Growing old, frailty, and care of the elderly.
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Qurʾān
القرآن6 shownVerses named for this subject by hand come first. The rest are found by the subject’s own Arabic and English senses and are shown as lexical matches, not as anchors anyone has confirmed.
Qur'ān 16:70English sense: old age | Arabic sense: ارذل العمر
وَٱللَّهُ خَلَقَكُمۡ ثُمَّ يَتَوَفَّىٰكُمۡۚ وَمِنكُم مَّن يُرَدُّ إِلَىٰٓ أَرۡذَلِ ٱلۡعُمُرِ لِكَيۡ لَا يَعۡلَمَ بَعۡدَ عِلۡمࣲ شَيۡـًٔاۚ إِنَّ ٱللَّهَ عَلِيمࣱ قَدِيرࣱ
It is God who has created you and in time will cause you to die. Some of you will be reduced, in old age, to a most abject state, so that, after having knowledge, they will know nothing at all: God is truly all knowing and all powerful
Qur'ān 30:54Arabic sense: شيب | English sense: grey hair
۞ٱللَّهُ ٱلَّذِي خَلَقَكُم مِّن ضَعۡفࣲ ثُمَّ جَعَلَ مِنۢ بَعۡدِ ضَعۡفࣲ قُوَّةࣰ ثُمَّ جَعَلَ مِنۢ بَعۡدِ قُوَّةࣲ ضَعۡفࣰ ا وَشَيۡبَةࣰۚ يَخۡلُقُ مَا يَشَآءُۚ وَهُوَ ٱلۡعَلِيمُ ٱلۡقَدِيرُ
It is God who creates you weak, then gives you strength, then weakness after strength, together with your grey hair: He creates what He will; He is the All Knowing, the All Powerful
Qur'ān 22:5Arabic sense: ارذل العمر
يَٰٓأَيُّهَا ٱلنَّاسُ إِن كُنتُمۡ فِي رَيۡبࣲ مِّنَ ٱلۡبَعۡثِ فَإِنَّا خَلَقۡنَٰكُم مِّن تُرَابࣲ ثُمَّ مِن نُّطۡفَةࣲ ثُمَّ مِنۡ عَلَقَةࣲ ثُمَّ مِن مُّضۡغَةࣲ مُّخَلَّقَةࣲ وَغَيۡرِ مُخَلَّقَةࣲ لِّنُبَيِّنَ لَكُمۡۚ وَنُقِرُّ فِي ٱلۡأَرۡحَامِ مَا نَشَآءُ إِلَىٰٓ أَجَلࣲ مُّسَمࣰّ ى ثُمَّ نُخۡرِجُكُمۡ طِفۡلࣰ ا ثُمَّ لِتَبۡلُغُوٓاْ أَشُدَّكُمۡۖ وَمِنكُم مَّن يُتَوَفَّىٰ وَمِنكُم مَّن يُرَدُّ إِلَىٰٓ أَرۡذَلِ ٱلۡعُمُرِ لِكَيۡلَا يَعۡلَمَ مِنۢ بَعۡدِ عِلۡمࣲ شَيۡـࣰٔ اۚ وَتَرَى ٱلۡأَرۡضَ هَامِدَةࣰ فَإِذَآ أَنزَلۡنَا عَلَيۡهَا ٱلۡمَآءَ ٱهۡتَزَّتۡ وَرَبَتۡ وَأَنۢبَتَتۡ مِن كُلِّ زَوۡجِۭ بَهِيجࣲ
People, [remember,] if you doubt the Resurrection, that We created you from dust, then a drop of fluid, then a clinging form, then a lump of flesh, both shaped and unshaped: We mean to make Our power clear to you. Whatever We choose We cause to remain in the womb for an appointed time, then We bring you forth as infants and then you grow and reach maturity. Some die young and some are left to live on to such an age that they forget all they once knew. You sometimes see the earth lifeless, yet when We send down water it stirs and swells and produces every kind of joyous growth
Qur'ān 14:39English sense: old age
ٱلۡحَمۡدُ لِلَّهِ ٱلَّذِي وَهَبَ لِي عَلَى ٱلۡكِبَرِ إِسۡمَٰعِيلَ وَإِسۡحَٰقَۚ إِنَّ رَبِّي لَسَمِيعُ ٱلدُّعَآءِ
Praise be to God, who has granted me Ishmael and Isaac in my old age: my Lord hears all requests
Qur'ān 15:54English sense: old age
قَالَ أَبَشَّرۡتُمُونِي عَلَىٰٓ أَن مَّسَّنِيَ ٱلۡكِبَرُ فَبِمَ تُبَشِّرُونَ
He said, ‘How can you give me such news when old age has come to me? What sort of news is this?’
Qur'ān 2:266English sense: old age
أَيَوَدُّ أَحَدُكُمۡ أَن تَكُونَ لَهُۥ جَنَّةࣱ مِّن نَّخِيلࣲ وَأَعۡنَابࣲ تَجۡرِي مِن تَحۡتِهَا ٱلۡأَنۡهَٰرُ لَهُۥ فِيهَا مِن كُلِّ ٱلثَّمَرَٰتِ وَأَصَابَهُ ٱلۡكِبَرُ وَلَهُۥ ذُرِّيَّةࣱ ضُعَفَآءُ فَأَصَابَهَآ إِعۡصَارࣱ فِيهِ نَارࣱ فَٱحۡتَرَقَتۡۗ كَذَٰلِكَ يُبَيِّنُ ٱللَّهُ لَكُمُ ٱلۡأٓيَٰتِ لَعَلَّكُمۡ تَتَفَكَّرُونَ
Would any of you like to have a garden of palm trees and vines, graced with flowing streams and all kinds of produce, which, when you are afflicted with old age and feeble offspring, is struck by a fiery whirlwind and burnt down? In this way God makes His messages clear to you, so that you may reflect on them
Tafsīr
التفسير6 shownCommentary on the verses above, at most two editions per verse.
en-al-jalalayn on 16:70en-al-jalalayncommentary on an ayah this subject surfaced
And God has created you when you were nothing then He takes you in death when your terms of life are concluded; and there are some among you who are relegated to the most abject stage of life that is the most diminished because of old-age and senility so that he knows nothing after having possessed some knowledge. ‘Ikrima said ‘Whoever recites the Qur’ān will not come to such a predicament’. God is Knowing of how to manage the affairs of His creation Powerful in doing what He will.
en-tafisr-ibn-kathir on 16:70en-tafisr-ibn-kathircommentary on an ayah this subject surfaced
And Allah created you and then He will cause you to die; and among you there are some who are sent back to senility, so that they know nothing after having known (much). Truly, Allah is Knowing, capable of all things (70)
In Man there is a Lesson
Allah tells us that He is controlling the affairs of His servants. He is the One Who created them out of nothing, then He will cause them to die. But there are some of them that He allows to grow old, which is a physical weakness, as Allah says:
اللَّهُ الَّذِي خَلَقَكُم مِّن ضَعْفٍ ثُمَّ جَعَلَ مِن بَعْدِ ضَعْفٍ قُوَّةً
(Allah is He Who created you in (a state of) weakness, then gave you strength after weakness, then after strength gave (you) weakness)(30:54)
لِكَيْ لَا يَعْلَمَ بَعْدَ عِلْمٍ شَيْئًا
(so that they know nothing after having known.) meaning, after he knew things, he will reach a stage where he knows nothing because of weakn
en-asbab-al-nuzul-by-al-wahidi on 22:5en-asbab-al-nuzul-by-al-wahidicommentary on an ayah this subject surfaced
O people, if you are in doubt about the Uprising, surely We created you of dust, then of a sperm drop, then of a blood clot, then of a lump of flesh, fully created and not fully created, that We might make clear to you. The composition of the Adamic body in the first creation is a clear argument against the deniers of the Uprising. He is saying, “I am the Lord who created a body and figure with such comeliness, a stature and form with such beauty, from that feeble sperm drop in that firm settledness. He says, “Did We not create you of feeble water, then put it in a firm settledness?” [77:20-21]. If you ponder this body, you will find an exemplar of all the created and newly arrived things in the celestial and terrestrial worlds. Just as He arranged the seven spheres in heaven, so also He composed seven parts in this body-water and dust, and then flesh, skin, veins, sinews, and bones. Jus
en-al-jalalayn on 30:54en-al-jalalayncommentary on an ayah this subject surfaced
God is the One Who created you from a state of weakness from a ‘base fluid’ cf. Q. 328 then He ordained after a second weakness which is the weakness of the period of childhood strength that is the strength of youth then after strength He appointed weakness again and grey hair the weakness of old age and the grey hairs of decrepitude read vocalised as du‘f ‘weakness’ in all three places. He creates what He will of weakness and strength youth and grey hairs and He is the Knower of how to manage His creatures the Omnipotent.
en-tafisr-ibn-kathir on 30:54en-tafisr-ibn-kathircommentary on an ayah this subject surfaced
Allah is He Who created you in weakness, then gave you strength after weakness, then after strength gave (you) weakness and grey hair. He creates what He wills. And He is the All-Knowing, the All-Powerful (54)
The Different Stages of Man
Here Allah points out how man passes through different stages of creation, one phase after another. He is originally created from dust, then from a Nutfah, then from a clot, then from a lump of flesh. Then he becomes bones, then the bones are clothed with flesh, then the soul is breathed into him. Then he emerges from his mother's womb, weak and thin and powerless. Then he grows up little by little, until he becomes a child, then he reaches the stage of puberty, then he becomes a young man, which is strength after weakness. Then he starts to get older, reaching middle age, then old age and senility, weakness after strength, so he loses his resolve, pow
en-al-jalalayn on 22:5en-al-jalalayncommentary on an ayah this subject surfaced
O mankind in other words O people of Mecca if you are in doubt about the Resurrection then lo! consider that We have created you that is We have created your origin — Adam — from dust then We created his progeny from a drop a sperm-drop then from a clot congealed blood then from a little lump of flesh mudgha a piece of flesh the size of what one would be able to chew mā yumdagh partly formed shaped complete in form and partly unformed that is uncomplete in form that We may make clear to you the perfect nature of Our power that you might then infer from this initial act of creation the reality of its future restoration. And We establish nuqirru marks a new grammatically independent sentence in the wombs whatever We will for a specified time that is until the time for it to come out then We bring you forth from the bellies of your mothers as infants and then We extend your life that you ma
Research library, full list
601 to 625 of 1,184Social inequalities in multimorbidity, frailty, disability, and transitions to mortality: a 24-year follow-up of the Whitehall II cohort study.
Background: Social inequalities in mortality persist in high-income countries with universal health care, and the mechanisms by which these inequalities are generated remain unclear. We aimed to examine whether social inequalities were present before or after the onset of adverse health conditions (multimorbidity, frailty, and disability).
Methods: Our analysis was based on data from the ongoing Whitehall II cohort study, which enrolled British civil servants aged 35-55 years in 1985-88. Participants were assessed for three indicators of socioeconomic status (education, occupational position, and literacy) at age 50 years. Participants underwent clinical examinations (in 2002-04, 2007-09, 2012-13, and 2015-16) for assessment of frailty (two or more of low physical activity, slow walking speed, poor grip strength, weight loss, and exhaustion) and disability (two or more difficulties in ba…
matched on Frail Elderly (mesh), Frailty (mesh)
Avgerinou C, Gardner B, Kharicha K, Frost R, Liljas A, Elaswarapu R, Manthorpe J, Drennan VM, Goodman C, Iliffe S, Walters K (2019)MEDLINE-indexed journal, not yet read by usHealth & social care in the community15 citations Health promotion for mild frailty based on behaviour change: Perceptions of older people and service providers.
Mild frailty is common among older people, but it is potentially reversible with health promotion interventions. Behaviour change may be a key to preventing progression of frailty; however, we know little about what interventions work best and how a behaviour change approach would be perceived by this group. The aim of this study was to explore how mildly frail older people perceive health promotion based on behaviour change and what factors affect engagement with this approach. We conducted semi-structured interviews with 16 older people with mild frailty who received a pilot home-based behaviour change health promotion service, including a dyad of older person/family carer, and two service providers delivering the service in two diverse areas of South England. Interviews were audio-recorded, transcribed and thematically analysed. The concept of goal setting was acceptable to most parti…
matched on Frail Elderly (mesh), Frailty (mesh)
Frailty Screening in the Community Using the FRAIL Scale.
Objectives: To explore the feasibility of using the FRAIL scale in community screening of older Chinese people aged 65 years and older, followed by clinical validation by comprehensive geriatric assessment of those classified as pre-frail or frail.
Design: Two-phase study: screening of people aged 65 years and older by trained volunteers, followed by comprehensive geriatric assessment by multidisciplinary staff for those classified as pre-frail or frail.
Setting: Elderly Centers in the New Territories East Region of Hong Kong SAR China.
Participants: A total of 816 members of elderly centers attending by themselves or accompanied by relatives.
Measurements: For phase 1, questionnaire (including demographic, lifestyle, chronic diseases) and screening tools were administered by trained volunteers. These consist of the FRAIL scale, SARC-F to screen for sarcopenia, and mild cognitive impairm…
matched on Frail Elderly (mesh), Geriatric Assessment (mesh)
Relationships between gender, age, family conditions, physical and mental health, and social isolation of elderly caregivers.
Background: In an aging population an increasing number of elderly caregivers will be called upon to provide care over a long period, during which time they will be burdened both by caregiving and by the physiological effects of their own aging. Among them there will be more aged male caregivers, who will probably be less prepared than women to become caregivers. The aim of this study was to investigate the relationship between caregivers' gender, age, family income, living arrangements and social support as independent variables, and depressive symptoms, comorbidities, level of frailty, grip strength, walking speed and social isolation, as dependent variables.
Methods: 176 elderly people (123 women) were selected from a sample of a population-based study on frailty (n = 900), who had cared for a spouse (79.3%) and/or parents (31.4%) in the past five years (mean age = 71.8 ± 4.86 years; …
matched on Frail Elderly (mesh), Geriatric Assessment (mesh)
Measurement properties of the Groningen Frailty Indicator in home-dwelling and institutionalized elderly people.
Objectives: To enable prevention of poor outcome in elderly people, a valid instrument is required to detect individuals at high risk. The concept of frailty is a better predictor than age alone. The Groningen Frailty Indicator (GFI) has been developed to identify frailty. We assessed feasibility, reliability, and construct validity of the self-assessment version of the GFI.
Design: Cross-sectional.
Setting: Community-based.
Participants: Home-dwelling and institutionalized elderly persons were included in the study (n = 353) who met the following inclusion criteria: persons 65 years and older who were able to fill out questionnaires.
Measurements: The feasibility of the GFI was assessed by determining the proportion of missing values per item. The internal consistency reliability of the GFI was established by calculating the KR-20. Mann-Whitney and Kruskal-Wallis tests were applied to a…
matched on Frail Elderly (mesh), Geriatric Assessment (mesh)
Prevalence of frailty in middle-aged and older community-dwelling Europeans living in 10 countries.
Background: Frailty is an indicator of health status in old age. Its frequency has been described mainly for North America; comparable data from other countries are lacking. Here we report on the prevalence of frailty in 10 European countries included in a population-based survey.
Methods: Cross-sectional analysis of 18,227 randomly selected community-dwelling individuals 50 years of age and older, enrolled in the Survey of Health, Aging and Retirement in Europe (SHARE) in 2004. Complete data for assessing a frailty phenotype (exhaustion, shrinking, weakness, slowness, and low physical activity) were available for 16,584 participants. Prevalences of frailty and prefrailty were estimated for individuals 50-64 years and 65 years of age and older from each country. The latter group was analyzed further after excluding disabled individuals. We estimated country effects in this subset using m…
matched on Frail Elderly (mesh), Geriatric Assessment (mesh)
Pohan RA (2024)editorial or commentMEDLINE-indexed journal, not yet read by usBrain, behavior, and immunity1 citations Improving the validity of studies on the relationship between social health and Immunity of older Adults: Letter to the editor.
The recent study by Isabelle F. van der Velpen et al., (2024), published in Brain Behavior and Immunity, explores the intricate relationship between social health, marital status, and their effects on immune markers and neurodegeneration in the elderly. It highlights significant gender and marital status differences impacting immune system health and plasma biomarkers. Despite its depth, the study's reliance on self-reported measures for loneliness and social support may not fully capture the complexity of social health, which includes dynamic components like social integration. The use of broad immune indices, such as the Granulocyte to Lymphocyte Ratio and Systemic Immune Inflammation index, limits the detailed understanding of specific immune pathways. The study's cross-sectional design restricts causal inferences, underscoring the need for longitudinal research to establish temporal …
matched on Aging (mesh), older adults (text)
Intelligence and socioeconomic position in childhood in relation to frailty and cumulative allostatic load in later life: the Lothian Birth Cohort 1936.
Background: Information on childhood determinants of frailty or allostatic load in later life is sparse. We investigated whether lower intelligence and greater socioeconomic disadvantage in childhood increased the risk of frailty and higher allostatic load, and explored the mediating roles of adult socioeconomic position, educational attainment and health behaviours.
Methods: Participants were 876 members of the Lothian Birth Cohort 1936 whose intelligence was assessed at age 11. At age 70, frailty was assessed using the Fried criteria. Measurements were made of fibrinogen, triglyceride, total and high-density lipoprotein cholesterol, albumin, glycated haemoglobin, C reactive protein, body mass index and blood pressure, from which an allostatic load score was calculated.
Results: In sex-adjusted analyses, lower intelligence and lower social class in childhood were associated with an incr…
matched on Frail Elderly (mesh), later life (text)
A social robot intervention on depression, loneliness, and quality of life for Taiwanese older adults in long-term care.
Objectives: To investigate the effect of a social robot intervention on depression, loneliness, and quality of life of older adults in long-term care (LTC) and to explore participants' experiences and perceptions after the intervention.
Design: A mixed-methods approach consisting of a single group, before and after quasi-experimental design, and individual interview.
Participants: Twenty older adults with depression from four LTC facilities in Taiwan were recruited.
Intervention: Each participant participated in 8 weeks of observation and 8 weeks of intervention. In the observation stage, participants received usual care or activities without any research intervention. In the intervention stage, each participant was given a Paro (Personal Assistive RobOt) to keep for 24 hours, 7 days a week.
Measurements: The Geriatric Depression Scale, the UCLA Loneliness Scale Version 3, and the World …
matched on Homes for the Aged (mesh), Geriatric Assessment (mesh), older adults (text)
Taylor LJ, Nabozny MJ, Steffens NM, Tucholka JL, Brasel KJ, Johnson SK, Zelenski A, Rathouz PJ, Zhao Q, Kwekkeboom KL, Campbell TC, Schwarze ML (2017)MEDLINE-indexed journal, not yet read by usJAMA surgery139 citations A Framework to Improve Surgeon Communication in High-Stakes Surgical Decisions: Best Case/Worst Case.
Importance: Although many older adults prefer to avoid burdensome interventions with limited ability to preserve their functional status, aggressive treatments, including surgery, are common near the end of life. Shared decision making is critical to achieve value-concordant treatment decisions and minimize unwanted care. However, communication in the acute inpatient setting is challenging.
Objective: To evaluate the proof of concept of an intervention to teach surgeons to use the Best Case/Worst Case framework as a strategy to change surgeon communication and promote shared decision making during high-stakes surgical decisions.
Design, setting, and participants: Our prospective pre-post study was conducted from June 2014 to August 2015, and data were analyzed using a mixed methods approach. The data were drawn from decision-making conversations between 32 older inpatients with an acute …
matched on Frail Elderly (mesh), older adults (text)
Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Uemura K, Ito T, Lee S, Park H, Suzuki T (2013)MEDLINE-indexed journal, not yet read by usJournal of the American Medical Directors Association342 citations Combined prevalence of frailty and mild cognitive impairment in a population of elderly Japanese people.
Objective: Preventive strategies for frailty and mild cognitive impairment (MCI) are important for avoiding future functional decline and dementia in older adults. The purpose of this study was to use a population-based survey to ascertain the single and combined prevalence of frailty and MCI and to identify the relationships between frailty and MCI in older Japanese adults.
Design: Cross-sectional study.
Setting: General community.
Participants: A total of 5104 older adults (aged 65 years or older, mean age 71 years) who were enrolled in the Obu Study of Health Promotion for the Elderly (OSHPE).
Measurements: Each participant underwent detailed physical and cognitive testing to assess frailty and MCI. We considered the frailty phenotype to be characterized by limitations in 3 or more of the following 5 domains: mobility, strength, endurance, physical activity, and nutrition. Screening f…
matched on Frail Elderly (mesh), older adults (text)
Health despite frailty: exploring influences on frail older adults' experiences of health.
The aim of this study was to explore and identify influences on frail older adults' experience of health. A sample of older adults, 11 men and 11 women aged 67-92, with diverse ratings of self-perceived health ranging from poor to excellent were selected through a purposeful strategic sampling of frail older adults taken from a broader sample from a quantitative study on health. In total, 22 individual qualitative interviews were analyzed using qualitative content analysis in which themes were developed from raw data through a systematic reading, categorization of selected text, theme development and interpretation. To feel assured and capable was the main theme, which consisted of five subthemes: managing the unpredictable body, reinforcing a positive outlook, remaining in familiar surroundings, managing everyday life, and having a sense of belonging and connection to the whole. The imp…
matched on Frail Elderly (mesh), older adults (text)
Pain and psychological well-being of older persons living in nursing homes: an exploratory study in planning patient-centred intervention.
Aim: This article is a report on a study to examine the pain situation, the use of oral analgesics and non-pharmacological strategies and the psychological well-being of older patients living in nursing homes; the relationships between pain and psychological well-being were also explored.
Background: Pain is common among older adults world-wide, and tends to be under-treated. Indeed, the high prevalence of pain may further hinder the fulfilment of psychological needs in a Maslow hierarchy of needs model.
Method: It was a quantitative cross-sectional study; older adults from six nursing homes were invited to join the study in 2007-2009, with a response rate of 100%. Pain was measured using the Geriatric Pain Assessment, happiness using the Subjective Happiness Scale, life satisfaction using the Life Satisfaction Index - A Form, loneliness using the Revised UCLA Loneliness Scale and depres…
matched on Homes for the Aged (mesh), Geriatric Assessment (mesh), older adults (text)
Ferrara MC, Pérez LM, Sole AR, Villa-García L, Ars J, Soto-Bagaria L, Bellelli G, Cesari M, Enfedaque MB, Inzitari M (2023)MEDLINE-indexed journal, not yet read by usJournal of internal medicine22 citations Sustained improvement of intrinsic capacity in community-dwelling older adults: The +AGIL Barcelona multidomain program.
Background: Different programs promote healthy ageing through the optimization of intrinsic capacity. However, a major challenge is to assess their sustained effects over time. +AGIL Barcelona, a consolidated multidomain program, aims to optimize older adults' intrinsic capacity through a coordinated approach among primary care, geriatrics and community resources, in agreement with the integrated care for older people (ICOPE) guidelines. We aimed to evaluate the +AGIL Barcelona longitudinal effect on older adults' physical performance.
Methods: All +AGIL Barcelona consecutive participants since 2016 were enrolled. After a comprehensive geriatric assessment, a tailored, multidisciplinary intervention aligned with the ICOPE guidelines is offered. It includes a 10-week boost multicomponent exercise program, nutritional and sleep-hygiene counselling, revision and optimization of pharmacologi…
matched on Frailty (mesh), Geriatric Assessment (mesh), healthy ageing (text), older adults (text)
Frailty Combined with Loneliness or Social Isolation: An Elevated Risk for Mortality in Later Life.
Background/objectives: Frailty, loneliness, and social isolation are all associated with adverse outcomes in older adults, but little is known about their combined impact on mortality.
Design: Prospective cohort study.
Setting: The Longitudinal Aging Study Amsterdam.
Participants: Community-dwelling older adults aged 65 and older (n = 1,427).
Measurements: Frailty was measured with the frailty phenotype (Fried criteria). Loneliness was assessed with the De Jong Gierveld Loneliness Scale. Social isolation was operationalized using information on partner status, social support, and network size. Two categorical variables were created, for each possible combination regarding frailty and loneliness (FL) and frailty and social isolation (FS), respectively. Mortality was monitored over a period of 22 years (1995-2017). Survival curves and Cox proportional hazard models were used to study the e…
matched on Frailty (mesh), Geriatric Assessment (mesh), later life (text), older adults (text)
Deprescribing in older people approaching end-of-life: development and validation of STOPPFrail version 2.
Background: Screening Tool of Older Persons Prescriptions in Frail adults with limited life expectancy (STOPPFrail) criteria were developed in 2017 to assist physicians with deprescribing decisions in older people approaching end-of-life. Updating was required to make the tool more practical, patient-centred and complete.
Methods: a thorough literature review was conducted to, first, devise a practical method for identifying older people who are likely to be approaching end-of-life, and second, reassess and update the existing deprescribing criteria. An eight-member panel with a wide-ranging experience in geriatric pharmacotherapy reviewed a new draft of STOPPFrail and were invited to propose new deprescribing criteria. STOPPFrail version 2 was then validated using Delphi consensus methodology.
Results: STOPPFrail version 2 emphasises the importance of shared decision-making in the depre…
matched on Frail Elderly (mesh), Frailty (keyword)
Determinants of limitations in activities of daily living among community-dwelling persons aged 80 years and older: Longitudinal national evidence from the Health, Aging and Retirement in Thailand study, 2015-2022.
Aim: Few studies have longitudinally assessed the determinants of limitations in activities of daily living (LADL) among persons aged ≥80 years. The aim of this study was to estimate the determinants of LADL among persons aged ≥80 years based on 4-wave national longitudinal data from Thailand.
Methods: Data from the Health, Aging and Retirement in Thailand study from 2015, 2017, 2020 and 2022 were utilized. The sample was restricted to community-dwelling persons aged ≥80 years (analytic sample: n = 3113 observations). For the pooled sample, the average age was 85.4 years (range 80-117 years). Established measurements were used to assess LADL. Linear fixed effects regression was applied to assess the time-varying determinants and outcomes.
Results: Linear fixed effects regressions showed that increasing age, an increase in the number of chronic conditions, an increase in depressive sympto…
matched on Aging (mesh), Geriatric Assessment (mesh)
Late-life intermittent fasting decreases aging-related frailty and increases renal hydrogen sulfide production in a sexually dimorphic manner.
Global average life expectancy continues to rise. As aging increases the likelihood of frailty, which encompasses metabolic, musculoskeletal, and cognitive deficits, there is a need for effective anti-aging treatments. It is well established in model organisms that dietary restriction (DR), such as caloric restriction or protein restriction, enhances health and lifespan. However, DR is not widely implemented in the clinic due to patient compliance and its lack of mechanistic underpinnings. Thus, the present study tested the effects of a somewhat more clinically applicable and adoptable DR regimen, every-other-day (EOD) intermittent fasting, on frailty in 20-month-old male and female C57BL/6 mice. Frailty was determined by a series of metabolic, musculoskeletal, and cognitive tasks performed prior to and toward the end of the 2.5-month dietary intervention. Late-life EOD fasting attenuate…
matched on Aging (mesh), Frailty (mesh)
Pagliai G, Sofi F, Dinu M, Sticchi E, Vannetti F, Molino Lova R, Ordovàs JM, Gori AM, Marcucci R, Giusti B, Macchi C (2019)MEDLINE-indexed journal, not yet read by usScientific reports15 citations CLOCK gene polymorphisms and quality of aging in a cohort of nonagenarians - The MUGELLO Study.
A total of 356 elderly subjects [257F; 88-106 years] were genotyped for three polymorphisms of the CLOCK gene by TaqMan real-time PCR approach, in order to find associations with quality of aging. Subjects homozygous for the minor allele of rs1801260 were less frequently overweight (p = 0.046), had higher fasting glucose levels (p = 0.037), better scores at the Clock Drawing Test (CDT) (p = 0.047) and worse scores at the Geriatric Depression Scale (p = 0.032). Subjects homozygous for the minor allele of rs11932595 showed higher fasting glucose levels (p = 0.044) and better scores at CDT (p = 0.030). Conversely, subjects homozygous for the minor allele of rs4580704 showed higher triglyceride (p = 0.012), and LDL-cholesterol levels (p = 0.44), and a greater adherence to the Mediterranean diet (MD) (p = 0.044). In addition, AAC, AAG, GGC and AGC (rs1801260-rs11932595-rs4580704) haplotypes w…
matched on Aging (mesh), Geriatric Assessment (mesh)
What matters for life satisfaction among the oldest-old? Evidence from China.
Objective: The world population is aging rapidly and the well-being of older people is of great interest. Therefore, this study investigates the determinants of life satisfaction among the oldest-old (i.e. individuals aged 80 or over) in China.
Materials and methods: We use the 2011/2012 Chinese Longitudinal Healthy Longevity Survey data (n = 6530) for this paper. Logistic regression is used to analyse the effects of socio-demographic, economic, health, instrumental activities of daily living, family and community factors on life satisfaction and depression among the oldest-old in China.
Results: Our analysis confirms the significance of many factors affecting life satisfaction among the oldest-old in China. Factors that are correlated with life satisfaction include respondent's sex, education, place of residence, self-rated health status, cognitive ability (using mini mental state exami…
matched on Aging (mesh), Geriatric Assessment (mesh)
Jeste DV, Savla GN, Thompson WK, Vahia IV, Glorioso DK, Martin AS, Palmer BW, Rock D, Golshan S, Kraemer HC, Depp CA (2013)MEDLINE-indexed journal, not yet read by usThe American journal of psychiatry298 citations Association between older age and more successful aging: critical role of resilience and depression.
Objective: There is growing public health interest in understanding and promoting successful aging. While there has been some exciting empirical work on objective measures of physical health, relatively little published research combines physical, cognitive, and psychological assessments in large, randomly selected, community-based samples to assess self-rated successful aging.
Method: In the Successful AGing Evaluation (SAGE) study, the authors used a structured multicohort design to assess successful aging in 1,006 community-dwelling adults in San Diego County, ages 50-99 years, with oversampling of people over 80. A modified version of random-digit dialing was used to recruit subjects. Evaluations included a 25-minute telephone interview followed by a comprehensive mail-in survey of physical, cognitive, and psychological domains, including positive psychological traits and self-rated …
matched on Aging (mesh), Geriatric Assessment (mesh)
Aida J, Kondo K, Kawachi I, Subramanian SV, Ichida Y, Hirai H, Kondo N, Osaka K, Sheiham A, Tsakos G, Watt RG (2013)MEDLINE-indexed journal, not yet read by usJournal of epidemiology and community health64 citations Does social capital affect the incidence of functional disability in older Japanese? A prospective population-based cohort study.
Background: Recent increases in numbers of older people have been accompanied by increases in those with functional disability. No study has examined the association between community social capital and the onset of functional disability.
Methods: The association between community social capital and the onset of functional disability was examined using data from the Aichi Gerontological Evaluation Study, a prospective cohort established in 2003 in Japan. Perceptions of community social capital (indicators of social cohesion such as trust of others and extent of social participation) in 6953 men and 7636 women aged 65 years or older were surveyed. Multilevel survival analysis using the discrete-time hazard model was applied.
Results: During 4-year follow-up, onset of functional disability occurred in 759 men and 1146 women. Women living in communities with higher mistrust had 1.68 (95% CI…
matched on Aging (mesh), Geriatric Assessment (mesh)
Telomere length and psychological well-being in patients with chronic heart failure.
Background: psychological stress and depressive symptoms have been implicated with accelerated ageing and increased progression of diseases. Shorter telomere length indicates a more advanced biological age. It is unknown whether psychological well-being is associated with telomere length in patients with the somatic condition of chronic heart failure (CHF).
Design: a cross-sectional analysis was used.
Setting: patients were admitted to the hospital with signs and symptoms of CHF.
Objective: the study aimed to assess the association between telomere length and psychological well-being in patients with CHF.
Methods: telomere length was determined by quantitative polymerase chain reaction in 890 patients with New York Heart Association functional class II to IV CHF. We evaluated the perceived mental health by the validated RAND-36 questionnaire. Depressive symptoms were assessed by the Cent…
matched on Aging (mesh), Geriatric Assessment (mesh)
Understanding advance care planning as a process of health behavior change.
Objectives: To explore whether models of health behavior change can help to inform interventions for advance care planning (ACP).
Design: Qualitative cross-sectional study.
Setting: Community.
Participants: Sixty-three community-dwelling persons aged 65 and older and 30 caregivers with experience as surrogate decision-makers.
Measurements: In focus groups conducted separately with older persons and caregivers, participants were asked to discuss ways they had planned for future declines in health and why they had or had not engaged in such planning. Transcripts were analyzed using grounded theory.
Results: Four themes illustrated the potential of applying models of health behavior change to improve ACP. (1) Participants demonstrated variable readiness to engage in ACP and could be in different stages of readiness for different components of ACP, including consideration of treatment goals,…
matched on Aging (mesh), Geriatric Assessment (mesh)
Lyyra TM, Heikkinen RL (2006)MEDLINE-indexed journal, not yet read by usThe journals of gerontology. Series B, Psychological sciences and social sciences128 citations Perceived social support and mortality in older people.
Objectives: This study examines the effect of perceived social support on all-cause mortality at a 10-year follow-up as well as the plausible mediating factors in this association.
Methods: We measured perceived social support in 206 Finnish men and women aged 80 years old by using the Social Provision Scale, which consists of six dimensions: attachment, social integration, opportunity for nurturance, reassurance of worth, reliable alliance, and guidance.
Results: By using a theoretical framework that divided perceived social support into assistance-related and non-assistance-related support, we found that the risk of death was almost 2.5 times higher in women in the lowest tertile of non-assistance-related social support (comprising infrequent experiences of reassurance of worth, emotional closeness, sense of belonging and opportunity for nurturance) than in women in the highest tertile…
matched on Aging (mesh), Geriatric Assessment (mesh)