Infertility and pregnancy loss

وَلَا يَزَالُ ٱلَّذِينَ كَفَرُواْ فِي مِرۡيَةࣲ مِّنۡهُ حَتَّىٰ تَأۡتِيَهُمُ ٱلسَّاعَةُ بَغۡتَةً أَوۡ يَأۡتِيَهُمۡ عَذَابُ يَوۡمٍ عَقِيمٍ

The disbelievers will remain in doubt about it until the Hour suddenly overpowers them or until torment descends on them on a Day devoid of all hope

أَوۡ يُزَوِّجُهُمۡ ذُكۡرَانࣰ ا وَإِنَٰثࣰ اۖ وَيَجۡعَلُ مَن يَشَآءُ عَقِيمًاۚ إِنَّهُۥ عَلِيمࣱ قَدِيرࣱ‏

male to whoever He will, or both male and female, and He makes whoever He will barren: He is all knowing and all powerful

فَأَقۡبَلَتِ ٱمۡرَأَتُهُۥ فِي صَرَّةࣲ فَصَكَّتۡ وَجۡهَهَا وَقَالَتۡ عَجُوزٌ عَقِيمࣱ‏

His wife then entered with a loud cry, struck her face, and said, ‘A barren old woman?’

وَفِي عَادٍ إِذۡ أَرۡسَلۡنَا عَلَيۡهِمُ ٱلرِّيحَ ٱلۡعَقِيمَ

There is another sign in the Ad: We sent the life-destroying wind against them

۞وَعِندَهُۥ مَفَاتِحُ ٱلۡغَيۡبِ لَا يَعۡلَمُهَآ إِلَّا هُوَۚ وَيَعۡلَمُ مَا فِي ٱلۡبَرِّ وَٱلۡبَحۡرِۚ وَمَا تَسۡقُطُ مِن وَرَقَةٍ إِلَّا يَعۡلَمُهَا وَلَا حَبَّةࣲ فِي ظُلُمَٰتِ ٱلۡأَرۡضِ وَلَا رَطۡبࣲ وَلَا يَابِسٍ إِلَّا فِي كِتَٰبࣲ مُّبِينࣲ‏

He has the keys to the unseen: no one knows them but Him. He knows all that is in the land and sea. No leaf falls without His knowledge, nor is there a single grain in the darkness of the earth, or anything, fresh or withered, that is not written in a clear Record

وَلَمَّا سُقِطَ فِيٓ أَيۡدِيهِمۡ وَرَأَوۡاْ أَنَّهُمۡ قَدۡ ضَلُّواْ قَالُواْ لَئِن لَّمۡ يَرۡحَمۡنَا رَبُّنَا وَيَغۡفِرۡ لَنَا لَنَكُونَنَّ مِنَ ٱلۡخَٰسِرِينَ

When, with much wringing of hands, they perceived that they were doing wrong, they said, ‘If our Lord does not have mercy and forgive us, we shall be the losers.’

And those who disbelieve will not cease to be in doubt of it that is the Qur’ān — because of what Satan had cast onto the tongue of the Prophet s and what had thereafter been nullified — until the Hour comes upon them unawares that is the Hour of their death or of resurrection comes upon them suddenly or there come upon them the chastisement of a day of desolation ‘aqīm namely the day of Badr which held nothing of good for disbelievers much like a sterile wind rīh ‘aqīm that bears no good; or it means the Day of Resurrection referred to as ‘desolate’ because thereafter there will be no more night.

Or He combines them that is to say or He makes them males and females; and He makes whomever He will infertile such that she is unable to conceive or he cannot have a child. Surely He is Knower of what He creates Powerful in bringing about whatever He will.

Then his wife Sarah came forward clamouring shouting fī sarratin is a circumstantial qualifier that is to say she came shouting and smote slapped her face and said ‘A barren old woman!’ who has never given birth to a child aged ninety-nine with Abraham being one hundred years old; or alternatively he was a hundred and twenty years old and she was ninety years old.

And those who disbelieved, will not cease to be in doubt about it until the Hour comes suddenly upon them, or there comes to them the torment of Yawm 'Aqim (55)The sovereignty on that Day will be that of Allah. He will judge between them. So those who believed and did righteous good deeds will be in Gardens of Delight (56)And those who disbelieved and denied Our Ayat, for them will be a humiliating torment (in Hell)(57) The Disbelievers will remain in Doubt and Confusion Allah tells us that the disbelievers will remain in doubt concerning this Qur'an. This was the view of Ibn Jurayj and was the view favored by Ibn Jarir. حَتَّىٰ تَأْتِيَهُمُ السَّاعَةُ بَغْتَةً (until the Hour comes suddenly upon them,) Mujahid said: "By surprise." Qatadah said: بَغْتَةً (suddenly) means, the command of Allah will catch the people unaware. Allah never seizes a people except when they are intoxicate

To Allah belongs the kingdom of the heavens and the earth. He creates what He wills. He bestows female upon whom He wills, and bestows male upon whom He wills (49)Or He bestows both males and females, and He renders barren whom He wills. Verily, He is the All-Knower and is Able (to do all things)(50) Allah tells us that He is the Creator, Sovereign and Controller of the heavens and the earth. Whatever he wills happens, and whatever He does not will does not happen. He gives to whomsoever He wills and withholds from whomsoever he wills; none can withhold what He gives, and none can give what He withholds, and He creates whatever He wills. يَهَبُ لِمَنْ يَشَاءُ إِنَاثًا (He bestows female upon whom He wills.) means, He gives them daughters only. Al-Baghawi said, "And among them (those who were given daughters only) was Lut, peace be upon him." وَيَهَبُ لِمَنْ يَشَاءُ الذُّكُورَ (and b

Has the story reached you, of the honored guests of Ibrahim (24)When they came in to him and said: "Salaman!" He answered: "Salamun" and said: "You are a people unknown to me. (25)Then he turned to his household, and brought out a roasted calf (26)And placed it before them (saying): "Will you not eat? (27)Then he conceived fear of them (when they ate not). They said: "Fear not." And they gave him glad tidings of a son having knowledge (28)Then his wife came forward with a loud voice; she smote her face, and said: "A barren old woman! (29)They said: "Even so says your Lord. Verily, He is the All-Wise, the All-Knower. (30) The Guests of the Prophet Ibrahim We mentioned this story before in Surah Hud and Al-Hijr. Allah said, هَلْ أَتَاكَ حَدِيثُ ضَيْفِ إِبْرَاهِيمَ الْمُكْرَمِينَ (Has the story reached you, of the honored guests of Ibrahim), whom Ibrahim honored and who, فَقَالُوا سَلَ

حَدَّثَنَا مَحْمُودُ بْنُ غَيْلاَنَ، حَدَّثَنَا أَبُو أَحْمَدَ الزُّبَيْرِيُّ، حَدَّثَنَا سُفْيَانُ، عَنِ الأَعْمَشِ، عَنْ عُمَارَةَ بْنِ عُمَيْرٍ، عَنْ عَبْدِ الرَّحْمَنِ بْنِ يَزِيدَ، عَنْ عَبْدِ اللَّهِ بْنِ مَسْعُودٍ، قَالَ خَرَجْنَا مَعَ النَّبِيِّ صلى الله عليه وسلم وَنَحْنُ شَبَابٌ لاَ نَقْدِرُ عَلَى شَيْءٍ فَقَالَ ‏ "‏ يَا مَعْشَرَ الشَّبَابِ عَلَيْكُمْ بِالْبَاءَةِ فَإِنَّهُ أَغَضُّ لِلْبَصَرِ وَأَحْصَنُ لِلْفَرْجِ فَمَنْ لَمْ يَسْتَطِعْ مِنْكُمُ الْبَاءَةَ فَعَلَيْهِ بِالصَّوْمِ فَإِنَّ الصَّوْمَ لَهُ وِجَاءٌ ‏"‏ ‏.‏ قَالَ أَبُو عِيسَى هَذَا حَدِيثٌ حَسَنٌ صَحِيحٌ ‏.‏ حَدَّثَنَا الْحَسَنُ بْنُ عَلِيٍّ الْخَلاَّلُ، حَدَّثَنَا عَبْدُ اللَّهِ بْنُ نُمَيْرٍ، حَدَّثَنَا الأَعْمَشُ، عَنْ عُمَارَةَ، نَحْوَهُ ‏.‏ قَالَ أَبُو عِيسَى وَقَدْ رَوَى غَيْرُ، وَاحِدٍ، عَنِ الأَعْمَشِ، بِهَذَا الإِسْنَادِ مِثْلَ هَذَا ‏.‏ وَرَوَى أَبُو مُعَاوِيَةَ، وَالْمُحَارِبِيُّ، عَنِ الأَعْمَشِ، عَنْ إِبْرَاهِيمَ، عَنْ عَلْقَمَةَ، عَنْ عَبْدِ اللَّهِ، عَنِ النَّبِيِّ صلى الله عليه وسلم نَحْوَهُ ‏.‏ قَالَ أَبُو عِيسَى كِلاَهُمَا صَحِيحٌ ‏.‏

Abdullah bin Mas'ud narrated:"We went with Allah's Messenger, while we were young men who had nothing. He said: 'O young men! You should marry, for indeed it helps in lowering the gaze and protecting the private parts. Whoever among you is not able to marry, then let him fast, for indeed fasting will diminish his sexual desire

حَدَّثَنَا أَبُو هِشَامٍ الرِّفَاعِيُّ، وَزَيْدُ بْنُ أَخْزَمَ الطَّائِيُّ، وَإِسْحَاقُ بْنُ إِبْرَاهِيمَ الْبَصْرِيُّ، قَالُوا حَدَّثَنَا مُعَاذُ بْنُ هِشَامٍ، عَنْ أَبِيهِ، عَنْ قَتَادَةَ، عَنِ الْحَسَنِ، عَنْ سَمُرَةَ، أَنَّ النَّبِيَّ صلى الله عليه وسلم نَهَى عَنِ التَّبَتُّلِ ‏.‏ قَالَ أَبُو عِيسَى وَزَادَ زَيْدُ بْنُ أَخْزَمَ فِي حَدِيثِهِ وَقَرَأَ قَتَادَةُ ‏:‏ ‏(‏ولقدْ أَرْسَلْنا رُسُلاً مِنْ قَبْلِكَ وَجَعَلْنَا لَهُمْ أَزْوَاجًا وَذُرِّيَّةً ‏)‏ ‏.‏ قَالَ وَفِي الْبَابِ عَنْ سَعْدٍ وَأَنَسِ بْنِ مَالِكٍ وَعَائِشَةَ وَابْنِ عَبَّاسٍ ‏.‏ قَالَ أَبُو عِيسَى حَدِيثُ سَمُرَةَ حَدِيثٌ حَسَنٌ غَرِيبٌ ‏.‏ وَرَوَى الأَشْعَثُ بْنُ عَبْدِ الْمَلِكِ هَذَا الْحَدِيثَ عَنِ الْحَسَنِ عَنْ سَعْدِ بْنِ هِشَامٍ عَنْ عَائِشَةَ عَنِ النَّبِيِّ صلى الله عليه وسلم نَحْوَهُ ‏.‏ وَيُقَالُ كِلاَ الْحَدِيثَيْنِ صَحِيحٌ ‏.‏

Qatadah narrated from Al-Hasan, from Samurah that:The Prophet prohibited celibacy

وَحَدَّثَنَاهُ قُتَيْبَةُ بْنُ سَعِيدٍ، حَدَّثَنَا عَبْدُ الْعَزِيزِ يَعْنِي الدَّرَاوَرْدِيَّ، ح وَحَدَّثَنَا أَبُو بَكْرِ بْنُ أَبِي شَيْبَةَ حَدَّثَنَا خَالِدُ بْنُ مَخْلَدٍ، حَدَّثَنَا سُلَيْمَانُ بْنُ بِلاَلٍ، جَمِيعًا بِهَذَا الإِسْنَادِ ‏.‏

This hadith has been narrated by Sulaiman b. Bilal with the same chain of transmitters

وَحَدَّثَنَا أَبُو بَكْرٍ، وَعُثْمَانُ، ابْنَا أَبِي شَيْبَةَ ح وَحَدَّثَنِي عَمْرٌو النَّاقِدُ، قَالُوا جَمِيعًا حَدَّثَنَا أَبُو خَالِدٍ الأَحْمَرُ، عَنْ يَزِيدَ بْنِ كَيْسَانَ، عَنْ أَبِي حَازِمٍ، عَنْ أَبِي هُرَيْرَةَ، قَالَ قَالَ رَسُولُ اللَّهِ صلى الله عليه وسلم ‏ "‏ لَقِّنُوا مَوْتَاكُمْ لاَ إِلَهَ إِلاَّ اللَّهُ ‏"‏ ‏.‏

Abu Huraira reported Allah's Messenger (ﷺ) as saying:Exhort to recite" There is no god but Allah" to those of you who are dying

حَدَّثَنَا أَبُو بِشْرٍ، بَكْرُ بْنُ خَلَفٍ وَمُحَمَّدُ بْنُ بَشَّارٍ قَالاَ حَدَّثَنَا يَحْيَى بْنُ سَعِيدٍ، حَدَّثَنَا عَبْدُ الْحَمِيدِ بْنُ جَعْفَرٍ، عَنْ أَبِيهِ، عَنْ حَكِيمِ بْنِ أَفْلَحَ، عَنْ أَبِي مَسْعُودٍ، عَنِ النَّبِيِّ ـ صلى الله عليه وسلم ـ قَالَ ‏ "‏ لِلْمُسْلِمِ عَلَى الْمُسْلِمِ أَرْبَعُ خِلاَلٍ يُشَمِّتُهُ إِذَا عَطَسَ وَيُجِيبُهُ إِذَا دَعَاهُ وَيَشْهَدُهُ إِذَا مَاتَ وَيَعُودُهُ إِذَا مَرِضَ ‏"‏ ‏.‏

It was narrated from Abu Mas’ud that the Prophet (ﷺ) said:“The Muslim has four things due from the Muslim: He should answer [by saying Yarhamuk-Allah (may Allah have mercy on you)] to him if he sneezes (and says Al-Hamdulillah); he should accept his invitation if he invites him; he should attend his funeral if he dies; and he should visit him if he falls sick.”

حَدَّثَنَا أَبُو بَكْرِ بْنُ أَبِي شَيْبَةَ، حَدَّثَنَا مُحَمَّدُ بْنُ بِشْرٍ، عَنْ مُحَمَّدِ بْنِ عَمْرٍو، عَنْ أَبِي سَلَمَةَ، عَنْ أَبِي هُرَيْرَةَ، قَالَ قَالَ رَسُولُ اللَّهِ ـ صلى الله عليه وسلم ـ ‏ "‏ خَمْسٌ مِنْ حَقِّ الْمُسْلِمِ عَلَى الْمُسْلِمِ رَدُّ التَّحِيَّةِ وَإِجَابَةُ الدَّعْوَةِ وَشُهُودُ الْجِنَازَةِ وَعِيَادَةُ الْمَرِيضِ وَتَشْمِيتُ الْعَاطِسِ إِذَا حَمِدَ اللَّهَ ‏"‏ ‏.‏

It was narrated from Abu Hurairah that the Messenger of Allah (ﷺ) said:“Five are the rights of the Muslim: Returning his greeting, accepting his invitation; attending his funeral; visiting the sick; and answering (saying Yarhamuk-Allah) to the one who sneezes, if he praises Allah (says Al-Hamdu Lillah).”

وقال سري السقطى : من ادعى باطن علم ينقضه ظاهر حكم فهو غالط

وقال بشر ما سألت أحدا قط شيئا إلا سريا السقطى لأنه قد صح عندي زهده في الدنيا فهو يفرح بخروج الشيء من يده ويتبرم ببقائه عنده فأكون عونا له على ما يحب

وقال سرى السقطي رحمه الله آه على لقمة ليس على الله فيها تبعة ولا لمخلوق فيها منة

فيكره ذلك والسقط ينبغي أن يسمى

وكان سرى السقطي يقول للصوفية إذا خرج الشتاء فقد خرج أذار وأورقت الأشجار وطاب الإنتشار فانتشروا

وقال السري السقطي: إنى لأنظر كل يوم إلى أنفى مخافة أن يكون قد اسود وجهي.

A randomized clinical trial to determine optimal infertility treatment in older couples: the Forty and Over Treatment Trial (FORT-T).: Objective: To determine the optimal infertility therapy for women at the end of their reproductive potential. Design: Randomized clinical trial. Setting: Academic medical centers and private infertility center in a state with mandated insurance coverage. Patient(s): Couples with ≥ 6 months of unexplained infertility; female partner aged 38-42 years. Intervention(s): Randomized to treatment with two cycles of clomiphene citrate (CC) and intrauterine insemination (IUI), follicle stimulating hormon

The clinical effectiveness of the Mind/Body Program for Infertility on wellbeing and assisted reproduction outcomes: a randomized controlled trial in search for active ingredients.: Study question: Does the Mind/Body Program for Infertility (MBPI) perform better, due to certain distinctive elements, than a partly matched support group in improving the wellbeing and medically assisted reproduction (MAR) outcomes of women with elevated distress levels in a clinical setting? Summary answer: While robust enhancements occurred in the wellbeing overall, the cognitive behavioural and formalized stress management elements of the MBPI allowed a significantly stronger improvement in

Men's grief following pregnancy loss and neonatal loss: a systematic review and emerging theoretical model.: Background: Emotional distress following pregnancy loss and neonatal loss is common, with enduring grief occurring for many parents. However, little is known about men's grief, since the majority of existing literature and subsequent bereavement care guidelines have focused on women. To develop a comprehensive understanding of men's grief, this systematic review sought to summarise and appraise the literature focusing on men's grief following pregnancy loss and neonatal loss. Methods: A systemat

The effects of psychosocial interventions on the mental health, pregnancy rates, and marital function of infertile couples undergoing in vitro fertilization: a systematic review.: Purpose: The purpose of this study was to examine the effects of psychosocial interventions on the mental health, pregnancy rates, and marital function of infertile couples undergoing in vitro fertilization (IVF), as determined through RCT studies. Methods: Using the electronic databases PubMed, EMBase, Cochrane Library, CINAHL, PsycInfo, and CAJ, a systematic literature search was conducted in July 2015. MeSH terms, key words, and free words such as "infertility," "fertilization in vitro," "psy

Stress, distress and outcome of assisted reproductive technology (ART): a meta-analysis.: Background: A number of studies have investigated the relationship between psychological factors such as stress and distress (measured as anxiety and depression) and outcomes of assisted reproductive technology (ART). The results, however, are inconsistent, and the strength of any associations remains to be clarified. We conducted a systematic review and meta-analysis of the results of studies reporting on the associations between stress, anxiety, and depression and ART outcomes. Methods: Prospe

The impact of occupational shift work and working hours during pregnancy on health outcomes: a systematic review and meta-analysis.: Backgroud: An increasing number of original studies suggest that exposure to shift work and long working hours during pregnancy could be associated with the risk of adverse pregnancy outcomes, but the results remain conflicting and inconclusive. Objective: To examine the influences of shift work and longer working hours during pregnancy on maternal and fetal health outcomes. Data sources: Five electronic databases and 3 gray literature sources were searched up to March 15, 2019. Methods of study

Silent loss and the clinical encounter: Parents' and physicians' experiences of stillbirth-a qualitative analysis.

Background: In the United States, an estimated 70 stillbirths occur each day, on average 25,000 each year. Research into the prevalence and causes of stillbirth is ongoing, but meanwhile, many parents suffer this devastating loss, largely in silence, due to persistent stigma and taboo; and many health providers report feeling ill equipped to support grieving parents. Interventions to address bereavement after neonatal death are increasingly common in U.S. hospitals, and there is growing data on the nature of parent bereavement after a stillbirth. However, further research is needed to evaluate supportive interventions and to investigate the parent-clinician encounter during hospitalization following a stillbirth. Qualitative inquiry offers opportunities to better understand the lived experience of parents against the backdrop of clinicians' beliefs, intentions, and well-meaning efforts t…

matched on Stillbirth (mesh)

Occupational exposures among nurses and risk of spontaneous abortion.

Objective: We investigated self-reported occupational exposure to antineoplastic drugs, anesthetic gases, antiviral drugs, sterilizing agents (disinfectants), and X-rays and the risk of spontaneous abortion in US nurses. Study design: Pregnancy outcome and occupational exposures were collected retrospectively from 8461 participants of the Nurses' Health Study II. Of these, 7482 were eligible for analysis using logistic regression. Results: Participants reported 6707 live births, and 775 (10%) spontaneous abortions (<20 weeks). After adjusting for age, parity, shift work, and hours worked, antineoplastic drug exposure was associated with a 2-fold increased risk of spontaneous abortion, particularly with early spontaneous abortion before the 12th week, and 3.5-fold increased risk among nulliparous women. Exposure to sterilizing agents was associated with a 2-fold increased risk of late spo…

matched on Abortion, Spontaneous (mesh)

The unique experiences of women and their families after the death of a baby.

This study sought to discover the ways in which the woman's experience of a baby's death affects her as an individual and within the family system. More specifically, this study asked: Does a woman's experience of stillbirth appear to have long-lasting effects, and what variables influence such changes? Expressed through their own narratives, it appears that a baby's death has long-lasting effects for a woman. Variables that affect her perceptual experience include social support, legitimization of her loss, opportunities for rituals, and existential emotions such as shame and guilt. Results revealed that enhanced understanding of the experience and psychosocial support may help some women and their family systems cope with the long-term effects of this loss.

matched on Stillbirth (mesh)

How physicians cope with stillbirth or neonatal death: a national survey of obstetricians.

Objective: To identify U.S. obstetricians' experiences and attitudes about perinatal death, their coping strategies, and their beliefs about the adequacy of their training on this topic. Methods: A total of 1,500 randomly selected U.S. obstetricians were mailed a self-administered survey about their experiences and attitudes in dealing with perinatal death. Physicians received up to three copies of the survey, a reminder card, and a $2 cash incentive. Eight hundred four physicians (54%) completed the entire survey. Results: Seventy-five percent of respondents reported that caring for a patient with a stillbirth took a large emotional toll on them personally, and nearly one in 10 obstetricians reported they had considered giving up obstetric practice because of the emotional difficulty in caring for a patient with a stillbirth. Talking informally with colleagues (87%) or friends and famil…

matched on Stillbirth (mesh)

Stillbirth: the mother's experience and implications for improving care.

More children die as a result of stillbirth than all other causes of infant deaths combined (Ananth, Shiliang, Kinzler, and Kramer, 2005; Goldenberg, Kirby, and Culhane, 2004; Froen, 2005; National Institute of Health, 2004); yet, mothers experiencing stillbirth are often left without support afterwards (Kubler-Ross, 2004; Fahey-McCarthy, 2003; Fletcher 2002; Saddler, 1987; DeFrain, 1986; Kirkley-Best & Kellner, 1982). Despite social work's growing involvement in care at the end of life, parents of stillborn children have not experienced consistent, relevant, and competent professional care in coping with the tragedy of death. Forty-seven women between the ages of 19 and 51 were recruited through nonprofit agencies that provide bereavement care to grieving families. Results of this qualitative study suggest that stillbirth is emotionally complex with long-lasting symptoms of grief and si…

matched on Stillbirth (mesh)

Measuring EQ-5D-5L utility values in parents who have experienced perinatal death.

Background: Policymakers use clinical and cost-effectiveness evidence to support decisions about health service commissioning. In England, the National Institute for Health and Care Excellence (NICE) recommend that in cost-effectiveness analyses "effectiveness" is measured as quality-adjusted life years (QALYs), derived from health utility values. The impact of perinatal death (stillbirth/neonatal death) on parents' health utility is currently unknown. This knowledge would improve the robustness of cost-effectiveness evidence for policymakers. Objective: This study aimed to estimate the impact of perinatal death on parents' health utility. Methods: An online survey conducted with mothers and fathers in England who experienced a perinatal death. Participants reported how long ago their baby died and whether they/their partner subsequently became pregnant again. They were asked to rate the…

matched on Stillbirth (keyword), Perinatal Death (mesh)

Existential distress and meaning making among female breast cancer patients with cancer-related fertility concerns.

Objectives: The current study explored the impact of cancer-related fertility concerns on existential distress and meaning making among female breast cancer (BC) patients of childbearing age and assessed support needs. Methods: The current study was embedded within a larger study. A seven-question online survey was administered to female BC participants to explore meaning and identity in their lives. Applied thematic analysis was used to analyze participants' written responses. Results: A total of 98 participants completed the survey, the majority of whom identified as white, married or partnered, and employed full time and with stage I or II BC. More than 50% of the participants expressed a need for support from a counselor or support group during their cancer experience. Three subthemes emerged related to existential distress and cancer-related fertility concerns: (1) loss of womanhood…

matched on Infertility (keyword), infertility (text), Fertility (keyword)

Embryologist agreement when assessing blastocyst implantation probability: is data-driven prediction the solution to embryo assessment subjectivity?

Study question: What is the accuracy and agreement of embryologists when assessing the implantation probability of blastocysts using time-lapse imaging (TLI), and can it be improved with a data-driven algorithm? Summary answer: The overall interobserver agreement of a large panel of embryologists was moderate and prediction accuracy was modest, while the purpose-built artificial intelligence model generally resulted in higher performance metrics. What is known already: Previous studies have demonstrated significant interobserver variability amongst embryologists when assessing embryo quality. However, data concerning embryologists' ability to predict implantation probability using TLI is still lacking. Emerging technologies based on data-driven tools have shown great promise for improving embryo selection and predicting clinical outcomes. Study design, size, duration: TLI video files of …

matched on Fertilization in Vitro (mesh), infertility (text)

Experience of undergraduate midwifery students faced with perinatal death in clinical practice: A qualitative study.

Background: Student midwives often encounter perinatal loss including stillbirth and neonatal death as part of their clinical training. There has been limited research on how student midwives cope with perinatal death. Objective: To explore the experiences of undergraduate midwifery students facing perinatal death during their internships. Design: Qualitative research design based on interpretive phenomenological approach and COREQ-guided reporting. Setting: Tertiary maternal and child care center or general hospital. Participants: Undergraduate midwifery students from a medical university in Guangzhou, China. Methods: Study participants were recruited through purposive sampling. Semi-structured in-depth interviews were conducted between October 2020 and March 2021 with 12 midwifery students. Transcripts of the interviews were analyzed using Diekelmann's interpretive method. Results: Fou…

matched on Stillbirth (keyword), Perinatal Death (mesh)

Men's knowledge of their own fertility: a population-based survey examining the awareness of factors that are associated with male infertility.

Study question: How knowledgeable are men about the medical, environmental and psychological factors that are associated with male infertility? Summary answer: Men, across most demographic groups, have limited knowledge of the various factors that are associated with male infertility. What is known already: Few surveys have focused on men's knowledge of their own fertility. Studies of both men and women have found that men are comparatively less knowledgeable about issues of fertility and reproductive health. Study design, size, duration: A regionally representative sample of Canadian men completed a web-based survey of male fertility and reproductive health, over a 2-month period in 2015. Participants/materials, setting, methods: Men, aged 18-50 years, were recruited for the study. There were 701 male participants, with a mean age of 34.1 years. Each participant was asked to identify fa…

matched on Fertility (mesh), Infertility, Male (mesh), infertility (text)

Motherhood in childhood: addressing reproductive health hazards among adolescent married women in India.

Background: In India, due to the high prevalence of child marriage, most adolescent pregnancies occur within marriage. Pregnancy and childbirth complications are among the leading causes of death in girls aged 15 to 19 years. Hence, adolescent pregnancy is a serious health threat to young women in India. Methods: The study focuses on the level and trends of adolescent pregnancy rate (per thousand currently married adolescent women) in India in the last two decades, based on cross-sectional data from three different periods, DLHS-1 (1998-99), DLHS-2 (2002-04) and DLHS-3 (2007-08). Further, the determinants of adolescent pregnancy and its effects are analyzed using the DLHS-3 data, which used a multi-stage stratified systematic sampling design. The sample size of this study was 18,709 pregnancies that occurred to 14,006 currently married adolescent (15-19 years) women. Chi-square tests and…

matched on Stillbirth (keyword), Pregnancy Rate (mesh)

Fertility as a priority among at-risk adolescent males newly diagnosed with cancer and their parents.

Purpose: Infertility is a frequent consequence of cancer therapy and is often associated with psychological distress. Although adult survivors prioritize fertility and parenthood, this issue remains unexplored among adolescent males. This study examined future fertility as a priority (relative to other life goals) at time of diagnosis for at-risk adolescents and their parents. Methods: Newly diagnosed adolescent males (n = 96; age = 13.0-21.9 years) at increased risk for infertility secondary to cancer treatment prioritized eight life goals: to have school/work success, children, friends, wealth, health, a nice home, faith, and a romantic relationship. Patients' parents (fathers, n = 30; mothers, n = 61) rank-ordered the same priorities for their children. Results: "Having children" was ranked as a "top 3" life goal among 43.8 % of adolescents, 36.7 % of fathers, and 21.3 % of mothers. F…

matched on Fertility (mesh), Infertility, Male (mesh), infertility (text)

Patient-centred quality of care in an IVF programme evaluated by men and women.

Study question: Do men and women value the same aspects of quality of care during IVF treatment when measuring rates of importance by the validated instrument, quality from the patient's perspective of in vitro fertilization (QPP-IVF)? Summary answer: Women valued most aspects of care as significantly more important than their partner although men and women evaluated the importance of the different care factors in a similar pattern. What is known already: A few validated tools measuring patient-centred quality of care during IVF have been developed. Few studies of gender differences concerning experiences of patient-centred quality of care have been reported in the literature to date. Study design, size and duration: A two-centre study was conducted between September 2011 and May 2012. Heterosexual couples (n = 497) undergoing IVF were invited to complete a questionnaire before receiving…

matched on Fertilization in Vitro (mesh), infertility (text)

Specialized Versus Standard Care After Pregnancy and Neonatal Loss: A Cohort Study.

Pregnancy loss is a traumatic experience, and the quality of care can vary significantly across healthcare settings. However, evidence on the impact of different types of care on psychological outcomes is limited. This study examined the relationship between specialized care for parents experiencing pregnancy or neonatal loss and the level of Prolonged Grief Disorder (PGD) and Post-Traumatic Stress Disorder (PTSD) symptoms, as well as the role of midwifery support, one month post-loss. Using longitudinal data from 732 Danish parents who experienced a loss between 2016 and 2021, we found that 22.5% (n = 165) received specialized care. Compared to standard care, specialized care was associated with fewer PGD and PTSD symptoms. Additionally, parents who received specialized care reported significantly higher levels of midwifery support, with variation by type of loss (miscarriage/terminatio…

matched on Stillbirth (keyword), pregnancy loss (text)

Men's Experiences With Perinatal Loss: An Integrative Review.

Introduction: Perinatal loss is a tremendous loss for many and can have consequences that affect physical and mental health. This topic has been substantially examined among women; however, men's experiences with perinatal loss have lacked attention. Many men report significant grief, self-blame, stigma, loss of self-identity, lack of recognition of their loss, marginalization, and gendered expectations that negate their grieving process. This places men at risk for complicated or disenfranchised grief. Most studies examining perinatal loss have been conducted in countries outside of the United States and outside of the discipline of nursing. As nurses are concerned about holistic care of men and women, the findings resulting from studies with women and other cultural perspectives may not be generalizable to men in the United States. Purpose: The purpose of this integrative review was to…

matched on Stillbirth (keyword), miscarriage (text)

The Integration of the Resolved Through Sharing Perinatal Bereavement Follow-up Model with Latinx Cultural Values: A Case Illustration.

The Resolved Through Sharing (RTS) Perinatal bereavement model is an approach used for working with birthing people and their families who have experienced a perinatal loss. RTS is designed to help families cope with their grief and integrate the loss in their lives, meet the needs of the families during the initial crisis, and offer comprehensive care to each member of the family affected by the loss. This paper utilizes a case illustration to describe a year-long bereavement follow-up of an undocumented underinsured Latina woman who suffered a stillbirth during the beginning of the COVID-19 pandemic and the hostile anti-immigrant policy during the Trump presidency. The case illustration is based on a composite case of several Latina women who had pregnancy losses with similar outcomes, demonstrating how a perinatal palliative care (PPC) social worker provided ongoing bereavement suppor…

matched on Stillbirth (keyword), pregnancy loss (text)

Validation of a Brief Measure for Complicated Grief Specific to Reproductive Loss.

Objective Complicated grief reactions follow some pregnancy outcomes, like miscarriage, stillbirth, neonatal death, infant death, selective reduction, or termination of pregnancy. Stigma can delay treatment and worsen outcomes. Screening tools such as the Edinburgh Postnatal Depression Scale detect complicated grief poorly, and specific tools for prolonged or complicated grief after a reproductive loss are cumbersome. In this study, a five-item questionnaire to detect complicated grief after reproductive loss of any type was designed and preliminary validated. Methods A questionnaire patterned after the extensively validated Brief Grief Questionnaire (BGQ) was created by a group of physicians and lay advocates to employ non-traumatic but specific language related to grief after miscarriage, stillbirth, neonatal death, infant death, selective reduction, or termination of pregnancy. One hu…

matched on Stillbirth (keyword), miscarriage (text)

"There's no time limit on grief:" Women's perspectives on a novel reproductive grief screening tool.

Objective: Women who have experienced reproductive loss (i.e., miscarriage, stillbirth, abortion) evaluated the usefulness of a novel screening tool, Reproductive Grief Screen (RGS), to identify patients struggling with ongoing, complicated grief. Methods: This mixed-methods study involved U.S. women who had experienced reproductive loss. Online data collection resulted in 27 interviews and 282 surveys completed. Perceptions of and preferences about RGS were thematically analyzed. Chi square analyses assessed relationships between demographics and tool preferences. Results: RGS validated women's experiences with grief after reproductive loss. Women noted their providers may be unaware of their loss(es). Participants requested periodic screening using RGS beginning shortly after a loss (or during new patient intake) and occurring regularly (e.g., annually). Overall, women preferred comple…

matched on Stillbirth (keyword), miscarriage (text)

Bereavement Care Practices Following Stillbirths: Health-Care Provider's Perspective.

Background: Addressing stillbirth is a difficult task and becomes more challenging with a huge burden and skewed doctorpatient ratio. There is a lack of data regarding the knowledge about the bereavement care practices following pregnancy loss and practices being followed by the health-care providers in the Indian context. The objective of this study is to describe the experience, views, and practices of health-care professionals while managing women with stillbirths. Design: Internet-based Monkey Survey. Methodology: An on-line self completion questionnaire was shared with various health care providers via emails and whats app groups. Results: A total of 281 responses of health-care providers were analyzed, and the majority of them were obstetricians. Almost 90% had managed women with stillbirth, but just a third (38.1%) had provided bereavement care. The majority of them felt the lack …

matched on Stillbirth (keyword), pregnancy loss (text)

The Impact of the COVID-19 Pandemic on Perinatal Loss Experienced by the Parental Couple: Protocol for a Mixed Methods Study.

Background: At the beginning of 2020, mothers and fathers who experienced perinatal events (from conception to pregnancy and postpartum period) found themselves facing problems related to the emergency caused by the COVID-19 pandemic and the associated difficulties for health care centers in providing care. In the unexpected and negative event of perinatal loss (ie, miscarriage, stillbirth, and neonatal death) more complications occurred. Perinatal loss is a painful and traumatic life experience that causes grief and can cause affective disorders in the parental couple-the baby dies and the couple's plans for a family are abruptly interrupted. During the COVID-19 pandemic, limited access to perinatal bereavement care, due to the lockdown measures imposed on medical health care centers and the social distancing rules to prevent contagion, was an additional risk factor for parental mental …

matched on Stillbirth (keyword), miscarriage (text)

The Effect of Brief Supportive Psychotherapy on Prevention of Psychiatric Morbidity in Women with Miscarriage: A Randomized Controlled Trial about the First 24-hours of Hospitalization.

Objectives: Miscarriage is a common pregnancy complication causing substantial psychiatric complications. This study was designed to investigate whether the administration of brief supportive psychotherapy (BSP) is effective on the management of women with miscarriage when conducted in the first 24 hours of hospitalization in order to prevent symptoms of anxiety, depression, and grief at four-months post-miscarriage. Methods: We conducted a randomized clinical trial on 79 women with miscarriage hospitalized in Ayatollah Rohani teaching hospital. The women were randomly assigned into two groups (39 in the experimental group and 40 in the control group). All interventions were implemented for two study groups during the first 24 hours of hospitalization in a private room in the hospital. The experimental group received a two-hour BSP. The objective outcomes were assessed using Hospital Anx…

matched on Abortion, Spontaneous (keyword), miscarriage (text)

Gonadal function, fertility, and reproductive medicine in childhood and adolescent cancer patients: a national survey of Japanese pediatric endocrinologists.

An increasing number of pediatric cancer patients survive, and treatment-related infertility represents one of the most important issues for these patients. While official guidelines in Japan recommend long-term follow-up of childhood cancer survivors (CCSs), their gonadal function and fertility have not been clarified. To address this issue, we organized a working panel to compile evidence from long-term survivors who received treatments for cancer during childhood or adolescence. In collaboration with members of the CCS Committee of the Japanese Society for Pediatric Endocrinology (JSPE), we conducted a questionnaire survey regarding reproductive function in pediatric cancer patients. A cross-sectional survey was sent to 178 JSPE-certified councilors who were asked to self-evaluate the medical examinations they had performed. A total of 151 responses were obtained, revealing that 143 e…

matched on miscarriage (text), infertility (text), Fertility (keyword)

'WTF Uterus?' Metaphors of the Body as Positioning in Infertility Blogs by Muslim Women.

This paper uses a small-stories positioning framework to analyse metaphors of the body and related claims of identity in Muslim women's infertility blogs. I first conduct a directed qualitative content analysis to identify metaphorically used words and group them into a small set of metaphor families; I then apply Metaphor-Led Positioning Analysis to interpret how those metaphors position narrators, audiences, and institutions across small stories. I examine how narrators construct gendered selves in context - alternately contesting or adopting positions of victimhood - vis-à-vis hegemonic medical, social, and religious Discourses and key interlocutors (partners, families, clinicians, peers). Focusing on figurative language (e.g., the body as defective machine, battleground, empty container, rebellious agent, or season/journey), The article shows how metaphors mediate alignment with audi…

matched on Infertility (keyword), infertility (text)

Excessive Vitamin E Supplementation: Implications for Ovarian Physiology and Reproductive Health.

Infertility, a major global health problem affecting ~17.5% of couples, is influenced by various intrinsic (e.g., individual genetics) and extrinsic (e.g., related to environmental stimuli) factors. Oxidative stress and reactive oxygen species (ROS) are at the crossroads of these different stimulus-response pathways for both male and female gametes. While ROS are essential for ovarian processes such as folliculogenesis and oocyte maturation, changes in the ovarian ROS generation/recycling equilibrium can lead to impaired reproductive outcomes. Against this backdrop, noninvasive therapeutic approaches aimed at supplementing antioxidant (AO) molecules have emerged to correct prooxidant imbalances encountered in various stress situations. Numerous molecules have been tested, alone or in combination, for their beneficial effects on reproductive success in both men and women. The aim of this …

matched on Infertility (keyword), infertility (text)

Human endometrium-derived mesenchymal stem/stromal cells application in endometrial-factor induced infertility.

Endometrial-factor induced infertility remains one of the most significant pathology among all fertility disorders. Stem cell-based therapy is considered to be the next-generation approach. However, there are still issues about successfully retrieving human endometrium-derived mesenchymal stem/stromal cells (hEnMSCs). Moreover, we need to establish a better understanding of the effect of hEnMSCs on the endometrial recovery and the clinical outcome. According to these challenges we created a multi-step study. Endometrium samples were collected from females undergoing assisted reproductive technology (ART) procedure due to couple infertility. These samples were obtained using an endometrium scratching. The hEnMSCs were isolated from endometrium samples and characterized with flow cytometry analysis. Groups of endometrium injured female mice were established by the mechanical injury to uter…

matched on Infertility (keyword), infertility (text)