Practices

Telling somebody one thing you are quietly embarrassed about will bring you closer than a month of pleasant conversation.

It does not have to be dramatic. The worry you have never said out loud, the mistake you still think about at night, the thing you are no good at.…

You cannot decide to feel closer to people. You can decide to eat with them, walk with them, sit near them and say one true thing, and the closeness tends to follow.

The chemistry gets talked about a great deal and it is the least useful part. What you can act on is the diary: a standing meal with someone, a hand…

Go long enough without company and almost anyone will do. That is worth knowing about yourself, and worth watching for in someone who lives alone.

Loneliness does not make you a poor judge of character on purpose. It just lowers the bar until whoever turns up seems fine. The steadier answer is…

Four ordinary things take the edge off a hot temper: being touched by someone you trust, eating with people, moving your body hard enough to breathe, and sitting still for a few minutes a day.

None of them are about anger directly, which is the point. Exercise lowers what you are already carrying before the argument starts. A shared meal…

If eating together helps, it is the together that is helping. Being full is not a route to feeling close, and treating it as one goes wrong quickly for some people.

Sit down with somebody once a week and eat whatever you were going to eat anyway. That is the whole practice. If you notice yourself reaching for…

If you are around people constantly and falling out with them constantly, a quiet weekend on your own may do more for your temper than any conversation will.

Company loses its flavour when there is never a break in it, and irritation fills the gap. A deliberate stretch alone, a day or a weekend, lets you…

Closeness arrives much faster in a small group that keeps meeting than in a wide circle you see now and then. If you want to feel less alone, pick the small thing that repeats.

Six people who show up every Tuesday and say something real will know each other within a couple of months. Sixty acquaintances will not. It does not…

You can say what an SSRI does in one sentence. It blocks the doorway that carries serotonin back out of the gap between two nerve cells, so more of it stays there for longer and is likelier to be picked up.

Worth being able to say plainly, because most people are carrying something vaguer and more frightening than that. It also sets a fair expectation.…

The blockade is partial. Serotonin is not trapped in there forever: enzymes still break it down and the transporters that are not blocked carry on working.

That matters for accuracy and it matters for reassurance, because people do picture something flooding and stuck. It also explains why serotonin…

Serotonin syndrome comes from stacking, and the second agent is usually something nobody thought to mention: a migraine tablet, a cough medicine, a herbal remedy for low mood.

Triptans, tramadol, dextromethorphan, linezolid and St John's wort all count, as do other antidepressants. Someone who mentions in passing that they…

When someone says they react badly to normal doses of almost everything, take it as information about their body rather than as a personality trait.

Bodies differ in how fast they break a medicine down. Give two people the same dose and one of them may be holding far more of it for far longer,…

Whether a medicine works can turn on something as ordinary as taking it with food or moving it to bedtime.

Vilazodone is the clear case. On an empty stomach a good deal less of it is absorbed, and the nausea it can cause is easier to sit with overnight…

If a medicine leaves you wired, restless or with a pulse that will not settle, report it rather than tolerating it quietly.

The antidepressants that act on noradrenaline as well as serotonin can raise blood pressure and put nerves on edge, and with some of them that grows…

The same medicine can be dangerous given one way and safe given another. Slow release is not a marketing word.

Bupropion was pulled from the market over seizures and came back once a slow release form existed, because what drove the risk was the sharp peak…

The chemistry story runs backwards from how it is usually told. Nobody found a low chemical and then built a drug. They noticed what certain drugs did to mood and reasoned back to what must have been missing.

Reserpine emptied out the monoamines and people became depressed. Iproniazid and imipramine raised them and mood lifted. Out of that came the account…

Depression is not one thing with one address. Fatigue, blank concentration, lost libido and the loss of pleasure do not all come from the same place, so it helps to name which one you most want moved.

This is why two people with the same diagnosis get offered different tablets. A flat, pleasureless presentation points one way, a fatigued and achey…

Ask why the tablets take weeks. That one question sorts the honest accounts of how they work from the tidy story about a chemical being low.

Four competing versions sit under the same umbrella: too little released, reuptake running too hard, too much broken down, or receptors that need an…

Nearly all of them do the one thing: keep a monoamine hanging about in the synapse for longer. So when you hear that some other tablet is stronger, be a little sceptical.

Head to head, the differences in how much they lift mood are modest. Where they really differ is in everything else they do to you, and in how well…

SSRIs became the default for four reasons, and being more effective is not among them. They are easier to tolerate, taken once a day, far safer in overdose, and cheap as generics.

Tricyclics match them for lifting mood and are dangerous in overdose because of what they do to the heart. MAOIs carry food and drug interactions…

The standing side-effect list is sexual difficulty, less appetite, an unsettled stomach, disturbed sleep and headache. Sexual side effects are common, and almost nobody raises them unprompted.

So ask directly, and ask about sleep while you are there. People do not usually announce these things. They quietly stop taking the tablet and say…