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Obsessions and compulsions

Intrusive thought and the rituals that answer it, including waswasa.

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Qurʾān

القرآن6 shown

Verses named for this subject by hand come first. The rest are found by the subject’s own Arabic and English senses and are shown as lexical matches, not as anchors anyone has confirmed.

Qur'ān 114:4English sense: whisperings | Arabic sense: الوسواس, وسواس

مِن شَرِّ ٱلۡوَسۡوَاسِ ٱلۡخَنَّاسِ

against the harm of the slinking whisperer––

Qur'ān 19:98English sense: whisperings

وَكَمۡ أَهۡلَكۡنَا قَبۡلَهُم مِّن قَرۡنٍ هَلۡ تُحِسُّ مِنۡهُم مِّنۡ أَحَدٍ أَوۡ تَسۡمَعُ لَهُمۡ رِكۡزَۢا

How many generations We have destroyed before them! Do you perceive a single one of them now, or hear as much as a whisper

Qur'ān 20:108English sense: whisperings

يَوۡمَئِذࣲ يَتَّبِعُونَ ٱلدَّاعِيَ لَا عِوَجَ لَهُۥۖ وَخَشَعَتِ ٱلۡأَصۡوَاتُ لِلرَّحۡمَٰنِ فَلَا تَسۡمَعُ إِلَّا هَمۡسࣰ ا

On that Day, people will follow the summoner from whom there is no escape; every voice will be hushed for the Lord of Mercy; only whispers will be heard

Qur'ān 20:120English sense: whisperings

فَوَسۡوَسَ إِلَيۡهِ ٱلشَّيۡطَٰنُ قَالَ يَٰٓـَٔادَمُ هَلۡ أَدُلُّكَ عَلَىٰ شَجَرَةِ ٱلۡخُلۡدِ وَمُلۡكࣲ لَّا يَبۡلَىٰ

But Satan whispered to Adam, saying, ‘Adam, shall I show you the tree of immortality and power that never decays?’

Qur'ān 50:16English sense: whisperings

وَلَقَدۡ خَلَقۡنَا ٱلۡإِنسَٰنَ وَنَعۡلَمُ مَا تُوَسۡوِسُ بِهِۦ نَفۡسُهُۥۖ وَنَحۡنُ أَقۡرَبُ إِلَيۡهِ مِنۡ حَبۡلِ ٱلۡوَرِيدِ

We created man––We know what his soul whispers to him: We are closer to him than his jugular vein––

Qur'ān 7:20English sense: whisperings

فَوَسۡوَسَ لَهُمَا ٱلشَّيۡطَٰنُ لِيُبۡدِيَ لَهُمَا مَا وُۥرِيَ عَنۡهُمَا مِن سَوۡءَٰتِهِمَا وَقَالَ مَا نَهَىٰكُمَا رَبُّكُمَا عَنۡ هَٰذِهِ ٱلشَّجَرَةِ إِلَّآ أَن تَكُونَا مَلَكَيۡنِ أَوۡ تَكُونَا مِنَ ٱلۡخَٰلِدِينَ

Satan whispered to them so as to expose their nakedness, which had been hidden from them: he said, ‘Your Lord only forbade you this tree to prevent you becoming angels or immortals,’

Tafsīr

التفسير6 shown

Commentary on the verses above, at most two editions per verse.

en-al-jalalayn on 114:4en-al-jalalayncommentary on an ayah this subject surfaced

from the evil of the slinking whisperer Satan — he is referred to by the name of the action waswasa on account of his repeated engaging in it — who slinks away and recoils from the heart whenever God is mentioned

en-tafisr-ibn-kathir on 114:4en-tafisr-ibn-kathircommentary on an ayah this subject surfaced

Say: "I seek refuge with the Lord of An-Nas, (1)"The King of An-Nas, (2)"The God of An-Nas, (3)"From the evil of the whisperer who withdraws. (4)"Who whispers in the breasts of An-Nas. (5)"Of Jinn and An-Nas. (6) These are three attributes from the attributes of the Lord, the Mighty and Majestic. They are lordship, sovereignty and divinity. Thus, He is the Lord of everything, the King of everything and the God of everything. All things are created by Him, owned by Him, and subservient to Him. Therefore, He commands whoever is seeking protection to seek refuge with the One Who has these attributes from the evil of the whisperer who withdraws. This (the whisperer) is the devil that is assigned to man. For verily, there is not any of the Children of Adam except that he has a companion that beautifies wicked deeds for him. This devil will go to any lengths to confuse and confound him. The o

en-asbab-al-nuzul-by-al-wahidi on 7:20en-asbab-al-nuzul-by-al-wahidicommentary on an ayah this subject surfaced

Then Satan whispered to them to show them their shameful parts that were hidden from them. This also is a mark of solicitude and a proof of generosity, for they sinned, but He turned it over to Satan's whispering. Then He increased the solicitude. He said, “to show them their shameful parts that were hidden from them.” He said: “He made their pudenda appear to them, but not to others.” They say that afterwards, Adam and Iblis met. Adam said, “You wretch! Do you know what you did to me and what dust you stirred up in my road?” Iblis said, “O Adam, I take it that I took you from the road. Tell me then, who took me from the road?” They also say that both of them turned away from the command, but there is a difference be- tween the two. Adam slipped because of appetite, and Iblis slipped because of pride. Being pride- ful is worse than satisfying appetite. When a sin arises from appetite, th

en-al-jalalayn on 19:98en-al-jalalayncommentary on an ayah this subject surfaced

And how many — in other words many — a generation namely how many a community from among the communities of the past We have destroyed before them for their denial of Our messengers. Can you see can you find so much as one of them or hear from them so much as the faintest sound? No indeed! So just as We destroyed those folk We shall destroy these Meccans.

en-al-jalalayn on 7:20en-al-jalalayncommentary on an ayah this subject surfaced

Then Satan Iblīs whispered to them that he might manifest reveal to them that which was hidden wūriya based on the verbal form fū‘ila and derives from the infinitive al-muwārā to them of their shameful parts. And he said ‘Your Lord prohibited you from this tree only in aversion lest you become angels malakayn may also be read malikayn or become immortals’ in other words that is the necessary consequence of eating from it as is stated in another verse Shall I guide you to the Tree of Immortality and a kingdom that does not waste away? Q. 20120.

en-tafisr-ibn-kathir on 19:98en-tafisr-ibn-kathircommentary on an ayah this subject surfaced

Verily, those who believe and work deeds of righteousness, the Most Gracious will bestow love for them (96)So, We have made this easy in your own tongue, only that you may give glad tidings to those who have Taqwa, and warn with it the people that are Ludda (97)And how many a generation before them have We destroyed! Can you find a single one of them or hear even a whisper of them (98) Allah places Love of the Righteous People in the Hearts Allah, the Exalted, informs about His believing servants, who work righteous deeds – deeds that He is pleased with because they are in accordance with the legislation of Muhammad ﷺ – that He plants love for them in the hearts of His righteous servants. This is something that is absolutely necessary and there is no avoiding it. This has been reported in authentic Hadiths of the Messenger of Allah ﷺ in various different ways. Imam Ahmad recorded that

Ḥadīth

الحديث6 shown

Sound narrations only, and never matched by text. A narration appears here because a compiler filed it under a chapter this subject maps to, or because someone read it and anchored it. Each row says which.

Sahih al-Bukhari 1225Forgetfulness In Prayerfiled here by the compiler

حَدَّثَنَا عَبْدُ اللَّهِ بْنُ يُوسُفَ، أَخْبَرَنَا مَالِكٌ، عَنْ يَحْيَى بْنِ سَعِيدٍ، عَنْ عَبْدِ الرَّحْمَنِ الأَعْرَجِ، عَنْ عَبْدِ اللَّهِ ابْنِ بُحَيْنَةَ ـ رضى الله عنه ـ أَنَّهُ قَالَ إِنَّ رَسُولَ اللَّهِ صلى الله عليه وسلم قَامَ مِنِ اثْنَتَيْنِ مِنَ الظُّهْرِ لَمْ يَجْلِسْ بَيْنَهُمَا، فَلَمَّا قَضَى صَلاَتَهُ سَجَدَ سَجْدَتَيْنِ ثُمَّ سَلَّمَ بَعْدَ ذَلِكَ‏.‏

Narrated `Abdullah bin Buhaina:Allah's Messenger (ﷺ) got up after the second rak`a of the Zuhr prayer without sitting in between (the second and the third rak`at). When he finished the prayer he performed two prostrations (of Sahu) and then finished the prayer with Taslim

Sahih al-Bukhari 1226Forgetfulness In Prayerfiled here by the compiler

حَدَّثَنَا أَبُو الْوَلِيدِ، حَدَّثَنَا شُعْبَةُ، عَنِ الْحَكَمِ، عَنْ إِبْرَاهِيمَ، عَنْ عَلْقَمَةَ، عَنْ عَبْدِ اللَّهِ ـ رضى الله عنه ـ أَنَّ رَسُولَ اللَّهِ صلى الله عليه وسلم صَلَّى الظُّهْرَ خَمْسًا فَقِيلَ لَهُ أَزِيدَ فِي الصَّلاَةِ فَقَالَ ‏ "‏ وَمَا ذَاكَ ‏"‏‏.‏ قَالَ صَلَّيْتَ خَمْسًا‏.‏ فَسَجَدَ سَجْدَتَيْنِ بَعْدَ مَا سَلَّمَ‏.‏

Narrated' `Abdullah:Once Allah's Messenger (ﷺ) offered five rak`at in the Zuhr prayer, and somebody asked him whether there was some increase in the prayer. Allah's Messenger (ﷺ) said, "What is that?" He said, "You have offered five rak`at." So Allah's Messenger (ﷺ) performed two prostrations of Sahu after Taslim

Sunan an-Nasa'i 396Ghusl And Tayammumfiled here by the compiler

أَخْبَرَنَا سُلَيْمَانُ بْنُ دَاوُدَ، وَالْحَارِثُ بْنُ مِسْكِينٍ، قِرَاءَةً عَلَيْهِ وَأَنَا أَسْمَعُ، عَنِ ابْنِ وَهْبٍ، عَنْ عَمْرِو بْنِ الْحَارِثِ، عَنْ بُكَيْرٍ، أَنَّ أَبَا السَّائِبِ، حَدَّثَهُ أَنَّهُ، سَمِعَ أَبَا هُرَيْرَةَ، يَقُولُ قَالَ رَسُولُ اللَّهِ صلى الله عليه وسلم ‏‏ "‏‏ لاَ يَغْتَسِلْ أَحَدُكُمْ فِي الْمَاءِ الدَّائِمِ وَهُوَ جُنُبٌ ‏‏"‏‏ ‏‏.‏‏

Abu Hurairah said:"The Messenger of Allah (ﷺ) said: 'None of you should perform ghusl in standing water while he is Junub

Sunan an-Nasa'i 397Ghusl And Tayammumfiled here by the compiler

أَخْبَرَنَا مُحَمَّدُ بْنُ حَاتِمٍ، قَالَ حَدَّثَنَا حِبَّانُ، قَالَ حَدَّثَنَا عَبْدُ اللَّهِ، عَنْ مَعْمَرٍ، عَنْ هَمَّامِ بْنِ مُنَبِّهٍ، عَنْ أَبِي هُرَيْرَةَ، عَنِ النَّبِيِّ صلى الله عليه وسلم قَالَ ‏‏ "‏‏ لاَ يَبُولَنَّ الرَّجُلُ فِي الْمَاءِ الدَّائِمِ ثُمَّ يَغْتَسِلُ مِنْهُ أَوْ يَتَوَضَّأُ ‏‏"‏‏ ‏‏.‏‏

It was narrated from Abu Hurairah that the Messenger of Allah (ﷺ) said:"None of you should urinate into standing water and then perform Ghusl or Wudu' with it

Sunan an-Nasa'i 5428Seeking Refuge With Allahfiled here by the compiler

أَخْبَرَنَا أَبُو عَبْدِ الرَّحْمَنِ، أَحْمَدُ بْنُ شُعَيْبٍ قَالَ أَنْبَأَنَا عَمْرُو بْنُ عَلِيٍّ، قَالَ حَدَّثَنَا أَبُو عَاصِمٍ، قَالَ حَدَّثَنَا ابْنُ أَبِي ذِئْبٍ، قَالَ حَدَّثَنِي أَسِيدُ بْنُ أَبِي أَسِيدٍ، عَنْ مُعَاذِ بْنِ عَبْدِ اللَّهِ، عَنْ أَبِيهِ، قَالَ أَصَابَنَا طَشٌّ وَظُلْمَةٌ فَانْتَظَرْنَا رَسُولَ اللَّهِ صلى الله عليه وسلم لِيُصَلِّيَ بِنَا ثُمَّ ذَكَرَ كَلاَمًا مَعْنَاهُ فَخَرَجَ رَسُولُ اللَّهِ صلى الله عليه وسلم لِيُصَلِّيَ بِنَا فَقَالَ ‏"‏ قُلْ ‏"‏ ‏.‏ فَقُلْتُ مَا أَقُولُ قَالَ ‏"‏ ‏{‏ قُلْ هُوَ اللَّهُ أَحَدٌ ‏}‏ وَالْمُعَوِّذَتَيْنِ حِينَ تُمْسِي وَحِينَ تُصْبِحُ ثَلاَثًا يَكْفِيكَ كُلَّ شَىْءٍ ‏"‏ ‏.‏

It was narrated from Mu'adh bin 'Abdullah that his father said:"It was raining and dark, and we were waiting for the Messenger of Allah [SAW] to lead us in prayer. Then the Messenger of Allah [SAW] came out to lead us in prayer and he said: 'Say.' I said: 'What should I say?' He said: 'Say: He is Allah, (the) One and Al-Mu'awwadhatain in the evening and in the morning, three times, and that will suffice you against everything

Sunan an-Nasa'i 5430Seeking Refuge With Allahfiled here by the compiler

أَخْبَرَنَا مُحَمَّدُ بْنُ عَلِيٍّ، قَالَ حَدَّثَنِي الْقَعْنَبِيُّ، عَنْ عَبْدِ الْعَزِيزِ، عَنْ عَبْدِ اللَّهِ بْنِ سُلَيْمَانَ، عَنْ مُعَاذِ بْنِ عَبْدِ اللَّهِ بْنِ خُبَيْبٍ، عَنْ أَبِيهِ، عَنْ عُقْبَةَ بْنِ عَامِرٍ الْجُهَنِيِّ، قَالَ بَيْنَا أَنَا أَقُودُ، بِرَسُولِ اللَّهِ صلى الله عليه وسلم رَاحِلَتَهُ فِي غَزْوَةٍ إِذْ قَالَ ‏"‏ يَا عُقْبَةُ قُلْ ‏"‏ ‏.‏ فَاسْتَمَعْتُ ثُمَّ قَالَ ‏"‏ يَا عُقْبَةُ قُلْ ‏"‏ ‏.‏ فَاسْتَمَعْتُ فَقَالَهَا الثَّالِثَةَ فَقُلْتُ مَا أَقُولُ فَقَالَ ‏"‏ ‏{‏ قُلْ هُوَ اللَّهُ أَحَدٌ ‏}‏ ‏"‏ ‏.‏ فَقَرَأَ السُّورَةَ حَتَّى خَتَمَهَا ثُمَّ قَرَأَ ‏{‏ قُلْ أَعُوذُ بِرَبِّ الْفَلَقِ ‏}‏ وَقَرَأْتُ مَعَهُ حَتَّى خَتَمَهَا ثُمَّ قَرَأَ ‏{‏ قُلْ أَعُوذُ بِرَبِّ النَّاسِ ‏}‏ فَقَرَأْتُ مَعَهُ حَتَّى خَتَمَهَا ثُمَّ قَالَ ‏"‏ مَا تَعَوَّذَ بِمِثْلِهِنَّ أَحَدٌ ‏"‏ ‏.‏

It was narrated that 'Uqbah bin 'Amir Al-Juhani said:"While I was leading the Messenger of Allah [SAW] on his mount on a military campaign, he said: 'O 'Uqbah, say!' I listened, then he said: 'O 'Uqbah, say!' I listened, then he said it a third time. I said: 'What should I say?' He said: 'Say: He is Allah, (the) One...' and he recited the Surah to the end. Then he recited: 'Say: I seek refuge with (Allah) the Lord of the daybreak...' and I recited it with him until the end. Then he recited: 'Say: I seek refuge with (Allah) the Lord of mankind...' and I recited it with him until the end. Then he said: 'No one ever sought refuge (with Allah) by means of anything like them

Classical works

كتب التراث6 shown

Arabic originals, reached through the subject’s Arabic senses. Interpretive sources, never proof of a ruling.

ihya §1219ihyaArabic sense: الشيطان, الوسواس, شيطان, وسواس

فإن كان يؤذيه ذلك فليرش عليه الماء حتى يقوى في نفسه ذلك ولا يتسلط عليه الشيطان بالوسواس

ihya §10762ihyaArabic sense: الوسواس, وسواس, وسوسة

ولم يجدوا إلا الوسواس والكراهة له ولا يمكن أن يقال أراد بصريح الإيمان الوسوسة فلم يبق إلا حمله على الكراهة المساوقة للوسوسة والرياء وإن كان عظيما فهو دون الوسوسة في حق الله تعالى فإذا اندفع ضرر الأعظم بالكراهة فبأن يندفع بها ضرر الأصغر أولى وكذلك يروى عن النبي صلى الله عليه وسلم في حديث ابن عباس أنه قال الحمد لله الذي رد كيد الشيطان إلى الوسوسة + حديث ابن عباس الحمد لله الذي رد كيد الشيطان إلى الوسوسة أخرجه أبو داود والنسائي في اليوم والليلة بلفظ كيده

ihya §8846ihyaArabic sense: الشيطان, شيطان, وسوسة

| بيان تسلط الشيطان على القلب بالوساوس ومعنى الوسوسة وسبب غلبتها

ihya §1658ihyaArabic sense: الوسواس, وسواس, وسوسة

وكان بعضهم يخفف الصلاة خيفة الوسواس وروى أن عمار بن ياسر صلى صلاة فأخفها فقيل له خففت يا أبا اليقظان فقال هل رأيتموني نقصت من حدودها شيئا قالوا لا قال إني بادرت سهو الشيطان إن رسول الله صلى الله عليه وسلم قال إن العبد ليصلي الصلاة لا يكتب له نصفها ولا ثلثها ولا ربعها ولا خمسها ولا سدسها ولا عشرها وكان يقول إنما يكتب للعبد من صلاته ما عقل منها + حديث إن عمار بن ياسر صلى فأخفها فقيل له خففت يا أبا اليقظان الحديث @QB@ وفيه @QE@ إن العبد ليصلي صلاة لا يكتب له نصفها ولا ثلثها إلى آخره أخرجه أحمد بإسناد صحيح وتقدم المرفوع عنه وهو عند أبي داود والنسائي + ويقال إن طلحة والزبير وطائفة من الصحابة رضي الله عنهم كانوا أخف الناس صلاة وقالوا نبادر بها وسوسة الشيطان

ihya §4761ihyaArabic sense: الوسواس, وسواس, وسوسة

وقد كره السلف بيع السيف في وقت الفتنة خيفة أن يشتريه ظالم فهذا ورع فوق الأول والكراهية فيه أخف ويليه ما هو مبالغة ويكاد يلتحق بالوسواس وهو قول جماعة أنه لا تجوز معاملة الفلاحين بآلات الحارث لأنهم يستعينون بها على الحراثة ويبيعون الطعام من الظلمة ولا يباع منهم البقر والفدان وآلات الحرث وهذا ورع الوسوسة إذ ينجر إلى أن لا يباع من الفلاح طعام لأنه يتقوى به على الحراثة ولا يسقي من الماء العام لذلك وينتهي هذا حد التنطع المنهي عنه وكل متوجه إلى شيء على قصد خير لا بد وأن يسرف إن لم يذمه العلم المحقق وربما يقدم على ما يكون بدعة في الدين ليستضر الناس بعده بها وهو يظن أنه مشغول بالخير ولهذا قال صلى الله عليه وسلم فضل العالم على العابد كفضلي على أدنى رجل من أصحابي +

ihya §8905ihyaArabic sense: الوسواس, وسواس, وسوسة

وقالت فرقة الوسوسة والذكر يتساوقان في الدوام على القلب تساوقا لا ينقطع وكما أن الإنسان قد يرى بعينيه شيئين في حالة واحدة فكذلك القلب قد يكون مجرى لشيئين فقد قال صلى الله عليه وسلم ما من عبد إلا وله أربعة أعين عينان في رأسه يبصر بهما أمر دنياه وعينان في قلبه يبصر بهما أمر دينه + حديث ما من عبد إلا وله أربعة أعين عينان في رأسه يبصر بهما أمر دنياه وعينان في قلبه يبصر بهما أمر دينه أخرجه أبو منصور الديلمي في مسند الفردوس من حديث معاذ بلفظ الآخرة مكان دينه وفيه الحسين بن أحمد بن محمد الهروي السماخي الحافظ كذبه الحاكم والآفة منه وإلى هذا ذهب المحاسبي والصحيح عندنا أن كل هذه المذاهب صحيحة ولكن كلها قاصرة عن الإحاطة بأصناف الوسواس وإنما نظر كل واحد منهم إلى صنف واحد من الوسواس فأخبر عنه

Research library

المكتبة البحثية548 works held

Peer-reviewed work held with its DOI and abstract, labelled with the study design its publication types report. None of it has been read or assessed, so nothing here may be cited as showing anything. Retracted work is held for the record but never listed; a review that a later version replaced is listed under its replacement and marked.

10.1016/j.cpr.2011.09.008Clinical psychology review (2011)MEDLINE-indexed journal, not yet read by us; matched on Obsessive-Compulsive Disorder, Compulsive Behavior, Obsessive Behavior, obsessive-compulsive, compulsions

Etiology of obsessions and compulsions: a meta-analysis and narrative review of twin studies.: The relative importance of genetic and environmental factors in the etiology of obsessive-compulsive (OC) symptoms is unclear. Cognitive-behavioral models propose that shared environment (e.g., parenting style) is important. Family segregation studies suggest that nonadditive genetic factors may be involved. To investigate the etiology of OC symptoms, a meta-analysis was conducted of 37 twin samples from 14 studies, supplemented by a narrative review. Results indicated that in terms of mean effe

10.1016/j.comppsych.2020.152167Comprehensive psychiatry (2020)MEDLINE-indexed journal, not yet read by us; matched on Obsessive-Compulsive Disorder, Compulsive Behavior, obsessive-compulsive, compulsions

Is cyberchondria a new transdiagnostic digital compulsive syndrome? A systematic review of the evidence.: Background: Cyberchondria (CYB) has been described relatively recently as a behaviour characterized by excessive online searching for medical information that is associated with increasing levels of health anxiety. Although CYB has received some attention from researchers, there is no consensus about many of its aspects. Aims: We describe one of the first reported cases of a treatment-seeking patient with CYB. We review the published literature on the definition of CYB, its assessment, epidemiol

10.1016/j.jad.2020.07.140Journal of affective disorders (2020)MEDLINE-indexed journal, not yet read by us; matched on Obsessive-Compulsive Disorder, Obsessive-Compulsive Disorder, obsessive-compulsive, compulsions

Family and couple integrated cognitive-behavioural therapy for adults with OCD: A meta-analysis.: Background: Integrating family into the treatment of obsessive-compulsive disorder (OCD) is standard in pediatric populations; however, in adult populations, patients are typically treated independent of their family. Yet, there is compelling evidence to suggest that family members exacerbate OCD symptoms, and thus there is a strong rationale for integrating family members into the treatment of adult OCD. The present meta-analysis examined whether family treatment is effective for OCD in adult p

10.1080/13651501.2022.2151474International journal of psychiatry in clinical practice (2023)MEDLINE-indexed journal, not yet read by us; matched on Obsessive-Compulsive Disorder, Obsessive-Compulsive Disorder, obsessive-compulsive, compulsions

Effects of exercise on obsessive-compulsive disorder symptoms: a systematic review and meta-analysis.: Objective: This systematic review and meta-analysis assessed the efficacy of exercise in reducing OCD symptoms. Methods: We searched PubMed, Cochrane Central Register of Controlled Trials, MEDLINE, Scopus and grey literature until March 2022. The study was preregistered at Prospero (CRD42021283931). We included randomised controlled and pre-post trials assessing physical activity as an intervention for OCD. Risk of bias was assessed using the Cochrane ROBINS-I tool and the RoB2 tool. Results: Th

10.1080/16506073.2023.2211736Cognitive behaviour therapy (2023)MEDLINE-indexed journal, not yet read by us; matched on Obsessive-Compulsive Disorder, Obsessive-Compulsive Disorder, obsessive-compulsive, compulsions

Associations between perfectionism and symptoms of anxiety, obsessive-compulsive disorder and depression in young people: a meta-analysis.: Perfectionism is a transdiagnostic process contributing to the onset and maintenance of anxiety, obsessive-compulsive disorder (OCD) and depression. The aim of this systematic review and meta-analysis was to examine the association between perfectionism, and symptoms of anxiety, OCD and depression among young people aged 6-24 years. A systematic literature search retrieved a total of 4,927 articles, with 121 studies included (Mpooled age = ~17.70 years). Perfectionistic concerns demonstrated sig

10.1176/appi.ajp.2016.16020201The American journal of psychiatry (2017)MEDLINE-indexed journal, not yet read by us; matched on Obsessive-Compulsive Disorder, Obsessive-Compulsive Disorder, obsessive-compulsive, compulsions

Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis.: Objective: Structural brain imaging studies in obsessive-compulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted meta- and mega-analyses of data from OCD sites worldwide. Method: T1 images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coo

Research library, full list

126 to 150 of 548
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R (2015)systematic reviewMEDLINE-indexed journal, not yet read by usNeuroscience and biobehavioral reviews293 citations

Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review.

N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. Over the past decade, there has been growing evidence for the use of NAC in treating psychiatric and neurological disorders, considering its role in attenuating pathophysiological processes associated with these disorders, including oxidative stress, apoptosis, mitochondrial dysfunction, neuroinflammation and glutamate and dopamine dysregulation. In this systematic review we find favorable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer's disease, cocaine and cannabis addiction, bipolar disorder, depression, trichotillomania, nail biting, skin picking, obsessive-compulsive disorder, schizophrenia, drug-induced neuropathy and progressive myoclonic epilepsy. Disorders such as anxiety, attention deficit hyperactivity disorder and mild

matched on obsessive-compulsive (text), compulsions (text)

Mitchell RH, Goldstein BI (2014)systematic reviewMEDLINE-indexed journal, not yet read by usJournal of the American Academy of Child and Adolescent Psychiatry194 citations

Inflammation in children and adolescents with neuropsychiatric disorders: a systematic review.

Objective: There has been rapid growth in research regarding inflammation in neuropsychiatric disorders as it relates to youth. We therefore set out to systematically review the literature on inflammation and neuropsychiatric disorders in children and adolescents. Method: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies were included if proinflammatory markers (PIMs) in children and/or adolescents with neuropsychiatric disorders were measured. Results: Sixty-seven studies were included, involving 3,952 youth. Evidence for a proinflammatory state is strongest for autism spectrum disorders (ASD). PIMs are elevated in children and adolescents with major depressive disorder (MDD), bipolar disorder (BD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD),

matched on obsessive-compulsive (text), compulsions (text)

Goodman JH, Chenausky KL, Freeman MP (2014)systematic reviewMEDLINE-indexed journal, not yet read by usThe Journal of clinical psychiatry129 citations

Anxiety disorders during pregnancy: a systematic review.

Objective: To systematically evaluate the literature on anxiety disorders during pregnancy. Data sources: MEDLINE, PsycINFO, and CINAHL were searched through October 2013 for original research studies published in English using combinations of the terms pregnancy, prenatal, or pregnancy outcomes; anxiety disorder; and generalized anxiety. Reference lists of included studies were hand-searched and a PubMed search for in-process reports was conducted. Study selection: Relevant studies of anxiety disorders during pregnancy as determined by diagnostic interview were included if they reported on prevalence; course, onset, and/or risk factors; maternal, obstetric, or fetal/child outcomes; and/or treatment trial results. Data extraction: Two reviewers independently extracted relevant data and assessed methodological quality of each study. Results: Fifty-seven reports were included. Reports prov

matched on obsessive-compulsive (text), compulsions (text)

Conversano C, Marazziti D, Carmassi C, Baldini S, Barnabei G, Dell'Osso L (2012)systematic reviewMEDLINE-indexed journal, not yet read by usHarvard review of psychiatry35 citations

Pathological gambling: a systematic review of biochemical, neuroimaging, and neuropsychological findings.

Pathological gambling is an emerging psychiatric disorder that has recently gained much attention because of its increasing prevalence and devastating personal, familial, and social consequences. Although its pathophysiology is largely unknown, the shared similarities with both addiction and obsessive-compulsive spectrum disorders have suggested the possibility of common psychobiological substrates. As with many other psychiatric disorders, it is believed that pathological gambling may result from the interplay between individual vulnerability and environmental factors. The aim of this article is to offer a comprehensive review of the main neurobiological aspects of pathological gambling, with particular attention to neuropsychological and related findings. A deeper understanding of the biological correlates of pathological gambling is required in order to develop effective treatment str

matched on obsessive-compulsive (text), compulsions (text)

Pilkington K, Kirkwood G, Rampes H, Cummings M, Richardson J (2007)systematic reviewMEDLINE-indexed journal, not yet read by usAcupuncture in medicine : journal of the British Medical Acupuncture Society112 citations

Acupuncture for anxiety and anxiety disorders--a systematic literature review.

Introduction: The aim of this study was to evaluate the evidence for the efficacy of acupuncture in the treatment of anxiety and anxiety disorders by systematic review of the relevant research. Methods: Searches of the major biomedical databases (MEDLINE, EMBASE, ClNAHL, PsycINFO, Cochrane Library) were conducted between February and July 2004. Specialist complementary medicine databases were also searched and efforts made to identify unpublished research. No language restrictions were imposed and translations were obtained where necessary. Study methodology was appraised and clinical commentaries obtained for studies reporting clinical outcomes. Results: Twelve controlled trials were located, of which 10 were randomised controlled trials (RCTs). Four RCTs focused on acupuncture in generalised anxiety disorder or anxiety neurosis, while six focused on anxiety in the perioperative period.

matched on obsessive-compulsive (text), compulsions (text)

Kaltenthaler E, Brazier J, De Nigris E, Tumur I, Ferriter M, Beverley C, Parry G, Rooney G, Sutcliffe P (2006)systematic reviewMEDLINE-indexed journal, not yet read by usHealth technology assessment (Winchester, England)156 citations

Computerised cognitive behaviour therapy for depression and anxiety update: a systematic review and economic evaluation.

Objectives: To evaluate computerised cognitive behaviour therapy (CCBT) for the treatment of anxiety, depression, phobias, panic and obsessive-compulsive behaviour (OCD). The software packages to be considered include Beating the Blues (BtB), Overcoming Depression: a five areas approach, FearFighter (FF), Cope and BT Steps. Other packages or programmes incorporating CCBT were also considered. Data sources: Electronic databases from 1966 to March 2004. Evidence submitted by sponsors for CCBT products. Review methods: A systematic review was a review of the literature and the evidence submitted by sponsors for each of the products. A series of cost-effectiveness models was developed and run by the project team for the five CCBT products across the three mental health conditions. Results: Twenty studies were identified in the clinical effectiveness review. The analysis of these results show

matched on obsessive-compulsive (text), compulsions (text)

Alagöz E, Tonkuş MB (2026)cohort or longitudinalMEDLINE-indexed journal, not yet read by usJournal of religion and health

Psychometric Properties of the Belief in Divine Retribution Scale: Turkish Version, Validity, and Reliability Study in Turkey.

Belief systems significantly influence individuals' cognitive and emotional processes. Among these, belief in divine retribution notably affects moral behavior and provides a framework for interpreting life's challenges. This study aimed to adapt the Belief in Divine Retribution Scale (BDRS) into Turkish and to examine its psychometric properties in a Turkish sample. Convergent validity was further evaluated by investigating the relationship between the BDRS and religious obsessions. This methodological study included 425 participants aged 18 years and older residing in Turkey. The adaptation process involved translation, back-translation, expert review, and pilot testing. The adaptation process followed established guidelines for cross-cultural validation of religious and spiritual measures. Data were collected using the Belief in Divine Retribution Scale, the Penn Inventory of Scrupulo

matched on Obsessive-Compulsive Disorder (mesh), scrupulosity (text)

Smith KE, Mason TB, Lavender JM (2018)meta-analysisMEDLINE-indexed journal, not yet read by usClinical psychology review117 citations

Rumination and eating disorder psychopathology: A meta-analysis.

Rumination is a cognitive process involving repetitive thoughts about negative experiences and emotions and is associated with psychopathology. Rumination has been implicated in mood and anxiety disorders, and there is a growing body of research on rumination in relation to eating disorder (ED) psychopathology. The current meta-analytic review focused on the literature addressing rumination and ED psychopathology. A comprehensive search process identified 38 studies, which primarily used cross-sectional designs with non-clinical samples. Results demonstrated that rumination was concurrently (r = 0.33) and prospectively (r = 0.22-0.23) associated with ED psychopathology, and that groups with ED psychopathology evidenced higher levels of rumination compared to non-ED control groups (g = 0.95), though no significant differences in rumination were observed when comparing anorexia nervosa to

matched on Obsessive Behavior (mesh)

Hudson JL, Rapee RM, Lyneham HJ, McLellan LF, Wuthrich VM, Schniering CA (2015)cohort or longitudinalMEDLINE-indexed journal, not yet read by usBehaviour research and therapy93 citations

Comparing outcomes for children with different anxiety disorders following cognitive behavioural therapy.

Objective: The purpose of this study was to compare treatment outcomes following a group family-based cognitive behavioural therapy for children with different anxiety disorders (social anxiety disorder, separation anxiety disorder, generalised anxiety disorder, specific phobia and obsessive compulsive disorder). Method: This study utilised a clinical sample of 842 children and adolescents (aged between 6 and 18 years) and assessed outcome using diagnostic interview, parent-report and child-report. Results: Based on diagnostic data and parent-reported symptoms, results revealed that children with a diagnosis of social anxiety disorder experienced a slower rate of change and poorer diagnostic outcomes at post treatment and follow-up than children with other anxiety disorders. Children with GAD showed better response to this broad-based intervention and children with OCD showed better resp

matched on Obsessive-Compulsive Disorder (mesh), compulsions (text)

Khayer E, Zarei R, Damghanian M, Bőthe B, Farnam F (2024)MEDLINE-indexed journal, not yet read by usJournal of behavioral addictions3 citations

Compulsive sexual behaviour in Iranian married women: Prevalence, sociodemographic, sexual, and psychological predictors across-country.

Background and aims: This study addresses the scarcity of research on Compulsive Sexual Behavior Disorder (CSBD) in non-Western cultures and women, exploring its prevalence, sociodemographic, sexual history characteristics, and sexual and psychological health factors in Iranian married women. Methods: A cross-sectional study involving 772 heterosexual married women was conducted between 2022 and 2023, covering all 31 provinces of Iran. Participants were categorized as CSBD+ (at-risk individuals) and CSBD- (low-risk individuals) based on a pre-established cut-off point of ≥18 by the Compulsive Sexual Behavior Disorder Scale -7. Depression, anxiety, obsessive-compulsive disorder, self-esteem, sexual distress, sexual satisfaction, relationship satisfaction, and sexual dysfunction were assessed as psychological and sexual health variables by standardized scales. Results: The prevalence of CS

matched on Obsessive-Compulsive Disorder (mesh), Compulsive Behavior (mesh), Obsessive-Compulsive Disorder (keyword), obsessive-compulsive (text), compulsions (text)

Wetterneck CT, Rouleau TM, Williams MT, Vallely A, La Torre JT, Björgvinsson T (2021)MEDLINE-indexed journal, not yet read by usBehavior therapy3 citations

A New Scrupulosity Scale for the Dimensional Obsessive-Compulsive Scale (DOCS): Validation With Clinical and Nonclinical Samples.

Scrupulous obsessions are a prominent presentation of obsessive-compulsive disorder (OCD). Previous conceptualizations of scrupulosity have indicated that it belongs to the unacceptable thoughts dimension, which pertains to sexual, violent, and religious obsessive themes. However, research suggests that scrupulous symptoms may differ from other unacceptable thoughts symptoms, necessitating the need for targeted and thorough assessment. We added a Scrupulous or Religious Thoughts subscale (DOCS-SR) to the Dimensional Obsessive-Compulsive Scale (DOCS) and tested its factorial structure, psychometric properties, and clinical correlates in a nonclinical and clinical sample. In the first study, nonclinical participants (N = 203) completed the DOCS-SR, which was subjected to an exploratory factor analysis. Analyses revealed that the DOCS-SR reflected a one-factor solution and possessed accepta

matched on Obsessive-Compulsive Disorder (mesh), Obsessive-Compulsive Disorder (keyword), Obsessive Behavior (mesh), obsessive-compulsive (text), compulsions (text), scrupulosity (text)

Boelen PA, Carleton RN (2012)MEDLINE-indexed journal, not yet read by usThe Journal of nervous and mental disease44 citations

Intolerance of uncertainty, hypochondriacal concerns, obsessive-compulsive symptoms, and worry.

Intolerance of uncertainty (IU) has been found to be involved in several anxiety disorders, including generalized anxiety disorder and obsessive-compulsive disorder (OCD). Few studies have examined the role of IU in health anxiety (HA)/hypochondriacal concerns (HC). We conducted two studies exploring the associations between IU and HA/HC. The first study included undergraduates (n = 114) and indicated an association between IU and several HA/HC indices. When controlling for neuroticism, worry about illness was the single index of HA/HC that remained associated with IU. In the second study among bereaved adults (n = 126), IU was associated with one index of HA/HC but not when neuroticism and anxiety sensitivity were controlled. In both studies, IU was found to be more strongly associated with OCD symptoms and worry than with HA/HC.

matched on Obsessive-Compulsive Disorder (mesh), Compulsive Behavior (mesh), Obsessive Behavior (mesh), obsessive-compulsive (text), compulsions (text)

Castle D, Feusner J, Laposa JM, Richter PMA, Hossain R, Lusicic A, Drummond LM (2023)reviewMEDLINE-indexed journal, not yet read by usComprehensive psychiatry8 citations

Psychotherapies and digital interventions for OCD in adults: What do we know, what do we need still to explore?

Background: Despite significant advances in the understanding and treatment of obsessive compulsive disorder (OCD), current treatment options are limited in terms of efficacy for symptom remission. Thus, assessing the potential role of iterative or alternate psychotherapies is important. Also, the potential role of digital technologies to enhance the accessibility of these therapies, should not be underestimated. We also need to embrace the idea of a more personalized treatment choice, being cognisant of clinical, genetic and neuroimaging predictors of treatment response. Procedures: Non-systematic review of current literature on emerging psychological and digital therapies for OCD, as well as of potential biomarkers of treatment response. Findings: A number of 'third wave' therapies (e.g., Acceptance and Commitment Therapy, Mindfulness-Based Cognitive Therapy) have an emerging and encou

matched on Obsessive-Compulsive Disorder (mesh), Obsessive-Compulsive Disorder (keyword), compulsions (text)

Redden SA, Patel TA, Cougle JR (2022)randomised controlled trialMEDLINE-indexed journal, not yet read by usJournal of behavior therapy and experimental psychiatry6 citations

Computerized treatment of perfectionism through mistake making: A preliminary study.

Background and objectives: Perfectionism has important implications for self-worth, personal standards, and psychopathology. The aim of this study was to test the efficacy of a novel two-week, computerized, exposure-based treatment for perfectionism (ETP). Methods: Seventy-one university students with elevated perfectionism were randomized to either the ETP group (n = 36) or the waitlist (WL) control group (n = 35). The ETP group was asked to complete the intervention at home, every three days for two weeks for a total of five treatment sessions. The tasks in the ETP condition were engineered to have participants repeatedly make mistakes. All participants returned two weeks after the baseline visit for a post-treatment assessment. Results: Compared to WL, ETP led to lower overall perfectionism, concern over mistakes, personal standards, depressive symptoms, social anxiety symptoms, and e

matched on obsessive-compulsive (text), compulsions (text)

Ay DS, Kühne F, Weck F (2019)randomised controlled trialMEDLINE-indexed journal, not yet read by usClinical psychology & psychotherapy1 citations

The assessment of cognitive-behavioral therapy skills in patients diagnosed with health anxiety: Development and pilot study on an observer-based rating scale.

Cognitive-behavioral therapy is a highly effective treatment of health anxiety, but it remains unclear through which mechanisms treatment effects prevail. Some evidence suggests that patients acquire skills-understood as techniques helping them reach therapy goals-through psychotherapy. In the current study, an observer-based rating scale for the skills assessment of patients with health anxiety (SAPH) was developed and validated in a pilot study. Based on 177 videotapes, four independent raters evaluated the frequency of skills acquired during cognitive and exposure therapy among 66 patients diagnosed with health anxiety with the SAPH. Predictive validity was evaluated by the Yale-Brown Obsessive-Compulsive Scale for Hypochondriasis. The SAPH demonstrated good interrater reliability (ICC(1,2)  = .88, p < .001, 95% CI [.81, .92]) and internal consistency (α = .94). Although patient skill

matched on obsessive-compulsive (text), compulsions (text)

Kuppens RJ, Donze SH, Hokken-Koelega AC (2016)randomised controlled trialMEDLINE-indexed journal, not yet read by usClinical endocrinology64 citations

Promising effects of oxytocin on social and food-related behaviour in young children with Prader-Willi syndrome: a randomized, double-blind, controlled crossover trial.

Background: Prader-Willi syndrome (PWS) is known for hyperphagia with impaired satiety and a specific behavioural phenotype with stubbornness, temper tantrums, manipulative and controlling behaviour and obsessive-compulsive features. PWS is associated with hypothalamic and oxytocinergic dysfunction. In humans without PWS, intranasal oxytocin administration had positive effects on social and eating behaviour, and weight balance. Objective and hypotheses: To evaluate the effects of intranasal oxytocin compared to placebo administration on social behaviour and hyperphagia in children with PWS. Design: Randomized, double-blind, placebo-controlled, crossover study in a PWS Reference Center in the Netherlands. Method: Crossover intervention with twice daily intranasal oxytocin (dose range 24-48 IU/day) and placebo administration, both during 4 weeks, in 25 children with PWS (aged 6 to 14 years

matched on obsessive-compulsive (text), compulsions (text)

Agras WS, Lock J, Brandt H, Bryson SW, Dodge E, Halmi KA, Jo B, Johnson C, Kaye W, Wilfley D, Woodside B (2014)randomised controlled trialMEDLINE-indexed journal, not yet read by usJAMA psychiatry170 citations

Comparison of 2 family therapies for adolescent anorexia nervosa: a randomized parallel trial.

Importance: Anorexia nervosa (AN) is a serious disorder with high rates of morbidity and mortality. Family-based treatment (FBT) is an evidence-based therapy for adolescent AN, but less than half of those who receive this approach recover. Hence, it is important to identify other approaches to prevent the development of the chronic form of AN for which there is no known evidence-based treatment. Objective: To compare FBT with systemic family therapy (SyFT) for the treatment of adolescent-onset AN. Design, setting, and participants: Research in Anorexia Nervosa (RIAN) is a 2-group (FBT and SyFT) randomized trial conducted between September 2005 and April 2012. Interviewers were blinded to the treatment condition. A total of 564 adolescents receiving care at 6 outpatient clinics experienced in the treatment of AN were screened. Of these, 262 adolescents did not meet the inclusion criteria

matched on obsessive-compulsive (text), compulsions (text)

Berlin HA, Braun A, Simeon D, Koran LM, Potenza MN, McElroy SL, Fong T, Pallanti S, Hollander E (2013)randomised controlled trialMEDLINE-indexed journal, not yet read by usThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry41 citations

A double-blind, placebo-controlled trial of topiramate for pathological gambling.

Objectives: Pathological gambling (PG) is an impulse control disorder characterized by recurrent gambling thoughts and behaviours that impair social functioning. Earlier studies suggested that topiramate may be effective in treating some impulse control disorders. We conducted the first randomized, controlled trial of topiramate in PG. Methods: PG patients were randomized to topiramate (N = 20) or placebo (N = 22) in this 14-week, double-blind, placebo-controlled, parallel-group trial. The primary outcome measure was change in the obsessions subscale of the Yale-Brown Obsessive-Compulsive Scale Modified for Pathological Gambling. Results: Mixed regression models (time [weeks] × treatment) revealed no significant treatment effect of topiramate on the primary or secondary outcome measures. The most statistically robust findings involved reducing the Barratt Impulsiveness Scale (BIS) total

matched on obsessive-compulsive (text), compulsions (text)

Moritz S, Rufer M (2011)randomised controlled trialMEDLINE-indexed journal, not yet read by usJournal of behavior therapy and experimental psychiatry19 citations

Movement decoupling: A self-help intervention for the treatment of trichotillomania.

Trichotillomania (TTM) is classified as an impulse control disorder characterized by the recurrent urge to pull out one's own hair resulting in noticeable hair loss. Cognitive-behavioral therapy, involving habit reversal training, currently represents the treatment of choice. The present study assessed the feasibility and effectiveness of a novel self-help technique, entitled decoupling (DC). DC aims at attenuating TTM by performing movements that decouple the behavioral elements involved in hair pulling. A total of 42 subjects with TTM were recruited via self-help forums for TTM and were randomized either to DC or progressive muscle relaxation (PMR). After four weeks, participants were asked to fill out the same questionnaires as before and rate the effectiveness of the intervention. The completion rate was high and the reliability of the assessments at least satisfactory. The DC group

matched on obsessive-compulsive (text), compulsions (text)

Rush AJ, Wisniewski SR, Warden D, Luther JF, Davis LL, Fava M, Nierenberg AA, Trivedi MH (2008)randomised controlled trialMEDLINE-indexed journal, not yet read by usArchives of general psychiatry124 citations

Selecting among second-step antidepressant medication monotherapies: predictive value of clinical, demographic, or first-step treatment features.

Context: Little is known about selecting among second-step medications for major depressive disorder after intolerance or lack of remission with an initial selective serotonin reuptake inhibitor. Objective: To determine whether sociodemographic, clinical, or first-step treatment features predict remission with or intolerance overall or differentially to any 1 of 3 second-step medications after an unsatisfactory outcome with citalopram hydrobromide. Design: An equipoise stratified randomized study. Participants were recruited from July 17, 2001, through April 20, 2004. Setting: Public or private sector primary care (n = 18) and psychiatric care (n = 23) settings across the United States. Participants: Representative outpatients aged 18 to 75 years with nonpsychotic major depressive disorder (N = 727). Interventions: Sustained-release bupropion hydrochloride was started at 150 mg/d and inc

matched on obsessive-compulsive (text), compulsions (text)

Maureen L.; Whittal; Melisa Robichaud and 4 others (2008)randomised controlled trialMEDLINE-indexed journal, not yet read by usJournal of Consulting and Clinical Psychology110 citations

Group and individual treatment of obsessive-compulsive disorder using cognitive therapy and exposure plus response prevention: A 2-year follow-up of two randomized trials.

Relatively little is known about the long-term durability of group treatments for obsessive-compulsive disorder (OCD) and contemporary cognitive treatments. The current study investigated the 2-year follow-up results for participants who completed randomized trials of group or individual treatment and received either cognitive therapy (CT) or exposure plus response prevention (ERP). Yale-Brown Obsessive Compulsive Scale (YBOCS) scores for individual ERP and CT were not significantly different over 2 years. However, YBOCS scores were consistently lower over time for group ERP participants than for group CT participants. With a single exception in the group treatment study, secondary cognitive and depression scores were stable, indicating that gains achieved during acute treatment were maintained over 2 years. Less than 10% of treatment completers relapsed in each of the treatment trials.

matched on obsessive-compulsive (text), compulsions (text)

Lock J, Agras WS, Bryson S, Kraemer HC (2005)randomised controlled trialMEDLINE-indexed journal, not yet read by usJournal of the American Academy of Child and Adolescent Psychiatry242 citations

A comparison of short- and long-term family therapy for adolescent anorexia nervosa.

Objective: Research suggests that family treatment for adolescents with anorexia nervosa may be effective. This study was designed to determine the optimal length of such family therapy. Method: Eighty-six adolescents (12-18 years of age) diagnosed with anorexia nervosa were allocated at random to either a short-term (10 sessions over 6 months) or long-term treatment (20 sessions over 12 months) and evaluated at the end of 1 year using the Eating Disorder Examination (EDE) between 1999 and 2002. Results: Although adequately powered to detect differences between treatment groups, an intent-to-treat analysis found no significant differences between the short-term and long-term treatment groups. Although a nonsignificant finding does not prove the null hypothesis, in no instance does the confidence interval on the effect size on the difference between the groups approach a moderate .5 level

matched on obsessive-compulsive (text), compulsions (text)

Dannon PN, Lowengrub K, Gonopolski Y, Musin E, Kotler M (2005)randomised controlled trialMEDLINE-indexed journal, not yet read by usClinical neuropharmacology63 citations

Topiramate versus fluvoxamine in the treatment of pathological gambling: a randomized, blind-rater comparison study.

Pathologic gambling (PG) is a highly prevalent and disabling impulse control disorder. Recent studies have demonstrated that PG patients respond well to treatment with SSRIs, mood stabilizers, and opioid antagonists. These findings support the idea that PG and other disorders of impulse control may be conceptualized as part of the obsessive-compulsive spectrum disorders. Pilot studies have shown topiramate to be effective in the treatment of specific disorders of impulse control. The aim of the study is to compare the effectiveness of topiramate versus fluvoxamine in the treatment of PG. Thirty-one male PGs were assigned in a randomized fashion to receive either topiramate (15/31) or fluvoxamine (16/31) pharmacotherapy for 12 weeks. A comprehensive psychiatric diagnostic evaluation was performed on all patients, and all patients were evaluated for symptoms of gambling, depression, and an

matched on obsessive-compulsive (text), compulsions (text)

Dannon PN, Lowengrub K, Musin E, Gonopolski Y, Kotler M (2005)randomised controlled trialMEDLINE-indexed journal, not yet read by usJournal of clinical psychopharmacology51 citations

Sustained-release bupropion versus naltrexone in the treatment of pathological gambling: a preliminary blind-rater study.

Background: Pathological gambling (PG) is a relatively common and highly disabling impulse control disorder. A range of psychotherapeutic agents, including selective serotonin reuptake inhibitors, mood stabilizers, and opioid antagonists, has been shown to be effective in the treatment of PG. The use of selective serotonin reuptake inhibitors and opioid antagonists for PG is consistent with the observation that PG shares features of both the obsessive-compulsive spectrum disorders and addictive disorders. The aim of the study is to compare the effectiveness of sustained-release bupropion versus naltrexone in the treatment of PG. Methods: Thirty-six male pathological gamblers were enrolled in our study. A comprehensive psychiatric diagnostic evaluation was performed at baseline on all patients, and patients were screened for symptoms of gambling, depression, and anxiety using the South Oa

matched on obsessive-compulsive (text), compulsions (text)

Stein DJ, Costa DLC, Lochner C, Miguel EC, Reddy YCJ, Shavitt RG, van den Heuvel OA, Simpson HB (2019)reviewMEDLINE-indexed journal, not yet read by usNature reviews. Disease primers535 citations

Obsessive-compulsive disorder.

Obsessive-compulsive disorder (OCD) is a highly prevalent and chronic condition that is associated with substantial global disability. OCD is the key example of the 'obsessive-compulsive and related disorders', a group of conditions which are now classified together in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and the International Classification of Diseases, 11th Revision, and which are often underdiagnosed and undertreated. In addition, OCD is an important example of a neuropsychiatric disorder in which rigorous research on phenomenology, psychobiology, pharmacotherapy and psychotherapy has contributed to better recognition, assessment and outcomes. Although OCD is a relatively homogenous disorder with similar symptom dimensions globally, individualized assessment of symptoms, the degree of insight, and the extent of comorbidity is needed. Several neurob

matched on Obsessive-Compulsive Disorder (mesh), obsessive-compulsive (text), compulsions (text)

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