Sexual health and intimacy

أَئِنَّكُمۡ لَتَأۡتُونَ ٱلرِّجَالَ شَهۡوَةࣰ مِّن دُونِ ٱلنِّسَآءِۚ بَلۡ أَنتُمۡ قَوۡمࣱ تَجۡهَلُونَ

How can you lust after men instead of women? What fools you are!’

إِنَّكُمۡ لَتَأۡتُونَ ٱلرِّجَالَ شَهۡوَةࣰ مِّن دُونِ ٱلنِّسَآءِۚ بَلۡ أَنتُمۡ قَوۡمࣱ مُّسۡرِفُونَ

You lust after men rather than women! You transgress all bounds!’

What! Do you read a-innakum pronouncing both hamzas or by not pronouncing the second and inserting an alif between the two in both cases come unto men in lust instead of women? Nay but you are truly a people in ignorance’ of the consequence of your action.

Do you read a-innakum pronouncing both hamzas or by not pronouncing the second one but in both cases inserting an alif between the two; a variant reading has innakum ‘indeed you … ’ come lustfully to men instead of women? Nay you are a wanton folk’ transgressing the bounds going from what is lawful to what is unlawful.

And (remember) Lut! When he said to his people: "Do you commit immoral sins while you see? (54)"Do you practice your lusts on men instead of women? Nay, but you are a people who behave senselessly. (55)There was no other answer given by his people except that they said: "Drive out the family of Lut from your city. Verily, these are men who want to be clean and pure! (56)So, We saved him and his family, except his wife. We destined her to be of those who remained behind (57)And We rained down on them a rain. So, evil was the rain of those who were warned (58) Lut and His People Allah tells us about His servant and Messenger Lut, peace be upon him, and how he warned his people of Allah's punishment for committing an act of immorality which no human ever committed before them – intercourse with males instead of females. This is a major sin, whereby men are satisfied with men and women are

And (remember) Lut, when he said to his people: "Do you commit lewdness such as none preceding you has committed in all of the nations (80)"Verily, you practice your lusts on men instead of women. Nay, but you are a people transgressing beyond bounds. (81) Allah said, We sent, وَ (And) لُوطًا إِذْ قَالَ لِقَوْمِهِ (Lut, when he said to his people..) Lut (Lot) is the son of Haran the son of Azar (Terah), and he was the nephew of Ibrahim, peace be upon them both. Lut had believed in Ibrahim and migrated with him to the Sham area. Allah then sent Lut to the people of Sadum (Sodom) and the surrounding villages, to call them to Allah, enjoin righteousness and forbid them from their evil practices, their sin, and wickedness. It this area, they did things that none of the children of Adam or any other creatures ever did before them. They used to have sexual intercourse with males instead o

حَدَّثَنَا أَحْمَدُ بْنُ مَنِيعٍ، حَدَّثَنَا إِسْمَاعِيلُ بْنُ إِبْرَاهِيمَ، حَدَّثَنَا عَلِيُّ بْنُ زَيْدٍ، عَنْ سَعِيدِ بْنِ الْمُسَيَّبِ، عَنْ عَلِيِّ بْنِ أَبِي طَالِبٍ، قَالَ قَالَ رَسُولُ اللَّهِ صلى الله عليه وسلم ‏ "‏ إِنَّ اللَّهَ حَرَّمَ مِنَ الرَّضَاعِ مَا حَرَّمَ مِنَ النَّسَبِ ‏"‏ ‏.‏ قَالَ وَفِي الْبَابِ عَنْ عَائِشَةَ وَابْنِ عَبَّاسٍ وَأُمِّ حَبِيبَةَ ‏.‏ قَالَ أَبُو عِيسَى حَدِيثُ عَلِيٍّ حَسَنٌ صَحِيحٌ ‏.‏

Ali (bin Abi Talib) narrated that The Messenger of Allah said:“Indeed Allah has made unlawful through suckling whatever He made unlawful through lineage.”

حَدَّثَنَا بُنْدَارٌ، حَدَّثَنَا يَحْيَى بْنُ سَعِيدٍ الْقَطَّانُ، حَدَّثَنَا مَالِكٌ، ح وَحَدَّثَنَا إِسْحَاقُ بْنُ مُوسَى الأَنْصَارِيُّ، قَالَ حَدَّثَنَا مَعْنٌ، قَالَ حَدَّثَنَا مَالِكٌ، عَنْ عَبْدِ اللَّهِ بْنِ دِينَارٍ، عَنْ سُلَيْمَانَ بْنِ يَسَارٍ، عَنْ عُرْوَةَ بْنِ الزُّبَيْرِ، عَنْ عَائِشَةَ، قَالَتْ قَالَ رَسُولُ اللَّهِ صلى الله عليه وسلم ‏ "‏ إِنَّ اللَّهَ حَرَّمَ مِنَ الرَّضَاعَةِ مَا حَرَّمَ مِنَ الْوِلاَدَةِ ‏"‏ ‏.‏ قَالَ أَبُو عِيسَى هَذَا حَدِيثٌ حَسَنٌ صَحِيحٌ ‏.‏ وَالْعَمَلُ عَلَى هَذَا عِنْدَ أَهْلِ الْعِلْمِ مِنْ أَصْحَابِ النَّبِيِّ صلى الله عليه وسلم وَغَيْرِهِمْ لاَ نَعْلَمُ بَيْنَهُمْ فِي ذَلِكَ اخْتِلاَفًا ‏.‏

Aishah narrated that the Messenger of Allah said:“Indeed Allah has made unlawful through suckling whatever He made unlawful through birth.”

حَدَّثَنَا عَبْدُ اللَّهِ بْنُ يُوسُفَ، قَالَ حَدَّثَنَا مَالِكٌ، عَنْ هِشَامِ بْنِ عُرْوَةَ، عَنْ أَبِيهِ، عَنْ عَائِشَةَ، قَالَتْ كُنْتُ أُرَجِّلُ رَأْسَ رَسُولِ اللَّهِ صلى الله عليه وسلم وَأَنَا حَائِضٌ‏.‏

Narrated `Aisha:While in menses, I used to comb the hair of Allah's Messenger (ﷺ)

حَدَّثَنَا إِبْرَاهِيمُ بْنُ مُوسَى، قَالَ أَخْبَرَنَا هِشَامُ بْنُ يُوسُفَ، أَنَّ ابْنَ جُرَيْجٍ، أَخْبَرَهُمْ قَالَ أَخْبَرَنِي هِشَامٌ، عَنْ عُرْوَةَ، أَنَّهُ سُئِلَ أَتَخْدُمُنِي الْحَائِضُ أَوْ تَدْنُو مِنِّي الْمَرْأَةُ وَهْىَ جُنُبٌ فَقَالَ عُرْوَةُ كُلُّ ذَلِكَ عَلَىَّ هَيِّنٌ، وَكُلُّ ذَلِكَ تَخْدُمُنِي، وَلَيْسَ عَلَى أَحَدٍ فِي ذَلِكَ بَأْسٌ، أَخْبَرَتْنِي عَائِشَةُ أَنَّهَا كَانَتْ تُرَجِّلُ ـ تَعْنِي ـ رَأْسَ رَسُولِ اللَّهِ صلى الله عليه وسلم وَهِيَ حَائِضٌ، وَرَسُولُ اللَّهِ صلى الله عليه وسلم حِينَئِذٍ مُجَاوِرٌ فِي الْمَسْجِدِ، يُدْنِي لَهَا رَأْسَهُ وَهْىَ فِي حُجْرَتِهَا، فَتُرَجِّلُهُ وَهْىَ حَائِضٌ‏.‏

Narrated `Urwa:A person asked me, "Can a woman in menses serve me? And can a Junub woman come close to me?" I replied, "All this is easy for me. All of them can serve me, and there is no harm for any other person to do the same. `Aisha told me that she used to comb the hair of Allah's Messenger (ﷺ) while she was in her menses, and he was in I`tikaf (in the mosque). He would bring his head near her in her room and she would comb his hair, while she used to be in her menses

أَخْبَرَنَا إِسْحَاقُ بْنُ إِبْرَاهِيمَ، قَالَ أَنْبَأَنَا سُفْيَانُ، عَنْ عَبْدِ الرَّحْمَنِ بْنِ الْقَاسِمِ بْنِ مُحَمَّدِ بْنِ أَبِي بَكْرٍ الصِّدِّيقِ، - رضى الله عنه - عَنْ أَبِيهِ، عَنْ عَائِشَةَ، قَالَتْ خَرَجْنَا مَعَ رَسُولِ اللَّهِ صلى الله عليه وسلم لاَ نُرَى إِلاَّ الْحَجَّ فَلَمَّا كُنَّا بِسَرِفَ حِضْتُ فَدَخَلَ عَلَىَّ رَسُولُ اللَّهِ صلى الله عليه وسلم وَأَنَا أَبْكِي فَقَالَ ‏"‏ مَا لَكِ أَنَفِسْتِ ‏"‏ ‏.‏ قُلْتُ نَعَمْ ‏.‏ قَالَ ‏"‏ هَذَا أَمْرٌ كَتَبَهُ اللَّهُ عَزَّ وَجَلَّ عَلَى بَنَاتِ آدَمَ فَاقْضِي مَا يَقْضِي الْحَاجُّ غَيْرَ أَنْ لاَ تَطُوفِي بِالْبَيْتِ ‏"‏ ‏.‏

It was narrated that 'Aishah said:"We went out with the Messenger of Allah (ﷺ) with no intention other than Hajj. When he was in Sarif I began menstruating. The Messenger of Allah (ﷺ) entered upon me and I was weeping. He said: 'What is the matter with you? Has you Nifas begun?' I said: 'Yes.' He said: 'This is something that Allah the Mighty and Sublime has decreed for the daughters of Adam. Do what the pilgrims do but do not perform Tawaf around the House

أَخْبَرَنَا عِمْرَانُ بْنُ يَزِيدَ، قَالَ حَدَّثَنَا إِسْمَاعِيلُ بْنُ عَبْدِ اللَّهِ، - وَهُوَ ابْنُ سَمَاعَةَ - قَالَ حَدَّثَنَا الأَوْزَاعِيُّ، قَالَ حَدَّثَنَا يَحْيَى بْنُ سَعِيدٍ، قَالَ أَخْبَرَنِي هِشَامُ بْنُ عُرْوَةَ، عَنْ عُرْوَةَ، أَنَّ فَاطِمَةَ بِنْتَ قَيْسٍ، مِنْ بَنِي أَسَدِ قُرَيْشٍ أَنَّهَا أَتَتْ رَسُولَ اللَّهِ صلى الله عليه وسلم فَذَكَرَتْ أَنَّهَا تُسْتَحَاضُ فَزَعَمَتْ أَنَّهُ قَالَ لَهَا ‏ "‏ إِنَّمَا ذَلِكِ عِرْقٌ فَإِذَا أَقْبَلَتِ الْحَيْضَةُ فَدَعِي الصَّلاَةَ وَإِذَا أَدْبَرَتْ فَاغْتَسِلِي وَاغْسِلِي عَنْكِ الدَّمَ ثُمَّ صَلِّي ‏"‏ ‏.‏

It was narrated from Fatimah bint Qais from Banu Asad Quraish that she came to the Prophet (ﷺ) and mentioned that she suffered from Istihadah. She said that he said to her:"That is a vein, so when the time of menstruation comes, stop praying, and when it goes, take your bath and wash the blood from yourself then pray

ونضرب لك مثالا، فنقول: إذا افتقر الإنسان إلى الصبر عن شهوة الجماع، وقد غلبت عليه بحيث لا يملك فرجه ولا عينه ولا قلبه، فعلاج ذلك بثلاثة أشياء:

وقصر بقوم في خلطة الناس حتى اعتزلوهم في الطاعات كالجمعة والجماعات والجهاد وتعلم العلم وتجاوز بقوم حتى خالطوهم في الظلم والمعاصي والآثام

وقال أيضا : من ترك قراءة القرآن ولزوم الجماعات وحضور الجنائز وعيادة المرضى وادعى بهذا الشأن فهو مدع

قال وربما شغله بوسواسه حتى تفوته الجماعة وربما فاته الوقت ويشغله بوسوسته في النية حتى تفوته التكبيرة الأولى وربما فوت عليه ركعة أو أكثر ومنهم من يحلف أنه لا يزيد على هذا ثم يكذب

وكذلك عزمه على تحريق المتخلفين عن الصلاة معه في الجماعة ولم يقل لو قضى لهم الصلاة لكانت

وأعمال الجوارح كالصلاة والجهاد ونقل الأقدام إلى الجمعة والجماعات ومساعدة العاجز والإحسان إلى الخلق ونحو ذلك

Gender differences in pornography use and sexual health outcomes: a systematic review and meta-analysis.: Background: Pornography consumption is increasingly prevalent worldwide, yet its gender-specific associations with sexual health outcomes remain poorly understood. Aim: This systematic review and meta-analysis aimed to evaluate gender differences in pornography use and its associations with sexual function, sexual satisfaction, masturbation frequency, and psychological parameters among adult men and women. Methods: Following PRISMA 2020 statement, systematic searches were conducted across PubMed

Couple-Based Psychosexual Support Following Prostate Cancer Surgery: Results of a Feasibility Pilot Randomized Control Trial.: Introduction: Surgery for prostate cancer can result in distressing side effects such as sexual difficulties, which are associated with lower levels of dyadic functioning. The study developed and tested an intervention to address sexual, relational, and emotional aspects of the relationship after prostate cancer by incorporating elements of family systems theory and sex therapy. Aims: To develop and test the feasibility and acceptability of relational psychosexual treatment for couples with pros

INFERTILITY AND SEXUAL DYSFUNCTIONS: A SYSTEMATIC LITERATURE REVIEW.: This study aimed to investigate whether infertility and its treatment affect couple sexuality. A systematic literature review was performed, focusing on female and male sexual dysfunctions due to infertility. The method was descriptive, using a meta-synthesis of scientific research published between 2012 and 2017 in the English language. The search for suitable studies was carried out with the research databases Medline, CINAHL, PubMed and ScienceDirect using the following keywords: infertility,

Sexual dysfunction related to psychiatric disorders: a systematic review.: Background: Sexual dysfunction is thought to be highly prevalent in patients with psychiatric disorders. Factors such as the use of psychotropic substances (ie, psychopharmaceuticals and drugs), age, or somatic diseases may contribute to sexual problems, but the extent to which psychopathology itself affects sexual functioning is not well understood. Aim: The study sought to provide an overview of the literature on the prevalence of sexual dysfunction in psychotropic-free and somatic disease-fre

Psychological and Interpersonal Dimensions of Sexual Function and Dysfunction.: Introduction: Psychological, interpersonal, and sociocultural factors play a significant role in making one vulnerable to developing a sexual concern, in triggering the onset of a sexual difficulty, and in maintaining sexual dysfunction in the long term. Aim: To focus on psychological and interpersonal aspects of sexual functioning in women and men after a critical review of the literature from 2010 to the present. Methods: This report is part 1 of 2 of our collaborative work during the 2015 Int

Meta-analysis of Results of Testosterone Therapy on Sexual Function Based on International Index of Erectile Function Scores.: Context: The interpretation of available clinical evidence related to the effect of testosterone (T) treatment (TTh) on sexual function has been inconsistent, in part due to the use of different and self-reported measures to assess outcomes. The International Index of Erectile Function (IIEF) is the most frequently used validated tool to assess male sexual function. Objective: To perform a meta-analysis of available data evaluating the effect of TTh on male sexual function using IIEF as the prim

Phenomenology and treatment of behavioural addictions.

Behavioural addictions are characterized by an inability to resist an urge or drive resulting in actions that are harmful to oneself or others. Behavioural addictions share characteristics with substance and alcohol abuse, and in areas such as natural history, phenomenology, and adverse consequences. Behavioural addictions include pathological gambling, kleptomania, pyromania, compulsive buying, compulsive sexual behaviour, Internet addiction, and binge eating disorder. Few studies have examined the efficacy of pharmacological and psychological treatment for the various behavioural addictions, and therefore, currently, no treatment recommendations can be made.

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Natural rewards, neuroplasticity, and non-drug addictions.

There is a high degree of overlap between brain regions involved in processing natural rewards and drugs of abuse. "Non-drug" or "behavioral" addictions have become increasingly documented in the clinic, and pathologies include compulsive activities such as shopping, eating, exercising, sexual behavior, and gambling. Like drug addiction, non-drug addictions manifest in symptoms including craving, impaired control over the behavior, tolerance, withdrawal, and high rates of relapse. These alterations in behavior suggest that plasticity may be occurring in brain regions associated with drug addiction. In this review, I summarize data demonstrating that exposure to non-drug rewards can alter neural plasticity in regions of the brain that are affected by drugs of abuse. Research suggests that there are several similarities between neuroplasticity induced by natural and drug rewards and that, …

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Urinary and sexual dysfunction after rectal cancer treatment.

In light of the improving prognosis for patients with rectal cancer, the quality of functional outcome has become increasingly important. Despite the good functional results achieved by expert surgeons, large multicenter studies show that urogenital dysfunction remains a common problem after rectal cancer treatment. More than half of patients experience a deterioration in sexual function, consisting of ejaculatory problems and impotence in men and vaginal dryness and dyspareunia in women. Urinary dysfunction occurs in one-third of patients treated for rectal cancer. Surgical nerve damage is the main cause of urinary dysfunction. Radiotherapy seems to have a role in the development of sexual dysfunction, without affecting urinary function. Pelvic autonomic nerves are especially at risk in cases of low rectal cancer and during abdominoperineal resection. Data concerning nerve damage during…

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Sexual function in chronic illness.

Introduction: Direct and indirect effects of chronic disease on sexual health are frequent and complex, but guidelines for their optimal management are lacking. With improved surgical and medical treatment of the underlying disease, the numbers of men and women needing assessment and management of associated sexual dysfunction are increasing. Aim: To provide recommendations/guidelines for the clinical management of sexual dysfunction within the context of chronic illness. Methods: An international consultation in collaboration with the major sexual medicine associations assembled 186 multidisciplinary experts from 33 countries into 25 committees. Nine experts from four countries compiled the recommendations of sexual dysfunction in chronic illness and cancer with four focusing on neurological, renal, and psychiatric disease and lower urinary tract symptoms (LUTS). Searches were conducted…

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Pubertal development and behavior: hormonal activation of social and motivational tendencies.

Adolescence is a time of dramatic changes including rapid physical growth, the onset of sexual maturation, the activation of new drives and motivations, and a wide array of social and affective changes and challenges. This review focuses on behavioral changes in this interval and is organized by the claim that a key set of these adolescent changes are part of a more general re-orientation of social behavior. More specifically we hypothesize that pubertal maturation is associated with the activation of social and motivational tendencies, which in turn influence behavior and emotion in adolescence depending upon interactions with social context. We focus on evidence for two examples of these motivational changes: (1) increases in sensation-seeking (motivational tendency to want to experience high-intensity, exciting experiences) and (2) stronger natural interest in--and pursuit of--contact…

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Adolescent romantic relationships.

In this article, we review theoretical and empirical advances in research on romantic relationships between age 10 and the early twenties. First, we describe key themes in this area of research. Next, we briefly characterize the most influential theoretical formulations and distinctive methodological issues. We then describe research findings regarding pertinent social and developmental processes. We summarize the extensive findings on relationships with parents and peers as a context for romantic relationships. Finally, we characterize the growing evidence that adolescent romantic relationships are significant for individual adjustment and development, and we note promising directions for further research.

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Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders.

Dopamine is an essential neurotransmitter for many brain functions, and its dysfunction has been implicated in both neurological and psychiatric disorders. Parkinson's disease is an archetypal disorder of dopamine dysfunction characterised by motor, cognitive, behavioural, and autonomic symptoms. While effective for motor symptoms, dopamine replacement therapy is associated not only with motor side-effects, such as levodopa-induced dyskinesia, but also behavioural side-effects such as impulse control disorders (eg, pathological gambling and shopping, binge eating, and hypersexuality), punding (ie, abnormal repetitive non-goal oriented behaviours), and compulsive medication use. We review clinical features, overlapping molecular mechanisms, and a specific cognitive mechanism of habit learning that might underlie these behaviours. We integrate these mechanisms with the emerging view of the…

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HIV infection risk factors among male-to-female transgender persons: a review of the literature.

Male-to-female (MTF) transgender women experience a host of psychosocial issues such as discrimination, stigmatization, and marginalization. These challenges often limit economic opportunities, affect mental health, and may place members of this population at an increased risk for HIV infection. This report presents a review of the literature that focuses on risk factors for HIV infection specific to the MTF population. Factors including needle sharing and substance abuse, high-risk sexual behaviors, commercial sex work, health care access, lack of knowledge regarding HIV transmission, violence, stigma and discrimination, and mental health issues have been identified in the literature as risk factors for the acquisition of HIV infection by members of this population. Implications for care provided to MTF transgender persons are presented, and suggestions for future research are identifie…

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Toward a new 'EPOCH': optimising treatment outcomes with phosphodiesterase type 5 inhibitors for erectile dysfunction.

Despite the marked adverse impacts of erectile dysfunction (ED) on quality of life and well-being, many patients (and/or their partners) do not seek medical attention for this problem, do not receive treatment or discontinue such treatment even when it has effectively restored erectile responses to sexual stimulation. Phosphodiesterase type 5 (PDE5) inhibitors are considered first-line therapies for men with ED. To help physicians maximise the likelihood of treatment success with these agents, we conducted an English-language PubMed search of articles involving approved PDE5 inhibitors dating from 1 January 1998 (the year in which sildenafil citrate was introduced), through 31 August 2008. In addition to sildenafil, tadalafil and vardenafil, search terms included 'adhere*', 'couple*', 'effect*', 'effic*', 'partner*', 'satisf*', 'succe*' and 'treatment outcome.' Based on our analysis, phy…

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The advantage of social living: brain neuropeptides mediate the beneficial consequences of sex and motherhood.

Living in social groups is clearly beneficial for many species, often resulting in increased survival, enhanced fitness of the group, and progression of brain development and cognitive abilities. The development of the social brain has been promoted on the basis (i) of activation of reward centres by social stimuli, (ii) of positive consequences of close social interactions on emotionality (which is reinforcing by itself) and on general fitness, and (iii) of negative health consequences in the absence or as a result of sudden interruption of social interactions. For example, social interactions as seen between mother and child or between mating partners have beneficial effects on the mental and physical health state, in particular on adaptive processes related to emotional and physiological stress coping in both sexes. Here, the neurobiological basis of social behaviour, in particular th…

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Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment.

Several studies, including work from the Parkinson's disease (PD) non-motor group and others, have established that the non-motor symptoms of PD are common, occur across all stages of PD, are under-reported, and are a key determinant of quality of life. Research suggests that the non-motor symptoms of the disease are frequently unrecognised by clinicians and remain untreated. Even when identified, there is a common perception that many of these symptoms are untreatable. The role of dopaminergic drugs in treating the various non-motor problems of PD, although clinically recognised, has received little attention. In this Review, we investigate the dopaminergic basis of the range of non-motor symptoms that occur in PD such as depression, apathy, sleep disorders (including rapid-eye movement sleep behaviour disorder), and erectile dysfunction. We discuss the evidence that these symptoms are …

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HPV infection in women: psychosexual impact of genital warts and intraepithelial lesions.

Introduction: Genital Human Papillomavirus (HPV) infection is the most commonly occurring sexually transmitted viral infection in humans. HPV is a wide family of DNA viruses, which may cause benign skin and mucosal tumors (genital, anal, or oral warts), intraepithelial neoplasias, and/or malignant cancers in different organs. Women are more susceptible to the oncogenic effect of HPVs, mostly at the genital site on the uterine cervix. Aims: This review analyzes the impact of: (i) genital warts (GWs) and their treatment; (ii) HPV-related genital, oral, and anal precancerous lesions on women's sexual function. Methods: A Medline search was carried out. Search terms were HPV, GWs, intraepithelial neoplasia, cervical cancer, anal cancer, oral cancer, epidemiology, HPV risk factors, sexual dysfunctions, desire disorders, arousal disorders, dyspareunia, vulvar vestibulitis, vulvodynia, orgasmic…

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Antipsychotic-induced hyperprolactinemia.

Use of antipsychotic agents has been associated with hyperprolactinemia, or elevated prolactin levels; this hormonal abnormality can interfere with the functioning of reproductive, endocrine, and metabolic systems. As antipsychotic agents are increasingly used for both United States Food and Drug Administration-approved and nonapproved indications, many individuals are at risk for developing antipsychotic-induced hyperprolactinemia. First-generation antipsychotics pose the greatest risk of causing this adverse effect; however, second-generation antipsychotics, particularly risperidone and paliperidone, also often increase prolactin secretion. Hyperprolactinemia has short- and long-term consequences that can seriously affect quality of life: menstrual disturbances, galactorrhea, sexual dysfunction, gynecomastia, infertility, decreased bone mineral density, and breast cancer. Although many…

matched on Sexual Dysfunction, Physiological (mesh)

Human responses to the geophysical daily, annual and lunar cycles.

Collectively the daily, seasonal, lunar and tidal geophysical cycles regulate much of the temporal biology of life on Earth. The increasing isolation of human societies from these geophysical cycles, as a result of improved living conditions, high-quality nutrition and 24/7 working practices, have led many to believe that human biology functions independently of them. Yet recent studies have highlighted the dominant role that our circadian clock plays in the organisation of 24 hour patterns of behaviour and physiology. Preferred wake and sleep times are to a large extent driven by an endogenous temporal program that uses sunlight as an entraining cue. The alarm clock can drive human activity rhythms but has little direct effect on our endogenous 24 hour physiology. In many situations, our biology and our society appear to be in serious opposition, and the damaging consequences to our hea…

matched on Sexual Behavior (mesh)

Oxytocin and appetite.

Oxytocin has potent central effects on feeding behaviour, as well as on social and sexual behaviours, and one likely substrate for its anorectic effect is the ventromedial nucleus of the hypothalamus. This nucleus expresses a high density of oxytocin receptors, but contains very few oxytocin-containing fibres, hence it is a likely target of 'neurohormonal' actions of oxytocin, including possibly oxytocin released from the dendrites of magnocellular oxytocin neurones. As oxytocin release from dendrites is regulated independent of electrical activity and of secretion from the neurohypophysis, exactly how this release is regulated by metabolic and reproduction-related signals remains to be established fully. Intriguingly though, it looks as though this central release of oxytocin from magnocellular neurons might be instrumental in a fundamental shift in motivational behaviour - switching be…

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Central vasopressin and oxytocin release: regulation of complex social behaviours.

The neuropeptides arginine vasopressin (AVP) and oxytocin (OXT) are acknowledged as important modulators of diverse social behaviours. Here we discuss recent studies using intracerebral microdialysis to investigate the dynamics of AVP and OXT release patterns within distinct brain regions during the display of social behaviours in rats. Manipulation of local receptor-mediated actions of AVP and OXT via retrodialysis of either agonists or antagonists revealed the behavioural significance of changes in local neuropeptide release. Alterations in local AVP and OXT within, e.g. the medio-lateral septum, the central amygdala or the hypothalamic paraventricular nucleus (PVN) were associated with intermale and maternal aggression, respectively. Moreover, increased OXT release within the PVN was associated with male sexual behaviour and successful mating. Using retrodialysis, we found that AVP re…

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Differentiating antidepressants of the future: efficacy and safety.

There have been significant advances in the treatment of depression since the serendipitous discovery that modulating monoaminergic neurotransmission may be a pathological underpinning of the disease. Despite these advances, particularly over the last 15years with the introduction of selective serotonin and/or norepinephrine reuptake inhibitors (SNRI), there still remain multiple unmet clinical needs that would represent substantial improvements to current treatment regimens. In terms of efficacy there have been improvements in the percentage of patients achieving remission but this can still be dramatically improved and, in fact, issues still remain with relapse. Furthermore, advances are still required in terms of improving the onset of efficacy as well as addressing the large proportion of patients who remain treatment resistant. While this is not well understood, collective research …

matched on Sexual Dysfunction, Physiological (mesh)

Youth in sub-Saharan Africa.

Sub-Saharan Africa is going through rapid social, political, and economic transformations that have a profound impact on youth. The present review explores trends and outcomes as they relate to education, family formation and sexual and reproductive health and the interrelationships among these areas. It is based on both published and unpublished reports. Over the past 20 years, school enrollment has increased for much of the subcontinent; although the gender gap has narrowed, females remain educationally disadvantaged. Likewise, marriage is occurring later today than a generation ago, posing new challenges of out-of-wedlock births, clandestine abortions, and an increased likelihood of engaging in premarital sex. So, too, although there has been a slowing of the population growth in much of the region, in many countries of sub-Saharan Africa, the population is doubling every 30 years. Al…

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Late adverse effects of radiation therapy for rectal cancer - a systematic overview.

Purpose: The use of radiation therapy (RT) together with improvement in the surgical treatment of rectal cancer improves survival and reduces the risk for local recurrences. Despite these benefits, the adverse effects of radiation therapy limit its use. The aim of this review was to present a comprehensive overview of published studies on late adverse effects related to the RT for rectal cancer. Methods: Meta-analyses, reviews, randomised clinical trials, cohort studies and case-control studies on late adverse effects, due to pre- or postoperative radiation therapy and chemo-radiotherapy for rectal cancer, were systematically searched. Most information was obtained from the randomised trials, especially those comparing preoperative short-course 5 x 5 Gy radiation therapy with surgery alone. Results: The late adverse effects due to RT were bowel obstructions; bowel dysfunction presented a…

matched on Sexual Dysfunction, Physiological (mesh)

Sexual function in chronic kidney disease.

Endocrine abnormalities are common in patients with chronic kidney disease (CKD) and lead to sexual dysfunction, anemia, hyperparathyroidism, and altered mineral metabolism. Common clinical problems include disturbances in menstruation in women, erectile dysfunction in men, and decreased libido and infertility in both sexes. Organic factors tend to be prominent and are related to uremia and other comorbid illnesses. Psychological factors and depression may exacerbate the primary problem. Alterations in the hypothalamic-pituitary axis are seen early in CKD and tend to worsen after patients start dialysis. Hypogonadism plays a dominant role in male sexual function, whereas changes in hypothalamic-pituitary function predominate in female sexual dysfunction. In patients on dialysis, treatment strategies include optimizing dose of dialysis, correction of anemia with erythropoietin, and correc…

matched on Sexual Dysfunction, Physiological (mesh)

Romantic love: a mammalian brain system for mate choice.

Mammals and birds regularly express mate preferences and make mate choices. Data on mate choice among mammals suggest that this behavioural 'attraction system' is associated with dopaminergic reward pathways in the brain. It has been proposed that intense romantic love, a human cross-cultural universal, is a developed form of this attraction system. To begin to determine the neural mechanisms associated with romantic attraction in humans, we used functional magnetic resonance imaging (fMRI) to study 17 people who were intensely 'in love'. Activation specific to the beloved occurred in the brainstem right ventral tegmental area and right postero-dorsal body of the caudate nucleus. These and other results suggest that dopaminergic reward and motivation pathways contribute to aspects of romantic love. We also used fMRI to study 15 men and women who had just been rejected in love. Preliminar…

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Serotonin and premature ejaculation: from physiology to patient management.

Introduction: Premature ejaculation (PE), whose pathophysiology is still not clearly identified, is the most common male sexual dysfunction, yet it remains underdiagnosed and undertreated. The aims of this paper are to provide a scientific and pharmacologic rationale, and to discuss to what extent selective serotonin reuptake inhibitors (SSRIs) can help patients with PE. Materials and methods: A comprehensive evaluation of available published data included analysis of published full-length papers that were identified with Medline and Cancerlit from January 1981 to January 2006. Official proceedings of internationally known scientific societies held in the same time period were also assessed. Results: The central ejaculatory neural circuit comprises spinal and cerebral areas that form a highly interconnected network. The sympathetic, parasympathetic, and somatic spinal centers, under the …

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A new look at the 5alpha-reductase inhibitor finasteride.

Finasteride is the first 5alpha-reductase inhibitor that received clinical approval for the treatment of human benign prostatic hyperplasia (BPH) and androgenetic alopecia (male pattern hair loss). These clinical applications are based on the ability of finasteride to inhibit the Type II isoform of the 5alpha-reductase enzyme, which is the predominant form in human prostate and hair follicles, and the concomitant reduction of testosterone to dihydrotestosterone (DHT). In addition to catalyzing the rate-limiting step in the reduction of testosterone, both isoforms of the 5alpha-reductase enzyme are responsible for the reduction of progesterone and deoxycorticosterone to dihydroprogesterone (DHP) and dihydrodeoxycorticosterone (DHDOC), respectively. Recent preclinical data indicate that the subsequent 3alpha-reduction of DHT, DHP and DHDOC produces steroid metabolites with rapid non-genomi…

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Sexual dysfunction and lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH).

Sexuality is an essential aspect of a couple's relationship and has a significant impact on life satisfaction. Benign prostatic hyperplasia (BPH) is a condition that commonly affects older men and is often associated with lower urinary tract symptoms (LUTS) and sexual dysfunction. Men with moderate-to-severe LUTS are at increased risk for sexual dysfunction, including moderate-to-severe erectile dysfunction (ED), ejaculatory dysfunction (EjD), and hypoactive desire (HD). The results of several recent large-scale studies have shown a consistent and strong relationship between LUTS and both ED and EjD. It appears that the pathophysiological mechanisms of LUTS and the related prostatic enlargement of BPH as well as certain treatments for this condition may have an impact on both the erection and ejaculation components of the sexual response. Validated questionnaires that assess sexual funct…

matched on Sexual Dysfunction, Physiological (mesh)

Obesity, the metabolic syndrome, and sexual dysfunction.

Sexual problems in both sexes appear to be widespread in society, influenced by both health-related and psychosocial factors, and are associated with impaired quality of life. Epidemiological studies suggest that modifiable health behaviors, including physical activity and leanness, are associated with a reduced risk for erectile dysfunction (ED) among men. Data from other surveys also indicate a higher prevalence of impotence in obese men. Obesity may be a risk factor for sexual dysfunction in both sexes; the data for the metabolic syndrome are very preliminary and need to be confirmed in larger epidemiologic studies. The high prevalence of ED in patients with cardiovascular risk factors suggests that abnormalities of the vasodilator system of penile arteries play an important role in the pathophysiology of ED. We have shown that one-third of obese men with ED can regain their sexual ac…

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