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Diet and nutrition

What is eaten and how it bears on mind and body.

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Qurʾān

القرآن6 shown

Verses named for this subject by hand come first. The rest are found by the subject’s own Arabic and English senses and are shown as lexical matches, not as anchors anyone has confirmed.

Qur'ān 6:141English sense: eat | Arabic sense: تسرفوا, كلوا

۞وَهُوَ ٱلَّذِيٓ أَنشَأَ جَنَّٰتࣲ مَّعۡرُوشَٰتࣲ وَغَيۡرَ مَعۡرُوشَٰتࣲ وَٱلنَّخۡلَ وَٱلزَّرۡعَ مُخۡتَلِفًا أُكُلُهُۥ وَٱلزَّيۡتُونَ وَٱلرُّمَّانَ مُتَشَٰبِهࣰ ا وَغَيۡرَ مُتَشَٰبِهࣲۚ كُلُواْ مِن ثَمَرِهِۦٓ إِذَآ أَثۡمَرَ وَءَاتُواْ حَقَّهُۥ يَوۡمَ حَصَادِهِۦۖ وَلَا تُسۡرِفُوٓاْۚ إِنَّهُۥ لَا يُحِبُّ ٱلۡمُسۡرِفِينَ

It is He who produces both trellised and untrellised gardens, date palms, crops of diverse flavours, the olive, the pomegranate, alike yet different. So when they bear fruit, eat some of it, paying what is due on the day of harvest, but do not be wasteful: God does not like wasteful people

Qur'ān 7:31English sense: eat | Arabic sense: تسرفوا, كلوا

۞يَٰبَنِيٓ ءَادَمَ خُذُواْ زِينَتَكُمۡ عِندَ كُلِّ مَسۡجِدࣲ وَكُلُواْ وَٱشۡرَبُواْ وَلَا تُسۡرِفُوٓاْۚ إِنَّهُۥ لَا يُحِبُّ ٱلۡمُسۡرِفِينَ

Children of Adam, dress well whenever you are at worship, and eat and drink [as We have permitted] but do not be extravagant: God does not like extravagant people

Qur'ān 5:88Arabic sense: كلوا | English sense: eat, lawful and good

وَكُلُواْ مِمَّا رَزَقَكُمُ ٱللَّهُ حَلَٰلࣰ ا طَيِّبࣰ اۚ وَٱتَّقُواْ ٱللَّهَ ٱلَّذِيٓ أَنتُم بِهِۦ مُؤۡمِنُونَ

but eat the lawful and good things that God provides for you. Be mindful of God, in whom you believe

Qur'ān 25:20Arabic sense: الطعام, طعام | English sense: eat

وَمَآ أَرۡسَلۡنَا قَبۡلَكَ مِنَ ٱلۡمُرۡسَلِينَ إِلَّآ إِنَّهُمۡ لَيَأۡكُلُونَ ٱلطَّعَامَ وَيَمۡشُونَ فِي ٱلۡأَسۡوَاقِۗ وَجَعَلۡنَا بَعۡضَكُمۡ لِبَعۡضࣲ فِتۡنَةً أَتَصۡبِرُونَۗ وَكَانَ رَبُّكَ بَصِيرࣰ ا

No messenger have We sent before you [Muhammad] who did not eat food and walk about in the marketplace. But We have made some of you a means of testing others- will you stand fast? Your Lord is always watching

Qur'ān 25:7English sense: eat | Arabic sense: الطعام, طعام

وَقَالُواْ مَالِ هَٰذَا ٱلرَّسُولِ يَأۡكُلُ ٱلطَّعَامَ وَيَمۡشِي فِي ٱلۡأَسۡوَاقِ لَوۡلَآ أُنزِلَ إِلَيۡهِ مَلَكࣱ فَيَكُونَ مَعَهُۥ نَذِيرًا

They also say, ‘What sort of messenger is this? He eats food and walks about in the marketplaces! Why has no angel been sent down to help him with his warnings

Qur'ān 2:57English sense: eat | Arabic sense: كلوا

وَظَلَّلۡنَا عَلَيۡكُمُ ٱلۡغَمَامَ وَأَنزَلۡنَا عَلَيۡكُمُ ٱلۡمَنَّ وَٱلسَّلۡوَىٰۖ كُلُواْ مِن طَيِّبَٰتِ مَا رَزَقۡنَٰكُمۡۚ وَمَا ظَلَمُونَا وَلَٰكِن كَانُوٓاْ أَنفُسَهُمۡ يَظۡلِمُونَ

We made the clouds cover you with shade, and sent manna and quails down to you, saying, ‘Eat the good things We have provided for you.’ It was not Us they wronged; they wronged themselves

Tafsīr

التفسير6 shown

Commentary on the verses above, at most two editions per verse.

en-asbab-al-nuzul-by-al-wahidi on 7:31en-asbab-al-nuzul-by-al-wahidicommentary on an ayah this subject surfaced

O children of Adam! Put on your adornment at every place of prostration. In the tongue of learning, this is the curtaining of the pudendum during the prayer. In the tongue of unveiling, the adornment of every servant is in the station of contemplating the heart's presence, clinging to the Presence, and the continuity of witnessing the Haqiqah. It has been said that the adornment of the worshiper's soul is the traces of prostration, and the adornment of the recognizer's heart is the lights of finding. The worshiper has the attribute of servanthood in the prostration, and the recognizer is on the carpet of proximity in the repose of witnessing.

en-al-jalalayn on 6:141en-al-jalalayncommentary on an ayah this subject surfaced

And He it is Who produces creates gardens orchards trellised extending along the ground as in the case of watermelons and untrellised rising upwards on a stem such as palm-trees; and He produces palm-trees and crops diverse in flavour diverse in the shape and savour of its fruit and seed and olives and pomegranates alike in terms of their leaf mutashābihan ‘alike’ is a circumstantial qualifier and unlike in terms of their savour. Eat of the fruit thereof when it ripens before its maturity passes and pay the due thereof the alms as appropriate on the day of its harvest read yawma hasādahu or yawma hasādihi that is one tenth or half of it and do not be prodigal by giving it all away so that nothing remains for the consumption of your dependants. Truly God does not love the prodigal who overstep the bounds of that which He has delimited for them.

en-al-jalalayn on 7:31en-al-jalalayncommentary on an ayah this subject surfaced

O Children of Adam! Don your adornment that which covers your nakedness at every place of worship at prayer and at the circumambulation and eat and drink what you want but do not be excessive; He truly does not love those who are excessive.

en-tafisr-ibn-kathir on 6:141en-tafisr-ibn-kathircommentary on an ayah this subject surfaced

And it is He Who produces gardens Ma'rushat and not Ma'rushat, and date palms, and crops of different shape and taste, and olives, and pomegranates, similar, and different. Eat of their fruit when they ripen, but pay the due thereof on the day of their harvest, and waste not by extravagance. Verily, He likes not the wasteful (141)And of the cattle (are some) for burden and (some smaller) for Farsh. Eat of what Allah has provided for you, and follow not the footsteps of Shaytan. Surely, he is to you an open enemy (142) Allah Created the Produce, Seed Grains and Cattle Allah states that He created everything, including the produce, fruits and cattle that the idolators mishandled by their misguided ideas, dividing them into various designated parts, allowing some and prohibiting some. Allah said, وَهُوَ الَّذِي أَنشَأَ جَنَّاتٍ مَّعْرُوشَاتٍ وَغَيْرَ مَعْرُوشَاتٍ (And it is He Who produ

en-al-jalalayn on 5:88en-al-jalalayncommentary on an ayah this subject surfaced

And eat of the lawful and good food which God has provided you halālan tayyiban ‘lawful and good food’ is the direct object and the preceding genitive construction mimmā ‘of … which’ is a circumstantial qualifier connected to the former; and fear God in Whom you are believers.

en-tafisr-ibn-kathir on 5:88en-tafisr-ibn-kathircommentary on an ayah this subject surfaced

O you who believe! Make not unlawful the good things which Allah has made lawful to you, and transgress not. Verily, Allah does not like the transgressors (87)And eat of the things which Allah has provided for you, lawful and good, and have Taqwa of Allah in Whom you believe (88) There is No Monasticism in Islam Ali bin Abi Talhah said that Ibn 'Abbas said, "This Ayah [5:87] was revealed about some of the Companions of the Prophet ﷺ who said, 'We should cut off our male organs, abandon the desires of this life and travel in the land, just as the Ruhban (monks) do.' When the Prophet ﷺ heard of this statement, he summoned them and asked them if they made this statement and they answered 'Yes.' The Prophet ﷺ said, لٰكِنِّي أَصُومُ وَأُفْطِرُ، وَأُصَلِّي، وَأَنَامُ، وَأَنْكِحُ النِّسَاءَ، فَمَنْ أَخَذَ بِسُنَّتِي فَهُوَ مِنِّي، وَمَنْ لَمْ يَأْخُذْ بِسُنَّتِي فَلَيْسَ مِنِّي (I fast and

Ḥadīth

الحديث6 shown

Sound narrations only, and never matched by text. A narration appears here because a compiler filed it under a chapter this subject maps to, or because someone read it and anchored it. Each row says which.

Sahih al-Bukhari 5467Sacrifice On Occasion Of Birthfiled here by the compiler

حَدَّثَنِي إِسْحَاقُ بْنُ نَصْرٍ، حَدَّثَنَا أَبُو أُسَامَةَ، قَالَ حَدَّثَنِي بُرَيْدٌ، عَنْ أَبِي بُرْدَةَ، عَنْ أَبِي مُوسَى ـ رضى الله عنه ـ قَالَ وُلِدَ لِي غُلاَمٌ، فَأَتَيْتُ بِهِ النَّبِيَّ صلى الله عليه وسلم فَسَمَّاهُ إِبْرَاهِيمَ، فَحَنَّكَهُ بِتَمْرَةٍ، وَدَعَا لَهُ بِالْبَرَكَةِ وَدَفَعَهُ إِلَىَّ، وَكَانَ أَكْبَرَ وَلَدِ أَبِي مُوسَى‏.‏

Narrated Abu Musa:A son was born to me and I took him to the Prophet (ﷺ) who named him Ibrahim, did Tahnik for him with a date, invoked Allah to bless him and returned him to me. (The narrator added: That was Abu Musa's eldest son)

Sahih al-Bukhari 5468Sacrifice On Occasion Of Birthfiled here by the compiler

حَدَّثَنَا مُسَدَّدٌ، حَدَّثَنَا يَحْيَى، عَنْ هِشَامٍ، عَنْ أَبِيهِ، عَنْ عَائِشَةَ ـ رضى الله عنها ـ قَالَتْ أُتِيَ النَّبِيُّ صلى الله عليه وسلم بِصَبِيٍّ يُحَنِّكُهُ، فَبَالَ عَلَيْهِ، فَأَتْبَعَهُ الْمَاءَ‏.‏

Narrated `Aisha:A boy was brought to the Prophet (ﷺ) to do Tahnik for him, but the boy urinated on him, whereupon the Prophet had water poured on the place of urine

Jami' at-Tirmidhi 1494The Book On Sacrificesfiled here by the compiler

حَدَّثَنَا قُتَيْبَةُ، حَدَّثَنَا أَبُو عَوَانَةَ، عَنْ قَتَادَةَ، عَنْ أَنَسِ بْنِ مَالِكٍ، قَالَ ضَحَّى رَسُولُ اللَّهِ صلى الله عليه وسلم بِكَبْشَيْنِ أَمْلَحَيْنِ أَقْرَنَيْنِ ذَبَحَهُمَا بِيَدِهِ وَسَمَّى وَكَبَّرَ وَوَضَعَ رِجْلَهُ عَلَى صِفَاحِهِمَا ‏.‏ قَالَ وَفِي الْبَابِ عَنْ عَلِيٍّ وَعَائِشَةَ وَأَبِي هُرَيْرَةَ وَأَبِي أَيُّوبَ وَجَابِرٍ وَأَبِي الدَّرْدَاءِ وَأَبِي رَافِعٍ وَابْنِ عُمَرَ وَأَبِي بَكْرَةَ أَيْضًا ‏.‏ قَالَ أَبُو عِيسَى هَذَا حَدِيثٌ حَسَنٌ صَحِيحٌ ‏.‏

Narrated Anas bin Malik:"The Messenger of Allah (ﷺ) slaughtered two horned male sheep which were mostly white. He slaughtered them with his hand and mentioned Allah's Name, and he said 'Allahu Akbar', and put his foot on their side

Jami' at-Tirmidhi 1496The Book On Sacrificesfiled here by the compiler

حَدَّثَنَا أَبُو سَعِيدٍ الأَشَجُّ، حَدَّثَنَا حَفْصُ بْنُ غِيَاثٍ، عَنْ جَعْفَرِ بْنِ مُحَمَّدٍ، عَنْ أَبِيهِ، عَنْ أَبِي سَعِيدٍ الْخُدْرِيِّ، قَالَ ضَحَّى رَسُولُ اللَّهِ صلى الله عليه وسلم بِكَبْشٍ أَقْرَنَ فَحِيلٍ يَأْكُلُ فِي سَوَادٍ وَيَمْشِي فِي سَوَادٍ وَيَنْظُرُ فِي سَوَادٍ ‏.‏ قَالَ أَبُو عِيسَى هَذَا حَدِيثٌ حَسَنٌ صَحِيحٌ غَرِيبٌ لاَ نَعْرِفُهُ إِلاَّ مِنْ حَدِيثِ حَفْصِ بْنِ غِيَاثٍ ‏.‏

Narrated Abu Sa'eed Al-Khudri:"The Messenger of Allah (ﷺ) slaughtered a horned male ram of fine pedigree, (around) his mouth was black, and his legs were black, and (around) his eyes was black

Jami' at-Tirmidhi 1464The Book On Huntingfiled here by the compiler

حَدَّثَنَا أَحْمَدُ بْنُ مَنِيعٍ، حَدَّثَنَا يَزِيدُ بْنُ هَارُونَ، حَدَّثَنَا الْحَجَّاجُ، عَنْ مَكْحُولٍ، عَنْ أَبِي ثَعْلَبَةَ، وَالْحَجَّاجُ، عَنِ الْوَلِيدِ بْنِ أَبِي مَالِكٍ، عَنْ عَائِذِ اللَّهِ بْنِ عَبْدِ اللَّهِ، أَنَّهُ سَمِعَ أَبَا ثَعْلَبَةَ الْخُشَنِيَّ، قَالَ قُلْتُ يَا رَسُولَ اللَّهِ إِنَّا أَهْلُ صَيْدٍ ‏.‏ قَالَ ‏"‏ إِذَا أَرْسَلْتَ كَلْبَكَ وَذَكَرْتَ اسْمَ اللَّهِ عَلَيْهِ فَأَمْسَكَ عَلَيْكَ فَكُلْ ‏"‏ ‏.‏ قُلْتُ وَإِنْ قَتَلَ قَالَ ‏"‏ وَإِنْ قَتَلَ ‏"‏ ‏.‏ قُلْتُ إِنَّا أَهْلُ رَمْىٍ ‏.‏ قَالَ ‏"‏ مَا رَدَّتْ عَلَيْكَ قَوْسُكَ فَكُلْ ‏"‏ ‏.‏ قَالَ قُلْتُ إِنَّا أَهْلُ سَفَرٍ نَمُرُّ بِالْيَهُودِ وَالنَّصَارَى وَالْمَجُوسِ فَلاَ نَجِدُ غَيْرَ آنِيَتِهِمْ ‏.‏ قَالَ ‏"‏ فَإِنْ لَمْ تَجِدُوا غَيْرَهَا فَاغْسِلُوهَا بِالْمَاءِ ثُمَّ كُلُوا فِيهَا وَاشْرَبُوا ‏"‏ ‏.‏ قَالَ وَفِي الْبَابِ عَنْ عَدِيِّ بْنِ حَاتِمٍ ‏.‏ قَالَ أَبُو عِيسَى هَذَا حَدِيثٌ حَسَنٌ صَحِيحٌ ‏.‏ وَعَائِذُ اللَّهِ بْنُ عَبْدِ اللَّهِ هُوَ أَبُو إِدْرِيسَ الْخَوْلاَنِيُّ وَاسْمُ أَبِي ثَعْلَبَةَ الْخُشَنِيِّ جُرْثُومٌ وَيُقَالُ جُرْثُمُ بْنُ نَاشِرٍ وَيُقَالُ ابْنُ قَيْسٍ ‏.‏

Narrated Abu Tha'labah Al-Khushani:"I said: 'O Messenger of Allah! We are a people who hunt.' He said: 'If you send your dog and you mentioned the Name of Allah upon it, and he catches something for you, then eat it.' I said: 'Even if he kills it?' He said: 'Even if he kills it.' I said: 'We are a people who shoot (at game).' He said: 'What you catch with your bow, then eat it.'" He said: "Then I said:'Indeed we are a people who travel. We come across Jews, Christians, and Zoroastrians, and we do not find vessels other than theirs.' He said: 'If you do not find other than them, then wash them with water, then eat and drink from it

Classical works

كتب التراث6 shown

Arabic originals, reached through the subject’s Arabic senses. Interpretive sources, never proof of a ruling.

ihya §13812ihyaArabic sense: الشبع, الطعام, شبع, طعام

والميل إذا لم يكن لا يمكن اختراعه واكتسابه بمجرد الإرادة بل ذلك كقول الشبعان نويت أن أشتهى الطعام وأميل إليه أو قول الفارغ نويت أن أعشق فلانا وأحبه وأعظمه بقلبى فذلك محال

ihya §3255ihyaArabic sense: الشبع, الطعام, شبع, طعام

ثم ينبغي أن يرفع اليد قبل الشبع ومن فعل ذلك استغنى عن الطبيب وسيأتي فائدة قلة الأكل وكيفية التدريج في التقليل منه في كتاب كسر شهوة الطعام من ربع المهلكات

mukhtasar-minhaj §2476mukhtasar-minhajArabic sense: الشبع, الطعام, شبع, طعام

ثم إن الشهوة لو لم تسكن عند أخذ مقدار الحاجة من الطعام، لأسرفت وأهلكت نفسك، فخلق لك الكراهة عند الشبع لتترك الأكل بها، وكذلك القول في شهوة الوقاع لحكمة بقاء النسل.

mukhtasar-minhaj §554mukhtasar-minhajArabic sense: الطعام, طعام, كلوا

وكان خيثمى رحمه الله يصنع الخبيص والطعام الطيب، فيدعو إبراهيم والأعمش ويقول: كلوا، فما صنعته إلا لكم.

riyad-salihin §949riyad-salihinArabic sense: الطعام, طعام, كلوا

744 عن ابن عباس رضي الله عنهما عن النبي صلى الله عليه وسلم قال البركة تنزل وسط الطعام فكلوا من حافتيه ولا تأكلوا من وسطه رواه أبو داود والترمذي وقال حديث حسن صحيح

mukhtasar-minhaj §537mukhtasar-minhajArabic sense: الشبع, الطعام, شبع

ومن ضرورة هذه النية أن لا يمد يده إلى الطعام إلا وهو جائع، وأن يرفع يده قبل الشبع، ومع فعل ذلك لم يكد يحتاج إلى طبيب، ومن ذلك أن يرضى بالموجود من الرزق، ولا يحتقر اليسير منه، وأن يجتهد فى تكثير الأيدى على الطعام ولو من أهله وولده.

Research library

المكتبة البحثية1,410 works held

Peer-reviewed work held with its DOI and abstract, labelled with the study design its publication types report. None of it has been read or assessed, so nothing here may be cited as showing anything. Retracted work is held for the record but never listed; a review that a later version replaced is listed under its replacement and marked.

10.1186/1475-2891-4-9Nutrition journal (2005)MEDLINE-indexed journal, not yet read by us; matched on Diet, Feeding Behavior, Dietary Carbohydrates, Dietary Fats, Energy Intake, Fruit, Vegetables, nutrition

Food selection associated with sense of coherence in adults.: Background: Favorable dietary habits promote health, whereas unfavorable habits link to various chronic diseases. An individual's "sense of coherence" (SOC) is reported to correlate with prevalence of some diseases to which dietary habits are linked. However, understanding what determines an individual's dietary preferences and how to change his/her behavior remains limited. The aim of the present study was to evaluate associations between dietary intake and SOC in adults. Methods: Diet intake w

10.1016/j.nut.2019.110640Nutrition (Burbank, Los Angeles County, Calif.) (2020)MEDLINE-indexed journal, not yet read by us; matched on Diet, Nutritional Status, Feeding Behavior, Nutritional Status, Energy Intake, nutrition

Malnutrition in older adults: Correlations with social, diet-related, and neuropsychological factors.: Background: The number of older adults is increasing rapidly. Malnutrition is a major problem in this age group, which may adversely affect health and quality of life. Several physiological, socioeconomic, and neuropsychological factors can lead to malnutrition. Objectives: The aim of this study was to evaluate the nutritional status of community-dwelling older adults, and explore the associations of malnutrition risk with physiological, socioeconomic, and neuropsychological characteristics. Met

10.3390/nu11040825Nutrients (2019)MEDLINE-indexed journal, not yet read by us; matched on Diet, Feeding Behavior, Diet, Healthy, Dietary Fats, Energy Intake, Fruit, Vegetables

Effectiveness of Interventions and Behaviour Change Techniques for Improving Dietary Intake in Young Adults: A Systematic Review and Meta-Analysis of RCTs.: Poor eating habits are common during young adulthood and influence chronic disease morbidity. This systematic review evaluates the effectiveness of interventions aiming to improve dietary intake among young adults and, identifies which behaviour change techniques (BCTs) are most effective. Six electronic databases were searched for RCTs published until October 2018, and evaluating behavioural interventions assessing change in dietary intake in young adults (17-35 years). Of the 18,779 articles i

10.1016/j.arr.2021.101403Ageing research reviews (2021)MEDLINE-indexed journal, not yet read by us; matched on Diet, Diet, Mediterranean, dietary pattern, Fruit, Vegetables, nutrition

Associations between nutrition and the incidence of depression in middle-aged and older adults: A systematic review and meta-analysis of prospective observational population-based studies.: Aim: To systematically examine the longitudinal observational evidence between diet and the incidence of depression in adults aged 45 years and older. Method: Three electronic databases were searched for cohort studies published up to December 2020 that investigated the association between baseline dietary intake and incidence of depression in community-dwelling adults aged 45+years. Combined odds ratios (OR) and 95% confidence intervals (95%CI) were calculated. Random-effects models were used.

10.1016/j.maturitas.2014.06.014Maturitas (2014)MEDLINE-indexed journal, not yet read by us; matched on Diet, Diet, Mediterranean, Feeding Behavior, dietary pattern

Dietary patterns and stroke: a systematic review and re-meta-analysis.: The effect of diet on the development of stroke has recently achieved much interest by various research groups, but with inconclusive results. The aim of the present review was to systematically present and discuss the up to date available research regarding the relationship between adherence to dietary patterns and stroke. Studies included were observational and randomized clinical trials. Internet searches until May 31, 2014, retrieved 152 potentially relevant papers; of them, 34 were excluded

10.1093/advances/nmz117Advances in nutrition (Bethesda, Md.) (2020)MEDLINE-indexed journal, not yet read by us; matched on Diet, Diet, Mediterranean, dietary pattern, Vegetables, nutrition

Effects of Polyphenols in a Mediterranean Diet on Symptoms of Depression: A Systematic Literature Review.: Depression is a mood disorder which currently affects 350 million individuals worldwide. Recently, research has suggested a protective role of diet for depression. The Mediterranean-style dietary pattern has been highlighted in several systematic reviews as a promising candidate for reducing depressive symptoms. It has been speculated that this could be due to the high polyphenol content of foods commonly found in the diet. Therefore, the aim of this review was to assess the effects of polypheno

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701 to 725 of 1,410
Widmer RJ, Flammer AJ, Lerman LO, Lerman A (2015)reviewMEDLINE-indexed journal, not yet read by usThe American journal of medicine570 citations

The Mediterranean diet, its components, and cardiovascular disease.

One of the best-studied diets for cardiovascular health is the Mediterranean diet. This consists of fish, monounsaturated fats from olive oil, fruits, vegetables, whole grains, legumes/nuts, and moderate alcohol consumption. The Mediterranean diet has been shown to reduce the burden, or even prevent the development, of cardiovascular disease, breast cancer, depression, colorectal cancer, diabetes, obesity, asthma, erectile dysfunction, and cognitive decline. This diet is also known to improve surrogates of cardiovascular disease, such as waist-to-hip ratio, lipids, and markers of inflammation, as well as primary cardiovascular disease outcomes such as death and events in both observational and randomized controlled trial data. These enhancements easily rival those seen with more established tools used to fight cardiovascular disease such as aspirin, beta-blockers, angiotensin-converting

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Galay RL, Umemiya-Shirafuji R, Mochizuki M, Fujisaki K, Tanaka T (2015)reviewMEDLINE-indexed journal, not yet read by usParasitology international46 citations

Iron metabolism in hard ticks (Acari: Ixodidae): the antidote to their toxic diet.

Ticks are notorious parasitic arthropods, known for their completely host-blood-dependent lifestyle. Hard ticks (Acari: Ixodidae) feed on their hosts for several days and can ingest blood more than a hundred times their unfed weight. Their blood-feeding habit facilitates the transmission of various pathogens. It is remarkable how hard ticks cope with the toxic nature of their blood meal, which contains several molecules that can promote oxidative stress including iron. While it is required in several physiological processes, high amounts of iron can be dangerous because iron can also participate in the formation of free radicals that may cause cellular damage and death. Here we review the current knowledge on heme and inorganic iron metabolism in hard ticks and compare it with that in vertebrates and other arthropods. We briefly discuss the studies on heme transport, storage and detoxifi

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Mayer EA, Tillisch K, Gupta A (2015)reviewMEDLINE-indexed journal, not yet read by usThe Journal of clinical investigation1,024 citations

Gut/brain axis and the microbiota.

Tremendous progress has been made in characterizing the bidirectional interactions between the central nervous system, the enteric nervous system, and the gastrointestinal tract. A series of provocative preclinical studies have suggested a prominent role for the gut microbiota in these gut-brain interactions. Based on studies using rodents raised in a germ-free environment, the gut microbiota appears to influence the development of emotional behavior, stress- and pain-modulation systems, and brain neurotransmitter systems. Additionally, microbiota perturbations by probiotics and antibiotics exert modulatory effects on some of these measures in adult animals. Current evidence suggests that multiple mechanisms, including endocrine and neurocrine pathways, may be involved in gut microbiota-to-brain signaling and that the brain can in turn alter microbial composition and behavior via the aut

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Spiller RC (2015)reviewMEDLINE-indexed journal, not yet read by usNeurogastroenterology and motility36 citations

Changing views on diverticular disease: impact of aging, obesity, diet, and microbiota.

The development of colonic diverticulosis is a common aging change in industrialized nations. While most patients have asymptomatic diverticulosis, around one in five develops symptomatic diverticular disease. This is characterized by recurrent abdominal pain and disturbed bowel habit. Some of the pain episodes are prolonged and are due to acute diverticulitis, which itself may be complicated by abscess, perforation, fistulation, or stricture formation. Risk factors favouring the development of symptomatic diverticular disease include obesity, smoking and diets low in fiber but high in red meat and animal fat. What determines the transition from asymptomatic diverticulosis to symptomatic diverticular disease is unclear but neuromuscular changes following acute diverticulitis may be responsible in some cases. The severity of symptoms generated depends on cerebral pain processing which is

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Mulak A, Bonaz B (2015)reviewMEDLINE-indexed journal, not yet read by usWorld journal of gastroenterology427 citations

Brain-gut-microbiota axis in Parkinson's disease.

Parkinson's disease (PD) is characterized by alpha-synucleinopathy that affects all levels of the brain-gut axis including the central, autonomic, and enteric nervous systems. Recently, it has been recognized that the brain-gut axis interactions are significantly modulated by the gut microbiota via immunological, neuroendocrine, and direct neural mechanisms. Dysregulation of the brain-gut-microbiota axis in PD may be associated with gastrointestinal manifestations frequently preceding motor symptoms, as well as with the pathogenesis of PD itself, supporting the hypothesis that the pathological process is spread from the gut to the brain. Excessive stimulation of the innate immune system resulting from gut dysbiosis and/or small intestinal bacterial overgrowth and increased intestinal permeability may induce systemic inflammation, while activation of enteric neurons and enteric glial cell

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Dash S, Clarke G, Berk M, Jacka FN (2015)reviewMEDLINE-indexed journal, not yet read by usCurrent opinion in psychiatry238 citations

The gut microbiome and diet in psychiatry: focus on depression.

Purpose of review: With depressive disorders the leading source of disability globally, the identification of new targets for prevention and management is imperative. A rapidly emerging field of research suggests that the microbiome-gut-brain axis is of substantial relevance to mood and behaviour. Similarly, unhealthy diet has recently emerged as a significant correlate of and risk factor for depression. This review provides evidence for the gut microbiota as a key factor mediating the link between diet and depressive illness. Recent findings: The development of new technologies is affording a better understanding of how diet influences gut microbiota composition and activity and how this may, in turn, influence depressive illness. New interventions are also suggesting the possible utility of pre and probiotic formulations and fermented food in influencing mental health. Summary: Althoug

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Grosso G, Galvano F, Marventano S, Malaguarnera M, Bucolo C, Drago F, Caraci F (2014)reviewMEDLINE-indexed journal, not yet read by usOxidative medicine and cellular longevity204 citations

Omega-3 fatty acids and depression: scientific evidence and biological mechanisms.

The changing of omega-6/omega-3 polyunsaturated fatty acids (PUFA) in the food supply of Western societies occurred over the last 150 years is thought to promote the pathogenesis of many inflammatory-related diseases, including depressive disorders. Several epidemiological studies reported a significant inverse correlation between intake of oily fish and depression or bipolar disorders. Studies conducted specifically on the association between omega-3 intake and depression reported contrasting results, suggesting that the preventive role of omega-3 PUFA may depend also on other factors, such as overall diet quality and the social environment. Accordingly, tertiary prevention with omega-3 PUFA supplement in depressed patients has reached greater effectiveness during the last recent years, although definitive statements on their use in depression therapy cannot be yet freely asserted. Amon

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Holt RI, de Groot M, Golden SH (2014)reviewMEDLINE-indexed journal, not yet read by usCurrent diabetes reports301 citations

Diabetes and depression.

Diabetes and depression occur together approximately twice as frequently as would be predicted by chance alone. Comorbid diabetes and depression are a major clinical challenge as the outcomes of both conditions are worsened by the other. Although the psychological burden of diabetes may contribute to depression, this explanation does not fully explain the relationship between these 2 conditions. Both conditions may be driven by shared underlying biological and behavioral mechanisms, such as hypothalamic-pituitary-adrenal axis activation, inflammation, sleep disturbance, inactive lifestyle, poor dietary habits, and environmental and cultural risk factors. Depression is frequently missed in people with diabetes despite effective screening tools being available. Both psychological interventions and antidepressants are effective in treating depressive symptoms in people with diabetes but hav

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Samuel LJ, Commodore-Mensah Y, Himmelfarb CR (2014)reviewMEDLINE-indexed journal, not yet read by usHealth education & behavior : the official publication of the Society for Public Health Education28 citations

Developing Behavioral Theory With the Systematic Integration of Community Social Capital Concepts.

Health behavior theories state that social environments influence health behaviors, but theories of how this occurs are relatively underdeveloped. This article systematically surveys community social capital concepts in health behavior literature and proposes a conceptual framework that integrates these concepts into existing behavioral theory. Fifty-three studies tested associations between community social capital concepts and physical activity (38 studies), smoking (19 studies), and diet (2 studies). Trustworthiness of community members was consistently associated with more health-promoting and less disease-promoting behaviors in 19 studies. Neighborly reciprocity showed mixed results in 10 studies. Reporting a good sense of community was associated with more physical activity in only 5 of 16 studies. Neighborhood collective efficacy, which includes social cohesion and informal social

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Sarris J, O'Neil A, Coulson CE, Schweitzer I, Berk M (2014)reviewMEDLINE-indexed journal, not yet read by usBMC psychiatry248 citations

Lifestyle medicine for depression.

The prevalence of depression appears to have increased over the past three decades. While this may be an artefact of diagnostic practices, it is likely that there are factors about modernity that are contributing to this rise. There is now compelling evidence that a range of lifestyle factors are involved in the pathogenesis of depression. Many of these factors can potentially be modified, yet they receive little consideration in the contemporary treatment of depression, where medication and psychological intervention remain the first line treatments. "Lifestyle Medicine" provides a nexus between public health promotion and clinical treatments, involving the application of environmental, behavioural, and psychological principles to enhance physical and mental wellbeing. This may also provide opportunities for general health promotion and potential prevention of depression. In this paper

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Finsterer J, Mahjoub SZ (2014)reviewMEDLINE-indexed journal, not yet read by usThe American journal of hospice & palliative care222 citations

Fatigue in healthy and diseased individuals.

Objectives: Although fatigue is experienced by everyone, its definition and classification remains under debate. Methods: A review of the previously published data on fatigue. Results: Fatigue is influenced by age, gender, physical condition, type of food, latency to last meal, mental status, psychological conditions, personality type, life experience, and the health status of an individual. Fatigue may not only be a symptom but also a measurable and quantifiable dimension, also known as fatigability. Additionally, it may be classified as a condition occurring at rest or under exercise or stress, as physiologic reaction or pathologic condition, as spontaneous phenomenon or triggerable state, as resistant or irresistant to preconditioning, training, or attitude, as prominent or collateral experience, and as accessible or inaccessible to any type of treatment or intervention. Fatigue may b

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Hemmingsson E (2014)reviewMEDLINE-indexed journal, not yet read by usObesity reviews : an official journal of the International Association for the Study of Obesity143 citations

A new model of the role of psychological and emotional distress in promoting obesity: conceptual review with implications for treatment and prevention.

The lack of significant treatment and prevention progress highlights the need for a more expanded strategy. Given the robust association between socioeconomic factors and obesity, combined with new insights into how socioeconomic disadvantage affects both behaviour and biology, a new causal model is proposed. The model posits that psychological and emotional distress is a fundamental link between socioeconomic disadvantage and weight gain. At particular risk are children growing up in a disharmonious family environment, mainly caused by parental socioeconomic disadvantage, where they are exposed to parental frustrations, relationship discord, a lack of support and cohesion, negative belief systems, unmet emotional needs and general insecurity. Without adequate resilience, such experiences increase the risk of psychological and emotional distress, including low self-esteem and self-worth,

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Lopresti AL, Hood SD, Drummond PD (2013)reviewMEDLINE-indexed journal, not yet read by usJournal of affective disorders443 citations

A review of lifestyle factors that contribute to important pathways associated with major depression: diet, sleep and exercise.

Research on major depression has confirmed that it is caused by an array of biopsychosocial and lifestyle factors. Diet, exercise and sleep are three such influences that play a significant mediating role in the development, progression and treatment of this condition. This review summarises animal- and human-based studies on the relationship between these three lifestyle factors and major depressive disorder, and their influence on dysregulated pathways associated with depression: namely neurotransmitter processes, immuno-inflammatory pathways, hypothalamic-pituitary-adrenal (HPA) axis disturbances, oxidative stress and antioxidant defence systems, neuroprogression, and mitochondrial disturbances. Increased attention in future clinical studies on the influence of diet, sleep and exercise on major depressive disorder and investigations of their effect on physiological processes will help

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Lee JH, Khor TO, Shu L, Su ZY, Fuentes F, Kong AN (2013)reviewMEDLINE-indexed journal, not yet read by usPharmacology & therapeutics160 citations

Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression.

Reactive metabolites from carcinogens and oxidative stress can drive genetic mutations, genomic instability, neoplastic transformation, and ultimately carcinogenesis. Numerous dietary phytochemicals in vegetables/fruits have been shown to possess cancer chemopreventive effects in both preclinical animal models and human epidemiological studies. These phytochemicals could prevent the initiation of carcinogenesis via either direct scavenging of reactive oxygen species/reactive nitrogen species (ROS/RNS) or, more importantly, the induction of cellular defense detoxifying/antioxidant enzymes. These defense enzymes mediated by Nrf2-antioxidative stress and anti-inflammatory signaling pathways can contribute to cellular protection against ROS/RNS and reactive metabolites of carcinogens. In addition, these compounds would kill initiated/transformed cancer cells in vitro and in in vivo xenograft

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Ananthakrishnan AN (2013)reviewMEDLINE-indexed journal, not yet read by usCurrent gastroenterology reports87 citations

Environmental triggers for inflammatory bowel disease.

Inflammatory bowel diseases [IBD; Crohn's disease (CD), ulcerative colitis (UC)] are chronic immunologically mediated diseases that are due to a dysregulated immune response to intestinal flora in a genetically susceptible host. Despite advances in genetics, the likelihood of occurrence of disease remains incompletely explained and there appears to be a strong role for the environment in mediating risk of disease. Smoking remains the most widely studied and replicated risk factor, contributing to increased risk and severity of CD while conferring protection against UC. Recent data has suggested novel risk factors. Lower plasma vitamin D is associated with an increased risk of Crohn's disease, and vitamin D supplementation may prevent relapse of disease. Several medications including oral contraceptives, post-menopausal hormone replacement, aspirin, NSAIDs, and antibiotics may increase ri

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Marín C, Yubero-Serrano EM, López-Miranda J, Pérez-Jiménez F, Pérez-Jiménez F (2013)reviewMEDLINE-indexed journal, not yet read by usInternational journal of molecular sciences65 citations

Endothelial aging associated with oxidative stress can be modulated by a healthy mediterranean diet.

Aging is a condition which favors the development of atherosclerosis, which has been associated with a breakdown in repair processes that occurs in response to cell damage. The dysregulation of the biological systems associated with aging are produced partly through damage which accumulates over time. One major source of this injury is oxidative stress, which can impair biological structures and the mechanisms by which they are repaired. These mechanisms are based on the pathogenesis of endothelial dysfunction, which in turn is associated with cardiovascular disease, carcinogenesis and aging. The dependent dysfunction of aging has been correlated with a reduction in the number and/or functional activity of endothelial progenitor cells, which could hinder the repair and regeneration of the endothelium. In addition, aging, inflammation and oxidative stress are endogenous factors that cause

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Fyhrquist F, Saijonmaa O (2012)reviewMEDLINE-indexed journal, not yet read by usAnnals of medicine70 citations

Telomere length and cardiovascular aging.

Telomeres are located at the end of chromosomes. They are composed of repetitive TTAGGG tandem repeats and associated proteins of crucial importance for telomere function. Telomeric DNA is shortened by each cell division until a critical length is achieved and the cell enters senescence and eventually apoptosis. Telomeres are therefore considered a 'biological clock' of the cell. Telomerase adds nucleotides to telomeric DNA thereby contributing to telomere maintenance, genomic stability, functions, and proliferative capacity of the cell. In certain rare forms of progeria, point mutations within the telomere lead to accelerated telomere attrition and premature aging. Endogenous factors causing telomere shortening are aging, inflammation, and oxidative stress. Leukocyte telomere length (LTL) shortening is inhibited by estrogen and endogenous antioxidants. Accelerated telomere attrition is

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Mathus-Vliegen EM, Obesity Management Task Force of the European Association for the Study of Obesity (2012)reviewMEDLINE-indexed journal, not yet read by usObesity facts139 citations

Prevalence, pathophysiology, health consequences and treatment options of obesity in the elderly: a guideline.

The prevalence of obesity is rising progressively, even among older age groups. By the year 2030-2035 over 20% of the adult US population and over 25% of the Europeans will be aged 65 years and older. The predicted prevalence of obesity in Americans, 60 years and older was 37% in 2010. The predicted prevalence of obesity in Europe in 2015 varies between 20 and 30% dependent on the model used. This means 20.9 million obese 60+ people in the USA in 2010 and 32 million obese elders in 2015 in the EU. Although cut-off values of BMI, waist circumference and percentages of fat mass have not been defined for the elderly (nor for the elderly of different ethnicity), it is clear from several meta-analyses that mortality and morbidity associated with overweight and obesity only increases at a BMI above 30 kg/m(2). Thus, treatment should only be offered to patients who are obese rather than overwei

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Dias GP, Cavegn N, Nix A, do Nascimento Bevilaqua MC, Stangl D, Zainuddin MS, Nardi AE, Gardino PF, Thuret S (2012)reviewMEDLINE-indexed journal, not yet read by usOxidative medicine and cellular longevity104 citations

The role of dietary polyphenols on adult hippocampal neurogenesis: molecular mechanisms and behavioural effects on depression and anxiety.

Although it has been long believed that new neurons were only generated during development, there is now growing evidence indicating that at least two regions in the brain are capable of continuously generating functional neurons: the subventricular zone and the dentate gyrus of the hippocampus. Adult hippocampal neurogenesis (AHN) is a widely observed phenomenon verified in different adult mammalian species including humans. Factors such as environmental enrichment, voluntary exercise, and diet have been linked to increased levels of AHN. Conversely, aging, stress, anxiety and depression have been suggested to hinder it. However, the mechanisms underlying these effects are still unclear and yet to be determined. In this paper, we discuss some recent findings addressing the effects of different dietary polyphenols on hippocampal cell proliferation and differentiation, models of anxiety,

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Liu J, Davidson E, Bhopal R, White M, Johnson M, Netto G, Deverill M, Sheikh A (2012)reviewMEDLINE-indexed journal, not yet read by usHealth technology assessment (Winchester, England)142 citations

Adapting health promotion interventions to meet the needs of ethnic minority groups: mixed-methods evidence synthesis.

Background: There is now a considerable body of evidence revealing that a number of ethnic minority groups in the UK and other economically developed countries experience disproportionate levels of morbidity and mortality compared with the majority white European-origin population. Across these countries, health-promoting approaches are increasingly viewed as the long-term strategies most likely to prove clinically effective and cost-effective for preventing disease and improving health outcomes in those with established disease. Objectives: To identify, appraise and interpret research on the approaches employed to maximise the cross-cultural appropriateness and effectiveness of health promotion interventions for smoking cessation, increasing physical activity and improving healthy eating for African-, Chinese- and South Asian-origin populations. Data sources: Two national conferences; s

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Hills AP, Andersen LB, Byrne NM (2011)reviewMEDLINE-indexed journal, not yet read by usBritish journal of sports medicine333 citations

Physical activity and obesity in children.

Globally, obesity is affecting an increasing proportion of children. Physical activity plays an important role in the prevention of becoming overweight and obese in childhood and adolescence, and reducing the risk of obesity in adulthood. Puberty and the following adolescent period are acknowledged as particularly vulnerable times for the development of obesity due to sexual maturation and, in many individuals, a concomitant reduction in physical activity. In many Western settings, a large proportion of children and adolescents do not meet recommended physical activity guidelines and, typically, those who are more physically active have lower levels of body fat than those who are less active. Active behaviours have been displaced by more sedentary pursuits which have contributed to reductions in physical activity energy expenditure. Without appropriate activity engagement there is an inc

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Dyson PA (2010)reviewMEDLINE-indexed journal, not yet read by usDiabetes, obesity & metabolism59 citations

The therapeutics of lifestyle management on obesity.

The global incidence and prevalence of obesity continue to increase, with the fastest rate of increase in the developing world. Obesity is associated with many chronic diseases including type 2 diabetes, cardiovascular disease and some cancers. Weight loss can reduce the risk of developing these diseases and can be achieved by means of surgery, pharmacotherapy and lifestyle interventions. Lifestyle interventions for prevention and treatment of obesity include diet, exercise and psychological interventions. All lifestyle interventions have a modest but significant effect on weight loss, but there is little evidence to indicate that any one intervention is more effective. There is evidence of an additive effect for adjunct therapy, and the combination of diet, exercise and behavioural interventions appears to be most effective for both the prevention and treatment of obesity.

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Su KP (2009)reviewMEDLINE-indexed journal, not yet read by usNeuro-Signals120 citations

Biological mechanism of antidepressant effect of omega-3 fatty acids: how does fish oil act as a 'mind-body interface'?

The unsatisfactory results of monoamine-based antidepressant therapy and the high occurrence of somatic symptoms and physical illness in patients with depression imply that the serotonin hypothesis is insufficient to approach the aetiology of depression. Depressive disorders with somatic presentation are the most common form of depression. Somatization, the bodily symptoms without organic explanation, is similar to cytokine-induced sickness behaviour. Based on recent evidence, omega-3 polyunsaturated fatty acids (n-3 PUFAs, or n-3 fatty acids) are enlightening a promising path to discover the unsolved of depression, sickness behaviour and to link the connection of mind and body. The PUFAs are classified into n-3 (or omega-3) and n-6 (or omega-6) groups. Eicosapentaenoic acid and docosahexaenoic acid, the major bioactive components of n-3 PUFAs, are not efficiently synthesized in humans a

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Berge JM (2009)reviewMEDLINE-indexed journal, not yet read by usInternational journal of adolescent medicine and health137 citations

A review of familial correlates of child and adolescent obesity: what has the 21st century taught us so far?

Unlabelled: With the rising prevalence rates of child and adolescent obesity over the last several decades, it is important to examine the extant research to inform future research. Objective: The aim of this paper was to review and critique research investigating familial correlates of child and adolescent obesity in the last decade. Methods: A literature review was conducted between March 2008 and December 2008. Studies published after 2000 that assessed familial associations with child and adolescent obesity in the parental, family functioning, and sibling domains were included in the review. A total of 80 studies met the inclusion criteria. Results: The majority of studies focused on the parental domain. Substantial evidence indicates an association between authoritative parenting style and child/adolescent lower BMI, healthy dietary intake, and physical activity. Also, research on f

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Middleton LE, Yaffe K (2009)reviewMEDLINE-indexed journal, not yet read by usArchives of neurology228 citations

Promising strategies for the prevention of dementia.

The incidence and prevalence of dementia are expected to increase several-fold in the coming decades. Given that the current pharmaceutical treatment of dementia can only modestly improve symptoms, risk factor modification remains the cornerstone for dementia prevention. Some of the most promising strategies for the prevention of dementia include vascular risk factor control, cognitive activity, physical activity, social engagement, diet, and recognition of depression. In observational studies, vascular risk factors-including diabetes, hypertension, dyslipidemia, and obesity-are fairly consistently associated with increased risk of dementia. In addition, people with depression are at high risk for cognitive impairment. Population studies have reported that intake of antioxidants or polyunsaturated fatty acids may be associated with a reduced incidence of dementia, and it has been reporte

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