Physical activity and exercise

مَا تَذَرُ مِن شَيۡءٍ أَتَتۡ عَلَيۡهِ إِلَّا جَعَلَتۡهُ كَٱلرَّمِيمِ

and it reduced everything it came up against to shreds

قَالَ قَآئِلࣱ مِّنۡهُمۡ لَا تَقۡتُلُواْ يُوسُفَ وَأَلۡقُوهُ فِي غَيَٰبَتِ ٱلۡجُبِّ يَلۡتَقِطۡهُ بَعۡضُ ٱلسَّيَّارَةِ إِن كُنتُمۡ فَٰعِلِينَ

[Another of them] said, ‘Do not kill Joseph, but, if you must, throw him into the hidden depths of a well where some caravan may pick him up.’

ٱذۡهَبُواْ بِقَمِيصِي هَٰذَا فَأَلۡقُوهُ عَلَىٰ وَجۡهِ أَبِي يَأۡتِ بَصِيرࣰ ا وَأۡتُونِي بِأَهۡلِكُمۡ أَجۡمَعِينَ

Take my shirt and lay it over my father’s face: he will recover his sight. Then bring your whole family back to me.’

وَمِنَ ٱلنَّاسِ مَن يَتَّخِذُ مِن دُونِ ٱللَّهِ أَندَادࣰ ا يُحِبُّونَهُمۡ كَحُبِّ ٱللَّهِۖ وَٱلَّذِينَ ءَامَنُوٓاْ أَشَدُّ حُبࣰّ ا لِّلَّهِۗ وَلَوۡ يَرَى ٱلَّذِينَ ظَلَمُوٓاْ إِذۡ يَرَوۡنَ ٱلۡعَذَابَ أَنَّ ٱلۡقُوَّةَ لِلَّهِ جَمِيعࣰ ا وَأَنَّ ٱللَّهَ شَدِيدُ ٱلۡعَذَابِ

Even so, there are some who choose to worship others besides God as rivals to Him, loving them with the love due to God, but the believers have greater love for God. If only the idolaters could see- as they will see when they face the torment- that all power belongs to God, and that God punishes severely

۞إِنَّ قَٰرُونَ كَانَ مِن قَوۡمِ مُوسَىٰ فَبَغَىٰ عَلَيۡهِمۡۖ وَءَاتَيۡنَٰهُ مِنَ ٱلۡكُنُوزِ مَآ إِنَّ مَفَاتِحَهُۥ لَتَنُوٓأُ بِٱلۡعُصۡبَةِ أُوْلِي ٱلۡقُوَّةِ إِذۡ قَالَ لَهُۥ قَوۡمُهُۥ لَا تَفۡرَحۡۖ إِنَّ ٱللَّهَ لَا يُحِبُّ ٱلۡفَرِحِينَ

Qarun was one of Moses’ people, but he oppressed them. We had given him such treasures that even their keys would have weighed down a whole company of strong men. His people said to him, ‘Do not gloat, for God does not like people who gloat

قَالُواْ ٱبۡنُواْ لَهُۥ بُنۡيَٰنࣰ ا فَأَلۡقُوهُ فِي ٱلۡجَحِيمِ

They said, ‘Build a pyre and throw him into the blazing fire.’

Go with this shirt of mine and cast it upon the face of my father so that he may come to seeing. Joseph said, " Take my shirt to Jacob, for his pain has not ceased from the time he saw the shirt stained with the wolf's blood. The balm will also be my shirt. " When they took the shirt from Egypt, the morning breeze was commanded to take the shirt's scent to Jacob's nostrils so that, before Joseph's messenger could give the good news, he would receive it from the Real's mes- senger and recognize the Real's perfect gentleness and favor toward him. According to the tasting of the recognizers, this is the divine breeze that wanders furtively around the world to the doors of the breasts of the faithful and the tawḤīd-voicers to see where there may be a limpid breast and an empty secret core in which to dwell. Her love came to me before I knew love- it came across a carefree heart and took poss

Among the people are some who take peers apart from God, loving them as if loving God. And those who have faith are more intense in love for God. If this were the only verse in the whole Qur'an about the faithful and God's friends, their eminence and honor would be complete, for the Lord of the Worlds is saying, “They love Me intensely and more completely than the unbelievers love their objects of worship.” Do you not see that every once in a while the unbelievers set up another idol and take up another object of worship. Like poor people, they are content with something carved of wood. Then, when they can, they take down the wooden one and make another from silver or gold. If their love for their object of wor- ship is real, why do they turn away from it toward another? They say that a man met a woman recognizer, and her beauty exercised its influence over his heart. He said, “'My all i

It did not leave anything any soul or property that it came upon without making it like decayed bones like something that is withered and in scattered pieces.

And in Musa, when We sent him to Fir'awn with a manifest authority (38)But (he) turned away along with his hosts, and said: "A sorcerer or a madman. (39)So We took him and his armies, and dumped them into the sea (Yamm), for he was blameworthy (40)And in 'Ad when We sent against them the barren wind (41)It spared nothing that it reached, but blew it into broken spreads of rotten ruins (42)And in Thamud, when they were told: "Enjoy yourselves for a while! (43)But they insolently defied the command of their Lord, so the Sa'iqah overtook them while they were looking (44)Then they were unable to rise up, nor could they help themselves (45)(So were) the people of Nuh before them. Verily, they were a people who were rebellious (46) Lessons from the Destruction of Fir'awn, 'Ad, Thamud, and the People of Nuh Allah the Exalted said, وَفِي مُوسَىٰ إِذْ أَرْسَلْنَاهُ إِلَىٰ فِرْعَوْنَ بِسُلْطَان

One of them namely Judah said ‘Do not kill Joseph but cast him throw him into the bottom of a well ghayābat al-jubb is the darkest recess of a well; a variant reading has the plural ghayābāt so that some caravan might pick him up if you are to do anything’ of what you desire in the way of separating Joseph from us so content yourselves with this solution.

Yet there be people who take to themselves compeers idols besides God that is other than God loving them by magnifying them and being subservient to them as God is loved that is as their love of Him; but those who believe love God more ardently than those who love their compeers because the former never reject God whereas the latter when faced with hardship soon abandon those compeers for God; If he if you O Muhammad (s) were to see those who did evil by taking to themselves compeers when idh here denotes idhā they see read either as active yarawna ‘they see’ or passive yurawna ‘they are made to see’ the chastisement you would see a grave sight that this is because the might the power and the vanquishing altogether a circumstantial qualifier belongs to God and that God is terrible in chastisement according to one reading the person listening to the verse governs the verb yarā ‘he sees’ a

حَدَّثَنَا أَحْمَدُ بْنُ مَنِيعٍ، حَدَّثَنَا يَزِيدُ بْنُ هَارُونَ، حَدَّثَنَا الْحَجَّاجُ، عَنْ مَكْحُولٍ، عَنْ أَبِي ثَعْلَبَةَ، وَالْحَجَّاجُ، عَنِ الْوَلِيدِ بْنِ أَبِي مَالِكٍ، عَنْ عَائِذِ اللَّهِ بْنِ عَبْدِ اللَّهِ، أَنَّهُ سَمِعَ أَبَا ثَعْلَبَةَ الْخُشَنِيَّ، قَالَ قُلْتُ يَا رَسُولَ اللَّهِ إِنَّا أَهْلُ صَيْدٍ ‏.‏ قَالَ ‏"‏ إِذَا أَرْسَلْتَ كَلْبَكَ وَذَكَرْتَ اسْمَ اللَّهِ عَلَيْهِ فَأَمْسَكَ عَلَيْكَ فَكُلْ ‏"‏ ‏.‏ قُلْتُ وَإِنْ قَتَلَ قَالَ ‏"‏ وَإِنْ قَتَلَ ‏"‏ ‏.‏ قُلْتُ إِنَّا أَهْلُ رَمْىٍ ‏.‏ قَالَ ‏"‏ مَا رَدَّتْ عَلَيْكَ قَوْسُكَ فَكُلْ ‏"‏ ‏.‏ قَالَ قُلْتُ إِنَّا أَهْلُ سَفَرٍ نَمُرُّ بِالْيَهُودِ وَالنَّصَارَى وَالْمَجُوسِ فَلاَ نَجِدُ غَيْرَ آنِيَتِهِمْ ‏.‏ قَالَ ‏"‏ فَإِنْ لَمْ تَجِدُوا غَيْرَهَا فَاغْسِلُوهَا بِالْمَاءِ ثُمَّ كُلُوا فِيهَا وَاشْرَبُوا ‏"‏ ‏.‏ قَالَ وَفِي الْبَابِ عَنْ عَدِيِّ بْنِ حَاتِمٍ ‏.‏ قَالَ أَبُو عِيسَى هَذَا حَدِيثٌ حَسَنٌ صَحِيحٌ ‏.‏ وَعَائِذُ اللَّهِ بْنُ عَبْدِ اللَّهِ هُوَ أَبُو إِدْرِيسَ الْخَوْلاَنِيُّ وَاسْمُ أَبِي ثَعْلَبَةَ الْخُشَنِيِّ جُرْثُومٌ وَيُقَالُ جُرْثُمُ بْنُ نَاشِرٍ وَيُقَالُ ابْنُ قَيْسٍ ‏.‏

Narrated Abu Tha'labah Al-Khushani:"I said: 'O Messenger of Allah! We are a people who hunt.' He said: 'If you send your dog and you mentioned the Name of Allah upon it, and he catches something for you, then eat it.' I said: 'Even if he kills it?' He said: 'Even if he kills it.' I said: 'We are a people who shoot (at game).' He said: 'What you catch with your bow, then eat it.'" He said: "Then I said:'Indeed we are a people who travel. We come across Jews, Christians, and Zoroastrians, and we do not find vessels other than theirs.' He said: 'If you do not find other than them, then wash them with water, then eat and drink from it

أَخْبَرَنَا أَحْمَدُ بْنُ عَبْدِ الْوَاحِدِ، قَالَ حَدَّثَنَا مَرْوَانُ، - وَهُوَ ابْنُ مُحَمَّدٍ - قَالَ حَدَّثَنَا خَالِدُ بْنُ يَزِيدَ بْنِ صَالِحِ بْنِ صَبِيحٍ الْمُرِّيُّ، قَالَ حَدَّثَنَا إِبْرَاهِيمُ بْنُ أَبِي عَبْلَةَ، عَنِ الْوَلِيدِ بْنِ عَبْدِ الرَّحْمَنِ الْجُرَشِيِّ، عَنْ جُبَيْرِ بْنِ نُفَيْرٍ، عَنْ سَلَمَةَ بْنِ نُفَيْلٍ الْكِنْدِيِّ، قَالَ كُنْتُ جَالِسًا عِنْدَ رَسُولِ اللَّهِ صلى الله عليه وسلم فَقَالَ رَجُلٌ يَا رَسُولَ اللَّهِ أَذَالَ النَّاسُ الْخَيْلَ وَوَضَعُوا السِّلاَحَ وَقَالُوا لاَ جِهَادَ قَدْ وَضَعَتِ الْحَرْبُ أَوْزَارَهَا فَأَقْبَلَ رَسُولُ اللَّهِ صلى الله عليه وسلم بِوَجْهِهِ وَقَالَ ‏ "‏ كَذَبُوا الآنَ الآنَ جَاءَ الْقِتَالُ وَلاَ يَزَالُ مِنْ أُمَّتِي أُمَّةٌ يُقَاتِلُونَ عَلَى الْحَقِّ وَيُزِيغُ اللَّهُ لَهُمْ قُلُوبَ أَقْوَامٍ وَيَرْزُقُهُمْ مِنْهُمْ حَتَّى تَقُومَ السَّاعَةُ وَحَتَّى يَأْتِيَ وَعْدُ اللَّهِ وَالْخَيْلُ مَعْقُودٌ فِي نَوَاصِيهَا الْخَيْرُ إِلَى يَوْمِ الْقِيَامَةِ وَهُوَ يُوحَى إِلَىَّ أَنِّي مَقْبُوضٌ غَيْرَ مُلَبَّثٍ وَأَنْتُمْ تَتَّبِعُونِي أَفْنَادًا يَضْرِبُ بَعْضُكُمْ رِقَابَ بَعْضٍ وَعُقْرُ دَارِ الْمُؤْمِنِينَ الشَّامُ ‏"‏ ‏.‏

It was narrated that Salamah bin Nufail Al-Kindi said:"I was sitting with the Messenger of Allah when a man said: 'O Messenger of Allah! The people have lost interest in horses and put down their weapons, and they say there is no Jihad, and that war has ended.' The Messenger of Allah turned to face him and said: 'They are lying, now the fighting is to come. There will always be a group among my Ummah who will fight for the truth, for whom Allah will cause some people to deviate, and grant them provision from them, until the Hour begins and until the promise of Allah comes. Goodness is tied to the forelocks of horses until the Day of Resurrection. It has been revealed to me that I am going to die and will not stay long, and you will follow me group after group, striking one another's necks. And the place of safety for the believers is Ash-Sham

أَخْبَرَنَا عَمْرُو بْنُ يَحْيَى بْنِ الْحَارِثِ، قَالَ حَدَّثَنَا مَحْبُوبُ بْنُ مُوسَى، قَالَ حَدَّثَنَا أَبُو إِسْحَاقَ، - يَعْنِي الْفَزَارِيَّ - عَنْ سُهَيْلِ بْنِ أَبِي صَالِحٍ، عَنْ أَبِيهِ، عَنْ أَبِي هُرَيْرَةَ، قَالَ قَالَ رَسُولُ اللَّهِ صلى الله عليه وسلم ‏ "‏ الْخَيْلُ مَعْقُودٌ فِي نَوَاصِيهَا الْخَيْرُ إِلَى يَوْمِ الْقِيَامَةِ الْخَيْلُ ثَلاَثَةٌ فَهِيَ لِرَجُلٍ أَجْرٌ وَهِيَ لِرَجُلٍ سَتْرٌ وَهِيَ عَلَى رَجُلٍ وِزْرٌ فَأَمَّا الَّذِي هِيَ لَهُ أَجْرٌ فَالَّذِي يَحْتَبِسُهَا فِي سَبِيلِ اللَّهِ فَيَتَّخِذُهَا لَهُ وَلاَ تُغَيِّبُ فِي بُطُونِهَا شَيْئًا إِلاَّ كُتِبَ لَهُ بِكُلِّ شَىْءٍ غَيَّبَتْ فِي بُطُونِهَا أَجْرٌ وَلَوْ عَرَضَتْ لَهُ مَرْجٌ ‏"‏ ‏.‏ وَسَاقَ الْحَدِيثَ ‏.‏

It was narrated that Abu Hurairah said:"The Messenger of Allah said: 'There is goodness tied to the forelocks of horses until the Day of Resurrection. And horses are of three types: Those that bring reward to man, those that are a means of protection for a man, and those that are a burden (of sin) for a man. As for those that bring reward, they are kept for the cause of Allah and for Jihad. No fodder enters their stomach but for everything that enters their stomachs, reward is written for him, even if he puts them out to pasture.'" And he quoted the Hadith

حَدَّثَنَا نَصْرُ بْنُ عَلِيٍّ الْجَهْضَمِيُّ، حَدَّثَنَا الْمُعْتَمِرُ بْنُ سُلَيْمَانَ، عَنْ أَبِيهِ، عَنْ أَبِي إِسْحَاقَ، عَنِ الْبَرَاءِ بْنِ عَازِبٍ، أَنَّ رَسُولَ اللَّهِ صلى الله عليه وسلم قَالَ ‏"‏ ائْتُونِي بِالْكَتِفِ أَوِ اللَّوْحِ ‏"‏ ‏.‏ فَكَتَبَ ‏:‏ ‏(‏ لاَ يَسْتَوِي الْقَاعِدُونَ مِنَ الْمُؤْمِنِينَ ‏)‏ وَعَمْرُو بْنُ أُمِّ مَكْتُومٍ خَلْفَ ظَهْرِهِ فَقَالَ هَلْ لِي مِنْ رُخْصَةٍ فَنَزَلَتْ ‏:‏ ‏(‏ غَيْرُ أُولِي الضَّرَرِ ‏)‏ ‏.‏ وَفِي الْبَابِ عَنِ ابْنِ عَبَّاسٍ وَجَابِرٍ وَزَيْدِ بْنِ ثَابِتٍ ‏.‏ وَهَذَا حَدِيثٌ حَسَنٌ صَحِيحٌ وَهُوَ حَدِيثٌ غَرِيبٌ مِنْ حَدِيثِ سُلَيْمَانَ التَّيْمِيِّ عَنْ أَبِي إِسْحَاقَ ‏.‏ وَقَدْ رَوَى شُعْبَةُ وَالثَّوْرِيُّ عَنْ أَبِي إِسْحَاقَ هَذَا الْحَدِيثَ ‏

Narrated Al-Bara' bin 'Azib: That the Messenger of Allah (ﷺ) said: "Bring me a shoulder blade or tablet." Then he wrote: Not equal are those of believers who sit. 'Amr bin Umm Maktum who was behind him said: "Is there an exemption for me?" So the following was revealed: Except those who are disabled. There are narrations on this topic from Ibn 'Abbas, Jabir and Zaid bin Thabit. This Hadith is Hasan Sahih and it is a Hadith that is Gharib from the narration of Sulaiman At-Taimi from Abu Ishaq. And Shu'bah and Ath-Thawri reported this Hadith from Abu Ishaq

حَدَّثَنَا مُحَمَّدُ بْنُ بَشَّارٍ، حَدَّثَنَا يَحْيَى بْنُ سَعِيدٍ، عَنْ سُفْيَانَ، وَشُعْبَةَ، عَنْ حَبِيبِ بْنِ أَبِي ثَابِتٍ، عَنْ أَبِي الْعَبَّاسِ، عَنْ عَبْدِ اللَّهِ بْنِ عَمْرٍو، قَالَ جَاءَ رَجُلٌ إِلَى النَّبِيِّ صلى الله عليه وسلم يَسْتَأْذِنُهُ فِي الْجِهَادِ فَقَالَ ‏"‏ أَلَكَ وَالِدَانِ ‏"‏ ‏.‏ قَالَ نَعَمْ ‏.‏ قَالَ ‏"‏ فَفِيهِمَا فَجَاهِدْ ‏"‏ ‏.‏ قَالَ أَبُو عِيسَى وَفِي الْبَابِ عَنِ ابْنِ عَبَّاسٍ ‏.‏ وَهَذَا حَدِيثٌ حَسَنٌ صَحِيحٌ ‏.‏ وَأَبُو الْعَبَّاسِ هُوَ الشَّاعِرُ الأَعْمَى الْمَكِّيُّ وَاسْمُهُ السَّائِبُ بْنُ فَرُّوخَ ‏.‏

Narrated 'Abdullah bin 'Umar: A man came to Prophet (ﷺ) seeking permission to go for Jihad. So he said: 'Do you have parents (living)? ' He said: 'Yes.' He said: 'Then it is for them that you should perform Jihad.'" [Abu 'Eisa said:] There is something on this topic from Ibn 'Abbas. This Hadith is Hasan Sahih. (One of the narrators) Abul-Abbas is the blind (Al-A'ma) poet (Ash-Sha'ir), from Makkah, and his name is As-Sa'ab bin Farrukh

وصفات الفعل والقدرة والتفرد بالضر والنفع والعطاء والمنع ونفوذ المشيئة وكمال القوة وتدبير أمر الخليقة أخص باسم الرب

فمنشأ الغلط التسوية بين المشيئة والمحبة واعتقادهم وجوب الرضا بالقضاء ونحن نبين ما في الفصلين إن شاء الله تعالى فإن القوة لله جميعا

المثال الأول أن نقول مثل نفس الإنسان في بدنه أعني بالنفس اللطيفة المذكورة كمثل ملك في مدينته ومملكته فإن البدن مملكة النفس وعالمها ومستقرها ومدينتها وجوارحها وقواها بمنزلة الصناع والعملة والقوة العقلية المفكرة له كالمشير الناصح والوزير العاقل

1332 وعن أبي حماد ويقال أبو سعاد ويقال أبو أسد ويقال أبو عامر ويقال أبو عمرو ويقال أبو الأسود ويقال أبو عبس عقبة بن عامر الجهني رضي الله عنه قال سمعت رسول الله صلى الله عليه وسلم وهو على المنبر يقول وأعدوا لهم ما استطعتم من قوة ألا إن القوة الرمي ألا إن القوة الرمي ألا إن القوة الرمي رواه مسلم

السير في طلبها سير في أرض مسبعة والسباحة فيها سباحة في غدير التمساح المفروح به منها هو عين المحزون عليه آلامها متولدة من لذاتها واحزانها من أفراحها

فهذا وأمثاله من الأسباب مع الانهماك في الشهوات هو الذي سد على الخلق سبيل الاستضاءة بأنوار المعرفة والسباحة في بحارها الواسعة فالناس في طلبهم معرفة الله كالمدهوش الذى يضرب به المثل إذا كان راكبا لحماره وهو يطلب حماره والجليات إذا صارت مطلوبة صارت معتاصة

Lack of exercise is a major cause of chronic diseases.: Chronic diseases are major killers in the modern era. Physical inactivity is a primary cause of most chronic diseases. The initial third of the article considers: activity and prevention definitions; historical evidence showing physical inactivity is detrimental to health and normal organ functional capacities; cause versus treatment; physical activity and inactivity mechanisms differ; gene-environment interaction (including aerobic training adaptations, personalized medicine, and co-twin physic

High-Intensity Interval Training and Isocaloric Moderate-Intensity Continuous Training Result in Similar Improvements in Body Composition and Fitness in Obese Individuals.: This study aimed to determine the effects of 12 weeks of isocaloric programs of high-intensity intermittent training (HIIT) or moderate-intensity continuous training (MICT) or a short-duration HIIT (1/2HIIT) inducing only half the energy deficit on a cycle ergometer, on body weight and composition, cardiovascular fitness, resting metabolism rate (RMR), respiratory exchange ratio (RER), nonexercise physical activity (PA) levels and fasting and postprandial insulin response in sedentary obese indi

Web-based intervention to promote physical activity by sedentary older adults: randomized controlled trial.: Background: Physical activity (PA) for older adults has well-documented physical and cognitive benefits, but most seniors do not meet recommended guidelines for PA, and interventions are lacking. Objectives: This study evaluated the efficacy of a 12-week Internet intervention to help sedentary older adults over 55 years of age adopt and maintain an exercise regimen. Methods: A total of 368 sedentary men and women (M=60.3; SD 4.9) were recruited, screened, and assessed online. They were randomize

Effect of exercise referral schemes in primary care on physical activity and improving health outcomes: systematic review and meta-analysis.: Objective: To assess the impact of exercise referral schemes on physical activity and health outcomes. Design Systematic review and meta-analysis. Data sources: Medline, Embase, PsycINFO, Cochrane Library, ISI Web of Science, SPORTDiscus, and ongoing trial registries up to October 2009. We also checked study references. Study selection Design: randomised controlled trials or non-randomised controlled (cluster or individual) studies published in peer review journals. Population: sedentary individ

Physical activity patterns among South-Asian adults: a systematic review.: Physical activity (PA) has many beneficial physical and mental health effects. Physical inactivity is considered the fourth leading risk factor for global mortality. At present there are no systematic reviews on PA patterns among South Asian adults residing in the region. The present study aims to systematically evaluate studies on PA patterns in South Asian countries. A five-staged comprehensive search of the literature was conducted in Medline, Web of Science and SciVerse Scopus using keywords

Reducing the decline in physical activity during pregnancy: a systematic review of behaviour change interventions.: Purpose: Physical activity (PA) typically declines throughout pregnancy. Low levels of PA are associated with excessive weight gain and subsequently increase risk of pre-eclampsia, gestational diabetes mellitus, hypertension disorders, delivery by caesarean section and stillbirth. Systematic reviews on PA during pregnancy have not explored the efficacy of behaviour change techniques or related theory in altering PA behaviour. This systematic review evaluated the content of PA interventions to re

Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis.

The loss of muscle mass and strength with aging results in significant functional impairment. Creatine supplementation has been used in combination with resistance training as a strategy for increasing lean tissue mass and muscle strength in older adults, but results across studies are equivocal. We conducted a systematic review and meta-analysis of randomized controlled trials of creatine supplementation during resistance training in older adults with lean tissue mass, chest press strength, and leg press strength as outcomes by searching PubMed and SPORTDiscus databases. Twenty-two studies were included in our meta-analysis with 721 participants (both men and women; with a mean age of 57-70 years across studies) randomized to creatine supplementation or placebo during resistance training 2-3 days/week for 7-52 weeks. Creatine supplementation resulted in greater increases in lean tissue …

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Endothelial nitric oxide: protector of a healthy mind.

Endothelial nitric oxide (NO) is generated by constitutively active endothelial nitric oxide synthase (eNOS), an essential enzyme responsible for cardiovascular homeostasis. Historically, endothelial NO was first recognized as a major vasodilator involved in control of vasomotor function and local blood flow. In this review, our attention is focused on the emerging role of endothelial NO in linking cerebrovascular function with cognition. We will discuss the recognized ability of endothelial NO to modulate processing of amyloid precursor protein (APP), influence functional status of microglia, and affect cognitive function. Existing evidence suggests that the loss of NO in cultured human cerebrovascular endothelium causes increased expression of APP and β-site APP-cleaving enzyme 1 (BACE1) thereby resulting in increased secretion of amyloid β peptides (Aβ1-40 and Aβ1-42). Furthermore, in…

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Diet and exercise in management of obesity and overweight.

According to World Health Organization, in 2010 there were over 1 billion overweight adults worldwide with 400 million adults who were obese. Obesity is a major risk factor for diabetes, cardiovascular disease, musculoskeletal disorders, obstructive sleep apnea, and cancers (prostate, colorectal, endometrial, and breast). Obese people may present to the gastroenterologists with gastroesophageal reflux, non-alcoholic fatty liver, and gallstones. It is important, therefore, to recognize and treat obesity. The main cause of obesity is an imbalance between calories consumed and calories expended, although in a small number of cases, genetics and diseases such as hypothyroidism, Cushing's disease, depression, and use of medications such as antidepressants and anticonvulsants are responsible for fat accumulation in the body. The main treatment for obesity is dieting, augmented by physical exer…

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Ghana's 2025 physical activity report card: children, adolescents and CAWD.

Background: Regular physical activity in childhood and adolescence supports cardiometabolic health, mental wellbeing, and learning, yet many countries lack routine surveillance and actionable, benchmark-linked accountability tools. The Active Healthy Kids Global Alliance (AHKGA) "Report Card" approach synthesizes the best available national evidence to grade physical activity behaviours and their determinants, enabling cross-country comparisons and policy dialogue. Ghana last published a Report Card in 2018; since then, new evidence and policy developments warrant an updated appraisal, including attention to children and adolescents with disabilities and/or chronic conditions (CAWD). Methods: We compiled and synthesized Ghana-specific evidence used for the 2025 Ghana Report Card within the AHKGA Global Matrix 5.0 framework. Ten common indicators were graded for the regular population (ag…

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Gender and residential differences in sleep quality among Chinese adolescents aged 13-18 years.

Background: Good sleep is essential for healthy adolescent development, yet declining sleep quality among Chinese adolescents has become a nationwide public health concern. Residential setting and sex are key determinants of sleep quality; however, systematic evaluations of sleep quality across regions and between sexes among Chinese adolescents remain limited. Methods: Data were collected on Pittsburgh Sleep Quality Index (PSQI), body mass index (BMI), Physical Fitness Index (PFI), sedentary time, screen time, and mental health from 5,713 adolescents (mean age, 15.11 ± 1.70 years). Logistic regression models were applied to examine the effects of these factors on adolescent sleep quality, including interactions with residence and gender. Results: Overall, 33.71% of Chinese adolescents exhibited poor sleep quality. The prevalence of poor sleep quality was 35.78% among rural adolescents, …

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Neighbourhood-level age-friendliness in urban environments: associations with functional independence and physical activity in older adults after a fall.

Background: Population ageing and urbanisation are reshaping living environments and raising new challenges for promoting health and independence in later life. Age-friendly city initiatives aim to support active ageing, yet the relationship between environmental conditions, housing factors, and functional outcomes remains insufficiently understood. Methods: This cross-sectional study analysed data from participants of the SeFallED study in Oldenburg, Germany, which enrolled community-dwelling older adults (≥60 years) presenting to the emergency department due to a fall. Physical activity was assessed using accelerometry and self-report, life-space mobility using the Life-Space Assessment, and independence using instrumental activities of daily living (iADL). Neighbourhood-level age-friendliness was quantified using the Age-Friendly Cities and Communities Questionnaire (AFCCQ). Multiple …

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The Physical Activity, Imaging, and Ambulatory Testing (PHIAT) Project: Protocol for a High-Frequency Ambulatory Assessment Study.

Background: Multiple independent lines of research on self-regulation point to executive cognitive ability (executive function/cognitive control) as a factor that underlies the capacity to successfully regulate one's thoughts, emotions, and behavior. Critically, while leading theories point to the role of executive control in modifying "in-the-moment" regulatory processes (eg, enacting physical activity, resisting a poor dietary choice, reflecting on a stressful experience), few studies have tested the executive hypothesis at this timescale. Moreover, given the normative changes in executive control across the adult lifespan, it is essential to understand how cognitive aging might impact these processes. Objective: The Physical Activity, Imaging, and Ambulatory Testing (PHIAT) project was designed to test how variation in executive control at multiple timescales (from moment-to-moment wi…

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Lifestyle integrated functional exercise for people with interstitial lung disease (iLiFE): A mixed-methods feasibility study.

Background: People with interstitial lung disease (ILD) present low levels of physical activity (PA) and spend most of their time at home, especially in advanced stages of the disease. The Lifestyle Integrated Functional Exercise for people with ILD (iLiFE) embedding PA in patients' daily routines was developed and implemented. Objectives: This study aimed to explore the feasibility of iLiFE. Methods: A pre/post mixed-methods feasibility study was conducted. Feasibility of iLiFE was determined by participant recruitment/retention, adherence, feasibility of outcome measures and adverse events. Measures of PA, sedentary behaviour, balance, muscle strength, functional performance/capacity, exercise capacity, impact of the disease, symptoms (i.e., dyspnoea, anxiety, depression, fatigue and cough) and health-related quality of life were collected at baseline and post-intervention (12-weeks). …

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The impact of COVID-19 lockdowns on physical activity amongst older adults: evidence from longitudinal data in the UK.

Background: A sedentary lifestyle increases the risk of adverse health outcomes and frailty,particularly for older adults. To reduce transmission during the COVID-19 pandemic, people were instructed to stay at home, group sports were suspended, and gyms were closed, thereby limiting opportunities for physical activity. Whilst evidence suggests that physical activity levels reduced during the pandemic, it is unclear whether the proportion of older adults realising the recommended minimum level of physical activity changed throughout the various stages of lockdown. Methods: We used a large sample of 3,660 older adults (aged ≥ 65) who took part in the UK Household Longitudinal Study's annual and COVID-19 studies. We examined changes in the proportion of older adults who were realising the UK Chief Medical Officers' physical activity recommendations for health maintenance at several time poi…

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Parenting Stress, Child Weight-Related Behaviors, and Child Weight Status.

Background: There has been limited examination of the association between parenting stress and child weight-related behaviors. We aimed to determine whether parenting stress is associated with child weight-related behaviors, including physical activity, screen time, diet, sedentary time, and eating in the absence of hunger (EAH). Secondarily, we assessed association between parenting stress and child weight status. Methods: Mother-child dyads (N = 291) enrolled in the Newborn Epigenetic STudy (NEST), a longitudinal cohort study, completed surveys to describe parenting stress, and child diet. Children participated in the EAH task and wore accelerometers to assess sedentary time and physical activity. Child weight status was assessed using measured height and weight. Outcomes and exposures were examined using generalized linear models and restricted cubic splines as appropriate based on li…

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Impact of replacing sedentary behaviour with other movement behaviours on depression and anxiety symptoms: a prospective cohort study in the UK Biobank.

Background: Sedentary behaviour is potentially a modifiable risk factor for depression and anxiety disorders, but findings have been inconsistent. To assess the associations of sedentary behaviour with depression and anxiety symptoms and estimate the impact of replacing daily time spent in sedentary behaviours with sleep, light, or moderate to vigorous physical activity, using compositional data analysis methods. Methods: We conducted a prospective cohort study in 60,235 UK Biobank participants (mean age: 56; 56% female). Exposure was baseline daily movement behaviours (accelerometer-assessed sedentary behaviour and physical activity, and self-reported total sleep). Outcomes were depression and anxiety symptoms (Patient Health Questionnaire-9 and Generalised Anxiety Disorders-7) at follow-up. Results: Replacing 60 min of sedentary behaviour with light activity, moderate-to-vigorous activ…

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Sedentary Lifestyle: Overview of Updated Evidence of Potential Health Risks.

One-third of the global population aged 15 years and older engages in insufficient physical activities, which affects health. However, the health risks posed by sedentary behaviors are not well known. The mean daily duration of sedentary behavior is 8.3 hours among the Korean population and 7.7 hours among the American adult population. Sedentary lifestyles are spreading worldwide because of a lack of available spaces for exercise, increased occupational sedentary behaviors such as office work, and the increased penetration of television and video devices. Consequently, the associated health problems are on the rise. A sedentary lifestyle affects the human body through various mechanisms. Sedentary behaviors reduce lipoprotein lipase activity, muscle glucose, protein transporter activities, impair lipid metabolism, and diminish carbohydrate metabolism. Furthermore, it decreases cardiac o…

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Quarantine during COVID-19 outbreak: Changes in diet and physical activity increase the risk of cardiovascular disease.

Aims: CoV-19/SARS-CoV-2 is a highly pathogenic virus that is causing a global pandemic with a high number of deaths and infected people. To contain the diffusion of infection, several governments have enforced restrictions on outdoor activities or even collective quarantine on the population. The present commentary briefly analyzes the effects of quarantine on lifestyle, including nutrition and physical activity and the impact of new technologies in dealing with this situation. Data synthesis: Quarantine is associated with stress and depression leading to unhealthy diet and reduced physical activity. A diet poor in fruit and vegetables is frequent during isolation, with a consequent low intake of antioxidants and vitamins. However, vitamins have recently been identified as a principal weapon in the fight against the Cov-19 virus. Some reports suggest that Vitamin D could exert a protecti…

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Nurses and health-promoting self-care: Do we practice what we preach?

Aims: To examine the health-promoting behaviours performed by registered nurses (RNs), as well as workplace factors that influence participation in those behaviours. Background: Nurses have high levels of overweight/obesity and may not be engaging in health-promoting self-care. Methods: A cross-sectional Web-based survey collected information from 335 RNs regarding their physical activity, sedentariness and fruit/vegetable consumption. Results: More than half were overweight (34.1%) or obese (23.4%), and 80.1% were "sedentary" (≥3 hr sitting/day), particularly those working outside of direct patient care in management, research and education. Only 47.2% consumed 5+ servings of fruits/vegetables daily. Nurses who enjoyed their jobs (higher levels of compassion satisfaction) reported higher levels of physical activity (p = 0.03) and fruit/vegetable consumption (p = 0.02). Conclusion: RNs w…

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Health outcomes and adherence to a healthy lifestyle after a multimodal intervention in people with multiple sclerosis: Three year follow-up.

Background: Modifiable risk factors such as smoking and sedentary lifestyle adversely affect multiple sclerosis (MS) progression. Few multimodal behavioural interventions have been conducted for people with MS, and follow-up beyond 1 year is rare for lifestyle interventions. This study assessed adoption and adherence to healthy lifestyle behaviours and health outcomes 3 years after a lifestyle modification intervention, using generalized estimating equation models to account for within-participant correlation over time. Methods: 95 people with MS completed baseline surveys before participating in 5-day MS lifestyle risk-factor modification workshops. 76 and 78 participants completed the 1-year and 3-year follow-up surveys respectively. Mean age at 3-year follow-up was 47 years, 72% were female, most (62.8%) had MS for 5 years or less, and 73% had relapsing remitting MS (RRMS). Results: C…

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The outcomes of health-promoting communities: being active eating well initiative-a community-based obesity prevention intervention in Victoria, Australia.

Objective: The aim of this study is to evaluate the impact of the Health-Promoting Communities: Being Active Eating Well (HPC:BAEW, 2007-2010) initiative, which comprised community-based multi-component interventions adapted to community context in five separate communities. The intervention aimed to promote healthy eating, physical activity and stronger, healthier communities. Methods: A mixed method and multilevel quasi-experimental evaluation of the HPC:BAEW initiative captured process, impact and outcome data. The evaluation involved both cross-sectional (children and adolescents) and longitudinal designs (adults) with data collected pre- and post-intervention in intervention (n=2408 children and adolescents from 18 schools, n=501 adults from 22 workplaces) and comparison groups (n=3163 children and adolescents from 33 schools, n=318 adults from seven workplaces). Anthropometry, obes…

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A behaviour change intervention to reduce sedentary time in people with chronic obstructive pulmonary disease: protocol for a randomised controlled trial.

Introduction: Replacing sedentary behaviour with light intensity physical activity (ie, activities classified as less than three metabolic equivalents, such as slow-paced walking) may be a more realistic strategy for reducing cardiometabolic risk in people with chronic obstructive pulmonary disease than only aiming to increase levels of moderate-vigorous intensity physical activity. Behaviour change interventions to reduce sedentary behaviour in people with chronic obstructive pulmonary disease have not yet been developed or tested. Research questions: Is a 6-week behaviour change intervention effective and feasible in reducing sedentary time in people with chronic obstructive pulmonary disease? Design: This study will be a multi-centre, randomised, controlled trial with concealed allocation, assessor blinding, and intention-to-treat analysis, comparing a 6-week behaviour change interven…

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Lack of sleep as a contributor to obesity in adolescents: impacts on eating and activity behaviors.

Background: Sleep is an important contributor to physical and mental health; however, chronic sleep deprivation has become common in adolescents, especially on weekdays. Adolescents aged 14-17 years are recommended to sleep between 8 and 10 h per night to maximize overall health and well-being. Although sleep needs may vary between individuals, sleep duration recommendations are important for surveillance and help inform policies, interventions, and the population of healthy sleep behaviors. Long sleepers are very rare among teenagers and sleeping too much is not a problem per se; only insufficient sleep is associated with adverse health outcomes in the pediatric population. Causes of insufficient sleep are numerous and chronic sleep deprivation poses a serious threat to the academic success, health and safety of adolescents. This article focuses on the link between insufficient sleep an…

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Meeting physical activity guidelines is associated with lower allostatic load and inflammation in Mexican Americans.

Examine the relationship between physical activity (PA) and allostatic load in Mexican-Americans as well as variations by gender. Self-reported PA as well as cardiovascular, metabolic and inflammatory markers were assessed in 330 Mexican-American adults in the Cameron County Hispanic Cohort (Brownsville, TX, USA). Dependent variables included total allostatic load, blood pressure, metabolic, and inflammatory scores. PA participation was categorized as sedentary, low, moderate, high, and by whether activity was sufficient to meet public health guidelines. Logistic regression analyses were conducted using cross-sectional data, and tested interaction effects of gender and PA. High active participants had lower allostatic load and inflammatory risk than sedentary participants. These relationships held for meeting versus not meeting guidelines. Males meeting guidelines were less likely to hav…

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Screen time is associated with depression and anxiety in Canadian youth.

Objective: This study examined the relationships between screen time and symptoms of depression and anxiety in a large community sample of Canadian youth. Method: Participants were 2482 English-speaking grade 7 to 12 students. Cross-sectional data collected between 2006 and 2010 as part of the Research on Eating and Adolescent Lifestyles (REAL) study were used. Mental health status was assessed using the Children's Depression Inventory and the Multidimensional Anxiety Scale for Children-10. Screen time (hours/day of TV, video games, and computer) was assessed using the Leisure-Time Sedentary Activities questionnaire. Results: Linear multiple regressions indicated that after controlling for age, sex, ethnicity, parental education, geographic area, physical activity, and BMI, duration of screen time was associated with severity of depression (β=0.23, p<0.001) and anxiety (β=0.07, p<0.01). …

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Associations of overall sitting time and TV viewing time with fibrinogen and C reactive protein: the AusDiab study.

Background/aim: Sedentary behaviour is associated with increased risk for all-cause and cardiovascular mortality. Plasma fibrinogen and C reactive protein (CRP)-key inflammatory and/or haemostatic markers-may contribute to this association; however, few studies have examined their relationships with sedentary behaviours. We examined associations of overall sitting and TV viewing time with fibrinogen and high-sensitivity CRP (hsCRP). Methods: Plasma fibrinogen and hsCRP were measured in 3086 Australian adults (mean age: 55±12 years) who participated in the 2004-2005 AusDiab (Australian Diabetes, Obesity and Lifestyle) study. Multiple linear regression analyses examined cross-sectional associations of self-reported overall sitting and TV viewing time (h/day) with plasma fibrinogen and hsCRP, adjusting for sociodemographic, behavioural and medical treatments and conditions as potential cova…

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Television viewing time in Hong Kong adult population: associations with body mass index and obesity.

Background: Obesity is increasing dramatically in the Asia-Pacific region particularly China. The population of Hong Kong was exposed to modernization far earlier than the rest of China, reflecting conditions that are likely to be replicated as other Chinese cities undergo rapid change. This study examined the relationship between television viewing and obesity in a Hong Kong sample. Information about the relationship between a key sedentary behavior, TV viewing, and obesity, and its moderation by demographic characteristics may identify sectors of the population at highest risk for excess weight. Methods: Data were from Hong Kong Family and Health Information Trends Survey (2009-2010), a population-based survey on the public's use of media for health information and family communication by telephone interviews with 3,016 Hong Kong adults (age ≥ 18 years). TV viewing time, body mass inde…

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Socio-demographic correlates of prolonged television viewing time in Australian men and women: the AusDiab study.

Background: Sedentary behaviors, particularly television viewing (TV) time, are associated with adverse health outcomes in adults, independent of physical activity levels. These associations are stronger and more consistent for women than for men. Methods: Multivariate regression models examined the sociodemographic correlates of 2 categories of TV time (≥ 2 hours/day and ≥ 4 hours/day); in a large, population-based sample of Australian adults (4950 men, 6001 women; mean age 48.1 years, range 25-91) who participated in the 1999/2000 Australian Diabetes, Obesity, and Lifestyle (AusDiab) study. Results: Some 46% of men and 40% of women watched ≥ 2 hours TV/day; 9% and 6% respectively watched ≥ 4 hours/day. For both men and women, ≥ 2 hours TV/day was associated with less than tertiary education, living outside of state capital cities, and having no paid employment. For women, mid and older…

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Perceived barriers to physical activity among older adults residing in long-term care institutions.

Aims: This study explored barriers that older residents of long-term care (LTC) institutions experience in regular physical activity participation. Background: Despite the benefits of physical activity, a large proportion of older adults still lead a sedentary lifestyle. Especially, for older residents of LTC institutions, ability and resources for practising physical activity are more restricted than community-dwelling older adults. They are very likely to encounter barriers to physical activity. However, little is known about what factors impede them from being physically active. To implement successful interventions, more information is needed to address barriers to regular physical activity. Design: A qualitative exploratory design. Methods: Purposive sampling was performed to recruit 90 older residents from six nursing homes in Taiwan. The interview transcripts were analysed by qual…

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Stemming the global obesity epidemic: what can we learn from data about social and economic trends?

Although the policy debate is only slowly moving away from the focus on individual-level psychological and social factors, the research community has largely recognized that changes in dietary and physical activity patterns are driven by changes in the environment and by the incentives that people face. Many factors have been suggested as causes of the 'obesity epidemic'. Putting a multitude of isolated data points into a coherent picture is a challenging, but necessary, task to assess whether proposed solutions are promising or likely to lead down a blind alley. Conventional wisdom is an unreliable guide and some widely held beliefs are incorrect. Can one distinguish between important and less important behavioural changes and relate them to environmental incentives? People face trade-offs in allocating their scarce resources of time and money to best achieve their goals, including heal…

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