Areas › Worry and anxiety › Treatment and medication
The first week or so on one of these can feel worse rather than better: jittery, restless, sleeping badly. For most people it settles within a fortnight, and it is a known part of starting rather than a sign of harm.
Untold, a person quite reasonably concludes the medicine is making them ill and stops. Told beforehand, the same week becomes something to sit out, and starting on a smaller dose usually takes the edge off it. Keep contact closer than usual through that stretch, particularly with young people, and ask directly how bad it is getting rather than waiting to be told.
This explains how treatments work. Never start, stop or change a medication because of something you read here.
Qur’an and Sunnah
So truly where there is hardship there is also ease (Quran 94:5). The two are named in the same breath, which is roughly what the first fortnight asks a person to believe.
فَإِنَّ مَعَ ٱلۡعُسۡرِ يُسۡرًا
So truly where there is hardship there is also ease
Qur’an 94:5read it in the library
Translation: M.A.S. Abdel Haleem, The Qur'an, Oxford University Press, 2004.
What the research says
In young people, antidepressants helped anxiety conditions more clearly than they helped depression, and the rise in reported suicidal thinking was small in absolute terms and outweighed by benefit for most, though it does warrant close monitoring early on. Pooling the trial data the regulator held gave the same picture: a small increase in suicidal thoughts and behaviour among children and adolescents, with no completed suicides in those trials. So the early weeks are the ones to watch, and watching closely is the sensible response rather than avoiding treatment.
Bridge JA, Iyengar S, Salary CB, Barbe RP, Birmaher B, Pincus HA, Ren L, Brent DA. (2007). Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials.. JAMA doi
Hammad TA, Laughren T, Racoosin J. (2006). Suicidality in pediatric patients treated with antidepressant drugs.. Archives of general psychiatry doi
Strength of evidence: one line of research. A single study, or a theoretical account.
Why it works
A rough patch you were expecting is something you can wait out, while an unexpected one looks like damage.
When not to
If distress climbs sharply or thoughts of self harm appear, that is not the ordinary settling period and needs contact with the prescriber the same day.
This one is still a draft. It is waiting on a scholar and a clinician to read it before it is published.
Near this one
There is an older antihistamine used for anxiety that works by making you drowsy and carries no risk of dependence. It suits a rough stretch, and it is a bridge rather than somewhere to settle.
How well something works in the moment and whether it is right for the long run are two separate questions. Fast relief is extremely convincing, which is exactly why it is worth pausing over.
The dose that lifts low mood is often not enough for anxiety, and for obsessive symptoms it is usually well short. Needing more of it is a feature of the problem rather than anything wrong with the person taking it.