac

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Hayes J, Koo J (2010)MEDLINE-indexed journal, not yet read by usDermatologic therapy97 citations

Psoriasis: depression, anxiety, smoking, and drinking habits.

Psoriasis is a chronic disease that can negatively impact many aspects of quality of life. Patients with psoriasis may suffer from pain and discomfort from the disease as well as psychological and social difficulties including stigmatization, embarrassment, and social inhibition. Anxiety, depression, smoking, and alcohol abuse have been found to have a higher prevalence among psoriasis patients than healthy controls. These comorbidities have also been found to have a directly negative impact on psoriasis. Awareness of the relationship between psoriasis, psychiatric disorders, and substance abuse is important for dermatologists, as these comorbidities can lead to poor compliance and treatment outcomes.

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Kupferschmidt DA, Funk D, Erb S, Lê AD (2010)MEDLINE-indexed journal, not yet read by usBehavioural brain research15 citations

Age-related effects of acute nicotine on behavioural and neuronal measures of anxiety.

Adolescence is considered a period of enhanced vulnerability to the initiation of tobacco use. Biological differences in the sensitivity of adolescents and adults to the anxiogenic and anxiolytic effects of nicotine may contribute to this heightened vulnerability. Here, we investigated the age-dependency of the effects of acute nicotine on anxiety-related behaviour and neurotransmission. In Experiment 1, male adolescent (P33-37) and adult (P65-69) Long-Evans rats received nicotine (0, 0.4 or 0.8 mg/kg,s.c.) prior to testing using two measures of anxiety, the elevated plus maze (EPM) and light-dark (LD) transition box. In Experiment 2, in situ hybridization was used to assess, in different male adolescent and adult rats, CRF mRNA expression in the BNST, PVN and CeA in response to acute nicotine. In the EPM, adult rats displayed less anxious behaviour than adolescents. Nicotine (0.4, 0.8 m

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Nappi RE, Albani F, Santamaria V, Tonani S, Magri F, Martini E, Chiovato L, Polatti F (2010)MEDLINE-indexed journal, not yet read by usMaturitas44 citations

Hormonal and psycho-relational aspects of sexual function during menopausal transition and at early menopause.

Objective: The aim of the present observational, cross-sectional study was to examine the effects of hormonal and psycho-relational variables on sexual function during menopausal transition and at early postmenopause in women with hot flushes. Study design: The sample comprised 138 women referred to a clinic for the treatment of hot flushes. They were categorised according to their stage of menopausal transition using the STRAW criteria: early menopausal transition (EMT) if their menstrual cycle was 7 or more days different from normal; late perimenopause (LMT) if they had experienced 60 days or more of amenorrhoea; and early postmenopause (EPM) if their amenorrhoea had lasted for at least 12 months but less than 4 years. Main outcome measures: Sexual function was measured by using the Female Sexual Function Index (FSFI), while anxiety (state and trait), depression, eating disorder and m

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Rotllant D, Márquez C, Nadal R, Armario A (2010)MEDLINE-indexed journal, not yet read by usNeuroscience29 citations

The brain pattern of c-fos induction by two doses of amphetamine suggests different brain processing pathways and minor contribution of behavioural traits.

Previous studies have shown that amphetamine (AMPH) markedly activates dopaminergic projection areas, together with some important limbic nuclei. However, a global picture of the brain areas activated is lacking and the contribution of the dose of the drug and individual differences to this global brain activation is not known. In the present experiment, we studied in adult male rats the c-fos expression induced by two doses of AMPH (1.5 and 5 mg/kg sc) in a wide range of brain areas, and investigated the possible contribution of novelty-induced activity and anxiety traits. AMPH administration increased Fos+ neurons in an important number of telencephalic, diencephalic and brainstem areas. Interestingly, the ventral tegmental area (VTA) and the dorsal raphe nucleus were activated by the drug, but c-fos expression was restricted to non-dopaminergic and non-serotoninergic neurons, those ac

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Butterworth P, Pymont C, Rodgers B, Windsor TD, Anstey KJ (2010)MEDLINE-indexed journal, not yet read by usThe Australian and New Zealand journal of psychiatry36 citations

Factors that explain the poorer mental health of caregivers: Results from a community survey of older Australians.

Objectives: To contrast the level of anxiety and depression reported by older Australians providing assistance to someone who is ill, disabled or elderly with that of non-caregivers; and to identify secondary stressors and mediating factors which explain caregivers' poorer mental health. Method: Analysis of data from wave 2 of the PATH Through Life Study, a community survey of 2,222 adults aged 64-69 years conducted in Canberra and Queanbeyan, Australia. Mental health was assessed using the Goldberg depression and anxiety scales. Analyses focused on those who identified themselves as a primary carer and/or reported providing care for more than 5 hours per week. Analyses evaluated whether the association between caregiver status and mental health was mediated by financial factors, role strain, physical health, and social support and conflict with family and friends after adjusting for dem

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Beck KD, Jiao X, Pang KC, Servatius RJ (2010)MEDLINE-indexed journal, not yet read by usProgress in neuro-psychopharmacology & biological psychiatry37 citations

Vulnerability factors in anxiety determined through differences in active-avoidance behavior.

The risk for developing anxiety disorders is greater in females and those individuals exhibiting a behaviorally inhibited temperament. Growth of behavioral avoidance in people is a significant predictor of symptom severity in anxiety disorders, including post-traumatic stress disorder. Using an animal model, our lab is examining how the process of learning avoidant behavior may lead certain individuals to develop anxiety. Here we examined whether the known vulnerabilities of female sex and behaviorally inhibited temperament have individual or additive effects upon the acquisition of an active-avoidance response. A discrete trial lever-press escape-avoidance protocol was used to examine the acquisition of behavioral avoidance in male and female Sprague-Dawley (SD) rats and behaviorally inhibited inbred Wistar-Kyoto (WKY) rats. Overall, WKY rats of both sexes were indistinguishable in thei

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Fink P, Ørnbøl E, Christensen KS (2010)MEDLINE-indexed journal, not yet read by usPloS one133 citations

The outcome of health anxiety in primary care. A two-year follow-up study on health care costs and self-rated health.

Background: Hypochondriasis is prevalent in primary care, but the diagnosis is hampered by its stigmatizing label and lack of valid diagnostic criteria. Recently, new empirically established criteria for Health anxiety were introduced. Little is known about Health anxiety's impact on longitudinal outcome, and this study aimed to examine impact on self-rated health and health care costs. Methodology/principal findings: 1785 consecutive primary care patients aged 18-65 consulting their family physicians (FPs) for a new illness were followed-up for two years. A stratified subsample of 701 patients was assessed by the Schedules for Clinical Assessment in Neuropsychiatry interview. Patients with mild (N = 21) and severe Health anxiety (N = 81) and Hypochondriasis according to the DSM-IV (N = 59) were compared with a comparison group of patients who had a well-defined medical condition accordi

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Spinhoven P, Elzinga BM, Hovens JG, Roelofs K, Zitman FG, van Oppen P, Penninx BW (2010)MEDLINE-indexed journal, not yet read by usJournal of affective disorders189 citations

The specificity of childhood adversities and negative life events across the life span to anxiety and depressive disorders.

Background: Although several studies have shown that life adversities play an important role in the etiology and maintenance of both depressive and anxiety disorders, little is known about the relative specificity of several types of life adversities to different forms of depressive and anxiety disorder and the concurrent role of neuroticism. Few studies have investigated whether clustering of life adversities or comorbidity of psychiatric disorders critically influence these relationships. Methods: Using data from the Netherlands Study of Depression and Anxiety (NESDA), we analyzed the association of childhood adversities and negative life experiences across the lifespan with lifetime DSM-IV-based diagnoses of depression or anxiety among 2288 participants with at least one affective disorder. Results: Controlling for comorbidity and clustering of adversities the association of childhood

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Licht CM, Vreeburg SA, van Reedt Dortland AK, Giltay EJ, Hoogendijk WJ, DeRijk RH, Vogelzangs N, Zitman FG, de Geus EJ, Penninx BW (2010)MEDLINE-indexed journal, not yet read by usThe Journal of clinical endocrinology and metabolism172 citations

Increased sympathetic and decreased parasympathetic activity rather than changes in hypothalamic-pituitary-adrenal axis activity is associated with metabolic abnormalities.

Context: Stress is suggested to lead to metabolic dysregulations as clustered in the metabolic syndrome, but the underlying biological mechanisms are not yet well understood. Objective: We examined the relationship between two main str systems, the autonomic nervous system and the hypothalamic-pituitary-adrenal (HPA) axis, with the metabolic syndrome and its components. Design: The design was baseline data (yr 2004-2007) of a prospective cohort: the Netherlands Study of Depression and Anxiety (NESDA). Setting: The study comprised general community, primary care, and specialized mental health care. Participants: This study included 1883 participants aged 18-65 yr. Main outcome measures: Autonomic nervous system measures included heart rate, respiratory sinus arrhythmia (RSA; high RSA reflecting high parasympathetic activity), and preejection period (PEP; high PEP reflecting low sympatheti

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Kazak AE, Derosa BW, Schwartz LA, Hobbie W, Carlson C, Ittenbach RF, Mao JJ, Ginsberg JP (2010)MEDLINE-indexed journal, not yet read by usJournal of clinical oncology : official journal of the American Society of Clinical Oncology188 citations

Psychological outcomes and health beliefs in adolescent and young adult survivors of childhood cancer and controls.

PURPOSE The purpose of this study was to compare adolescent and young adult (AYA) pediatric cancer survivors and peers without a history of serious illness on psychological distress, health-related quality of life (HRQOL), health beliefs; examine age at diagnosis and cancer treatment intensity on these outcomes; and examine relationships between number of health problems and the outcomes. PATIENTS AND METHODS AYA cancer survivors (n = 167) and controls (n = 170), recruited during visits to a cancer survivorship clinic and primary care, completed self-report questionnaires of distress, health problems, and health beliefs. For survivors, providers rated treatment intensity and health problems. Results There were no statistically significant differences between survivors and controls in psychological distress or HRQOL. Cancer survivors had less positive health beliefs. Survivors diagnosed a

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Henselmans I, Helgeson VS, Seltman H, de Vries J, Sanderman R, Ranchor AV (2010)MEDLINE-indexed journal, not yet read by usHealth psychology : official journal of the Division of Health Psychology, American Psychological Association220 citations

Identification and prediction of distress trajectories in the first year after a breast cancer diagnosis.

Objective: In this article, we aim to (a) identify distinct trajectories of psychological distress in the first year after a breast cancer diagnosis in women treated with adjuvant therapy and (b) explore possible predictors of these trajectories, that is, demographic, medical, and personal characteristics. Method: The 171 patients were assessed after diagnosis, after surgery, after adjuvant treatment, in the reentry phase, and in the (short-term) survivorship phase (2 and 6 months after the end of treatment, respectively). Main outcome measure: Psychological distress was assessed with the 12-item General Health Questionnaire. Results: There were four trajectories of distress: a group that experienced no distress (36.3%), a group that experienced distress only in the active treatment phase (33.3%), a group that experienced distress in the reentry and survivorship phase (15.2%), and a grou

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Smeets T (2010)MEDLINE-indexed journal, not yet read by usBiological psychology56 citations

Autonomic and hypothalamic-pituitary-adrenal stress resilience: Impact of cardiac vagal tone.

Resilience refers to the ability to cope with stressful events. Variation in the activity of the stress-responsive sympatho-adrenal-medullary and hypothalamic-pituitary-adrenal axes is particularly important for adaptive stress responses and thus may give rise to individual differences in resilience. Here, we investigated whether cardiac vagal tone and adult attachment style are related to psychophysiological stress resilience by exposing a sample of healthy young men and women (n=68) to a laboratory stress test while monitoring autonomic (heart rate, salivary alpha-amylase), hypothalamic-pituitary-adrenal (salivary cortisol), and psychological stress levels. Our results demonstrate that adult attachment style did not influence autonomic, hypothalamic-pituitary-adrenal, or psychological stress responses. In contrast, higher resting cardiac vagal tone was associated with stress-induced in

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Wonderlich-Tierney AL, Vander Wal JS (2010)MEDLINE-indexed journal, not yet read by usEating behaviors45 citations

The effects of social support and coping on the relationship between social anxiety and eating disorders.

The current study examined the hypotheses that social support and coping moderate and or mediate the relationship between a broad and a narrow form of social anxiety and eating disorder symptoms. One hundred sixty-nine female undergraduates at a private Midwestern university, completed measures of social support, coping, social anxiety, fear of negative evaluation, and disordered eating attitudes and behaviors. Results of hierarchical multiple regression analyses indicated that higher levels of social support are associated with a weaker association between social anxiety and eating disorder symptomatology. Low use of task- and avoidant-oriented (distraction) coping and increased use of emotion-oriented coping are associated with a stronger association between social anxiety and eating disorder symptomatology. Implications for research and clinical intervention are discussed.

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Kastenbaum R, Heflick NA (2010)MEDLINE-indexed journal, not yet read by usOmega8 citations

Sad to say: is it time for Sorrow Management Theory?

Terror Management Theory (TMT) research often asks respondents to describe their personal death. This exposure enables the testing of hypotheses regarding defenses ("buffers") against the anxious awareness of death. Curiously, though, the respondents' narratives are not analyzed or reported. The present study offers a qualitative analysis of 209 college student narrative responses provided for this purpose by TMT researchers Jeff Greenberg and Nathan Heflick. The narratives are reviewed with attention to affect (adjectives), semantic structure, and theme. Many responses are marked by anxiety, but sorrow is also pervasive. Individual differences in response substance and structure invite further exploration. It is suggested that our understanding of the response to personal death threat could be enhanced by encompassing sorrow as well as anxiety within the same conceptual framework. Sever

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Goodman JH, Tyer-Viola L (2010)MEDLINE-indexed journal, not yet read by usJournal of women's health (2002)155 citations

Detection, treatment, and referral of perinatal depression and anxiety by obstetrical providers.

Aims: This study aimed to assess the rates of detection, treatment, and referral of maternal depression and anxiety by obstetrical providers during pregnancy and at 6 weeks postpartum. Methods: A convenience sample of women receiving obstetrical care at a large urban teaching hospital (n = 491) was screened for depression and anxiety during the third trimester of pregnancy and again at 6 weeks postpartum using the Edinburgh Postnatal Depression Scale and the anxiety portions of the Patient Health Questionnaire. Participants were also asked if they thought they needed help for depression, anxiety, or stress at the two time points. Obstetrical providers were blind to screening results. Two months postdelivery, each woman's obstetrical electronic medical record (EMR) was reviewed for documentation of psychiatric symptoms, diagnoses, psychiatric treatment, and mental health referrals at the

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McKenna G, Hevey D, Martin E (2010)MEDLINE-indexed journal, not yet read by usClinical psychology & psychotherapy16 citations

Patients' and providers' perspectives on bibliotherapy in primary care.

Bibliotherapy is a form of self-administered treatment in which structured materials provide a means to alleviate distress. Although the treatment has evidence of effectiveness, evaluations of bibliotherapy have typically focused on outcomes, and the perspectives of both the client and the service provider have been understudied. In the present study, eleven users of a bibliotherapy scheme were interviewed regarding their experiences of bibliotherapy. In addition, five referring practitioners to the scheme were also interviewed. Thematic analyses revealed three super-ordinate themes in the transcripts: participants' personal experiences of the bibliotherapy scheme factors that facilitate change and the influence of the professionals involved. The implications of these findings for bibliotherapy schemes are considered.

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Myhren H, Ekeberg O, Tøien K, Karlsson S, Stokland O (2010)MEDLINE-indexed journal, not yet read by usCritical care (London, England)194 citations

Posttraumatic stress, anxiety and depression symptoms in patients during the first year post intensive care unit discharge.

Introduction: To study the level and predictors of posttraumatic stress, anxiety and depression symptoms in medical, surgical and trauma patients during the first year post intensive care unit (ICU) discharge. Methods: Of 255 patients included, 194 participated at 12 months. Patients completed the Impact of Event Scale (IES), Hospital Anxiety and Depression Scale (HADS), Life Orientation Test (LOT) at 4 to 6 weeks, 3 and 12 months and ICU memory tool at the first assessment (baseline). Case level for posttraumatic stress symptoms with high probability of a posttraumatic stress disorder (PTSD) was > or = 35. Case level of HADS-Anxiety or Depression was > or = 11. Memory of pain during ICU stay was measured at baseline on a five-point Likert-scale (0-low to 4-high). Patient demographics and clinical variables were controlled for in logistic regression analyses. Results: Mean IES score one

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Felmingham K, Williams LM, Kemp AH, Liddell B, Falconer E, Peduto A, Bryant R (2010)MEDLINE-indexed journal, not yet read by usJournal of abnormal psychology124 citations

Neural responses to masked fear faces: sex differences and trauma exposure in posttraumatic stress disorder.

Although women have a greater propensity than men to develop posttraumatic stress disorder (PTSD) following trauma, sex differences in neural activations to threat have received little investigation. This study tested the prediction that trauma would heighten activity in automatic fear-processing networks to a greater extent in women than in men. Functional magnetic resonance imaging (fMRI) data were recorded in 23 participants with PTSD (13 women, 10 men), 21 trauma-exposed controls (9 women, 12 men), and 42 non-trauma-exposed controls (22 women, 20 men) while they viewed masked facial expressions of fear. Exposure to trauma was associated with enhanced brainstem activity to fear in women, regardless of the presence of PTSD, but in men, it was associated only with the development of PTSD. Men with PTSD displayed greater hippocampal activity to fear than did women. Both men and women wit

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Renshaw KD, Blais RK, Caska CM (2010)MEDLINE-indexed journal, not yet read by usBehavior therapy13 citations

Distinctions between hostile and nonhostile forms of perceived criticism from others.

Criticism and hostility from others are related to fluctuations in symptom severity across many disorders, including depression and anxiety. Objective coding systems typically allow for distinctions between criticism and hostility, but the primary self-report measure of perceptions of criticism (the Perceived Criticism Measure) contains no such distinction. This report presents results from two samples regarding the assessment of specific perceptions of hostile and nonhostile criticism. In addition to these specific perceptions, we assessed relationship satisfaction, perceptions of overall criticism, and symptoms of depression and anxiety. Perceptions of hostile criticism were similar to ratings of overall criticism, as indicated by a positive correlation between these two and similar correlations with related variables. In contrast, perceptions of nonhostile criticism demonstrated more

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Yoshida M, Takayanagi Y, Inoue K, Kimura T, Young LJ, Onaka T, Nishimori K (2009)MEDLINE-indexed journal, not yet read by usThe Journal of neuroscience : the official journal of the Society for Neuroscience483 citations

Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice.

The oxytocin receptor has been implicated in the regulation of reproductive physiology as well as social and emotional behaviors. The neurochemical mechanisms by which oxytocin receptor modulates social and emotional behavior remains elusive, in part because of a lack of sensitive and selective antibodies for cellular localization. To more precisely characterize oxytocin receptor-expressing neurons within the brain, we generated an oxytocin receptor-reporter mouse in which part of the oxytocin receptor gene was replaced with Venus cDNA (a variant of yellow fluorescent protein). Examination of the Venus expression revealed that, in the raphe nuclei, about one-half of tryptophan hydroxylase-immunoreactive neurons were positive for Venus, suggesting a potential role for oxytocin in the modulation of serotonin release. Oxytocin infusion facilitated serotonin release within the median raphe n

matched on Anxiety Disorders (mesh)

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