Practices

You are right that the first drink takes the edge off. That is exactly what makes it hard, and pretending otherwise would only be untrue.

The calm is real at a small amount and it turns on you as the amount climbs, which is why the argument at eleven at night bears no resemblance to the…

Charge the phone in another room overnight. Not face down, not on the far side of the bed: another room, so that reaching it means standing up.

Distance is what does the work here, which is why the halfway versions never hold. If you use it as an alarm, a cheap clock settles that for the…

Some foods are formulated to be hard to stop eating. That is a design brief rather than a flaw in you, and it goes some way to explaining why one particular snack is the one you think about at eleven at night.

Knowing this moves the fight somewhere you can win it. Willpower at the moment of craving is a poor bet, and a decision made in the shop is a much…

Own brand products from large retailers were among the worst performers in these tests. A big name on the packet is not a quality check, however much it feels like one.

Own label goods are usually made under contract on thin margins with no independent verification of what comes out the other end. So the reassurance…

Your gut is not just plumbing. It makes many of the same chemicals your brain runs on and it is in constant conversation with your nervous system, which is part of why a bad stretch of digestion and a low mood so often turn up together.

If your stomach has been unsettled for weeks and your mood has slid over the same weeks, you do not have to work out which one is the real problem.…

When you find yourself reaching for something sweet again, try asking what the reaching is doing for you instead of telling yourself off. Comfort, a small rebellion, a way to stay awake: the answer usually points somewhere useful.

Talk about being good or bad closes the conversation down. Curiosity keeps it open, and it tends to surface the actual job the food is doing, which…

You are allowed to try something because it seems sensible. What you should not do is tell yourself it is proven, because that is what stops you noticing when it does not work for you.

The idea that going without company makes you hungrier for it is a reasonable guess, and mostly still a guess. Keep it in that shape. If a quieter…

A drink does loosen people up, and that is not a reason to use it. Something can work and still be a poor way to get what you want.

This one matters because the reasoning holds right up until the moment it does not. If a thing softens you tonight and charges you tomorrow, it is…

Say it plainly when you do not know. This seems to help and I am not sure why costs you far less than confidence you cannot back up.

People trust someone who marks their own guesses. It keeps you honest with yourself too, because a claim you have labelled a hunch is one you can…

You can say what an SSRI does in one sentence. It blocks the doorway that carries serotonin back out of the gap between two nerve cells, so more of it stays there for longer and is likelier to be picked up.

Worth being able to say plainly, because most people are carrying something vaguer and more frightening than that. It also sets a fair expectation.…

The blockade is partial. Serotonin is not trapped in there forever: enzymes still break it down and the transporters that are not blocked carry on working.

That matters for accuracy and it matters for reassurance, because people do picture something flooding and stuck. It also explains why serotonin…

Serotonin syndrome comes from stacking, and the second agent is usually something nobody thought to mention: a migraine tablet, a cough medicine, a herbal remedy for low mood.

Triptans, tramadol, dextromethorphan, linezolid and St John's wort all count, as do other antidepressants. Someone who mentions in passing that they…

When someone says they react badly to normal doses of almost everything, take it as information about their body rather than as a personality trait.

Bodies differ in how fast they break a medicine down. Give two people the same dose and one of them may be holding far more of it for far longer,…

Whether a medicine works can turn on something as ordinary as taking it with food or moving it to bedtime.

Vilazodone is the clear case. On an empty stomach a good deal less of it is absorbed, and the nausea it can cause is easier to sit with overnight…

If a medicine leaves you wired, restless or with a pulse that will not settle, report it rather than tolerating it quietly.

The antidepressants that act on noradrenaline as well as serotonin can raise blood pressure and put nerves on edge, and with some of them that grows…

The same medicine can be dangerous given one way and safe given another. Slow release is not a marketing word.

Bupropion was pulled from the market over seizures and came back once a slow release form existed, because what drove the risk was the sharp peak…

More of the medicine is not automatically better. What you are looking for is a level that sits inside the working range, and going past it usually brings side effects rather than sharper thinking.

It is a natural thought that if some helps a little, double would help twice as much. In practice people describe the higher dose as flat, or wired,…

Do not compare your dose with anybody else's. Two milligrams of one medicine and a hundred milligrams of another can both be perfectly ordinary, because strength per milligram differs from molecule to molecule.

This comes up in waiting rooms and family group chats and it causes real alarm about being on a lot. The number on the box only means something…

If a young driver in your house takes medication, the dose and the car keys belong together. Driving is the everyday task where one lost second costs the most.

The gap tends to open at weekends and in the holidays, when the dose gets skipped because there is no school and then someone drives anyway. Make it…

If you open atomoxetine capsules to mix the contents into food, keep it away from your eyes and wash your hands afterwards. The powder stings badly.

The molecule is acidic and cannot be softened without falling apart, so the fix is in the handling rather than the chemistry. Take it with something…